論文

筆頭著者 国際誌
2021年2月1日

Molecular mechanisms and physiological functions of mitophagy.

The EMBO journal
  • Mashun Onishi
  • ,
  • Koji Yamano
  • ,
  • Miyuki Sato
  • ,
  • Noriyuki Matsuda
  • ,
  • Koji Okamoto

40
3
開始ページ
e104705
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.15252/embj.2020104705

Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control. Mitophagy is promoted via specific mitochondrial outer membrane receptors, or ubiquitin molecules conjugated to proteins on the mitochondrial surface leading to the formation of autophagosomes surrounding mitochondria. Mitophagy-mediated elimination of mitochondria plays an important role in many processes including early embryonic development, cell differentiation, inflammation, and apoptosis. Recent advances in analyzing mitophagy in vivo also reveal high rates of steady-state mitochondrial turnover in diverse cell types, highlighting the intracellular housekeeping role of mitophagy. Defects in mitophagy are associated with various pathological conditions such as neurodegeneration, heart failure, cancer, and aging, further underscoring the biological relevance. Here, we review our current molecular understanding of mitophagy, and its physiological implications, and discuss how multiple mitophagy pathways coordinately modulate mitochondrial fitness and populations.

リンク情報
DOI
https://doi.org/10.15252/embj.2020104705
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33438778
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849173
ID情報
  • DOI : 10.15252/embj.2020104705
  • PubMed ID : 33438778
  • PubMed Central 記事ID : PMC7849173

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