論文

査読有り
2016年4月

Effects of dietary phosphate on glucose and lipid metabolism

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
  • Maerjianghan Abuduli
  • ,
  • Hirokazu Ohminami
  • ,
  • Tamaki Otani
  • ,
  • Hitoshi Kubo
  • ,
  • Haruka Ueda
  • ,
  • Yoshichika Kawai
  • ,
  • Masashi Masuda
  • ,
  • Hisami Yamanaka-Okumura
  • ,
  • Hiroshi Sakaue
  • ,
  • Hironori Yamamoto
  • ,
  • Eiji Takeda
  • ,
  • Yutaka Taketani

310
7
開始ページ
E526
終了ページ
E538
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1152/ajpendo.00234.2015
出版者・発行元
AMER PHYSIOLOGICAL SOC

Recent epidemiological and animal studies have suggested that excess intake of phosphate (P-i) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high P-i intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary P-i on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of P-i, i.e., 0.2 [low P-i (LP)], 0.6 [control P-i (CP)], and 1.2% [high P-i (HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V) over dot(CO2)/(V) over dot(O2)) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) expression were significantly increased in the brown adipose tissue (BAT) of the HP group. Our data demonstrated that a high-P-i diet can negatively regulate lipid synthesis in the liver and increase mRNA expression related to lipid oxidation and UCP1 in BAT, thereby preventing visceral fat accumulation. Thus, dietary P-i is a novel metabolic regulator.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1152/ajpendo.00234.2015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26786774
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000373272900006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1152/ajpendo.00234.2015
  • ISSN : 0193-1849
  • eISSN : 1522-1555
  • PubMed ID : 26786774
  • Web of Science ID : WOS:000373272900006

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