論文

査読有り 国際誌
2018年5月23日

Neuromolecular basis of faded perception associated with unreality experience.

Scientific reports
  • Keita Yokokawa
  • Takehito Ito
  • Keisuke Takahata
  • Harumasa Takano
  • Yasuyuki Kimura
  • Masanori Ichise
  • Yoko Ikoma
  • Ayako Isato
  • Ming-Rong Zhang
  • Kazunori Kawamura
  • Hiroshi Ito
  • Hidehiko Takahashi
  • Tetsuya Suhara
  • Makiko Yamada
  • 全て表示

8
1
開始ページ
8062
終了ページ
8062
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-018-26382-9

Perceptual changes in shape, size, or color are observed in patients with derealization symptoms; however, the underlying neural and molecular mechanisms are not well understood. The current study explored the relationship between neural activity associated with altered colorfulness perception assessed by fMRI and striatal dopamine D2 receptor availability measured by [11C]raclopride PET in healthy participants. Inside an fMRI scanner, participants performed the saturation adaptation task, where they rated how much vivid/faded visual objects looked like real/unreal ones using a visual analog scale. We found that participants experienced greater unreality when they perceived fadedness than vividness despite physically identical saturation. The combined fMRI and PET analyses revealed that the faded perception-related activities of the dorsolateral prefrontal and parietal cortex were positively correlated with striatal D2 receptor availability. This finding may help to understand the neuromolecular mechanisms of faded perception associated with feeling unreal in derealization symptoms.

リンク情報
DOI
https://doi.org/10.1038/s41598-018-26382-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29795167
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966381
ID情報
  • DOI : 10.1038/s41598-018-26382-9
  • PubMed ID : 29795167
  • PubMed Central 記事ID : PMC5966381

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