2013年6月
Genetic visualization of notch signaling in mammalian neurogenesis
CELLULAR AND MOLECULAR LIFE SCIENCES
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- 巻
- 70
- 号
- 12
- 開始ページ
- 2045
- 終了ページ
- 2057
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s00018-012-1151-x
- 出版者・発行元
- SPRINGER BASEL AG
Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.
- リンク情報
- ID情報
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- DOI : 10.1007/s00018-012-1151-x
- ISSN : 1420-682X
- PubMed ID : 22971775
- Web of Science ID : WOS:000319417800002