Takahiro Nagatake

J-GLOBAL         Last updated: Oct 24, 2019 at 20:34
 
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Name
Takahiro Nagatake
Affiliation
National Institutes of Biomedical Innovation,Health and Nutrition
Research funding number
80608737

Academic & Professional Experience

 
Apr 2018
 - 
Today
Senior Scientist, Center for Vaccine and Adjuvant Research, Laboratory of Vaccine Materials/Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition
 
Apr 2015
 - 
Mar 2018
Scientist, Laboratory of Vaccine Materials/Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition
 
Jan 2013
 - 
Mar 2015
Scientist, Laboratory of Vaccine Materials, National Institute of Biomedical Innovation
 
Apr 2012
 - 
Dec 2012
JSPS Research Fellowship for Young Scientists (PD)
 
Dec 2010
 - 
Dec 2012
Post doctoral fellow, Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University
 
Apr 2007
 - 
Mar 2010
JSPS Research Fellowship for Young Scientists (DC1)
 
Apr 2006
 - 
Mar 2010
Graduate student (Ph.D.), Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
 
Apr 2004
 - 
Mar 2006
Graduate student (MS), Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
 
Apr 2000
 - 
Mar 2004
Undergraduate student, School of Agriculture, Meiji University
 

Education

 
Apr 2006
 - 
Mar 2010
Department of Pathology, Immunology and Microbiology, Graduate School of Medicine, The University of Tokyo
 
Apr 2004
 - 
Mar 2006
Department of Medical Science, Graduate School of Medicine, The University of Tokyo
 
Apr 2000
 - 
Mar 2004
Department of Life Science, School of Agriculture, Meiji University
 
Apr 1996
 - 
Mar 1999
Narita High School
 

Awards & Honors

 
Dec 2017
Best Presentation Award, Japanese Society for Immunology
 
May 2007
Best Poster Award, The Institute of Medical Science, The University of Tokyo
 
Jun 2005
Young Investigator Award, Society for Mucosal Immunology
 
Mar 2004
Graduate first on the list, Meiji University
 
Apr 2002
Incentive Award, School of Agriculture, Meiji University
 

Published Papers

 
Takahashi I, Hosomi K, Nagatake T, Tobou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H
International Immunology      Oct 2019   [Refereed]
Li H, NeelankalJohn A, Nagatake T, Hamazaki Y, Jiang FX
FEBS open bio      Sep 2019   [Refereed]
Nagatake T, Hirata SI, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii KJ, Yokomizo T, Kunisawa J
Mucosal Immunology   12(5) 1082-1091   Sep 2019   [Refereed]
Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J
Allergy   74(8) 1522-1532   Aug 2019   [Refereed]
Nagatake T, Kunisawa J
International Immunology   31(9) 569-577   Aug 2019   [Refereed]
Saika A, Nagatake T, Kunisawa J
Frontiers in Nutrition   6 36   Apr 2019   [Refereed]
Hosomi K, Hinenoya A, Suzuki H, Nagatake T, Nishino T, Tojima Y, Hirata SI, Matsunaga A, Kondoh M, Yamasaki S, Kunisawa J
International Immunology   31(2) 91-100   Feb 2019   [Refereed]
Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
The Journal of Allergy and Clinical Immunology   142(2) 470-484.e12   Aug 2018   [Refereed]
Nagatake T, Suzuki H, Hirata SI, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J
International Immunology   30(10) 471-481   Jul 2018   [Refereed]
Sasaki A, Nagatake T, Egami R, Gu G, Takigawa I, Ikeda W, Nakatani T, Kunisawa J, Fujita Y
Cell Reports   23(4) 974-982   Apr 2018   [Refereed]
Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J
Scientific Reports   8(1) 2904   Feb 2018   [Refereed]
Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A, Otsuka A, Dainichi T, Nomura T, Ginhoux F, Ikuta K, Egawa G, Kabashima K
Scientific Reports   7(1) 14076   Oct 2017   [Refereed]
Hosomi K, Ohno H, Murakami H, Natsume-Kitatani Y, Tanisawa K, Hirata S, Suzuki H, Nagatake T, Nishino T, Mizuguchi K, Miyachi M, Kunisawa J
Scientific Reports   7(1) 4339   Jun 2017   [Refereed]
Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ
Immunity   45(6) 1299-1310   Dec 2016   [Refereed]
Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H
Cell Reports   13(1) 122-131   Oct 2015   [Refereed]
Sanosaka M, Fujimoto M, Ohkawara T, Nagatake T, Itoh Y, Kagawa M, Kumagai A, Fuchino H, Kunisawa J, Naka T, Takemori H
Immunology   145(2) 268-278   Jun 2015   [Refereed]
Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H
Scientific Reports   5 9750   Jun 2015   [Refereed]
Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H
PLoS ONE   10(5) e0127460   2015   [Refereed]
Nagatake T, Fujita H, Minato N, Hamazaki Y
PLoS ONE   9(6) e90638   2014   [Refereed]
Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH, Kiyono H
Allergy   67(4) 502-509   Apr 2012   [Refereed]
Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C
Cell Host & Microbe   9(5) 376-389   May 2011   [Refereed]
Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H
The Journal of Immunology   186(7) 4253-4262   Apr 2011   [Refereed]
Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H
The Journal of Experimental Medicine   206(11) 2351-2364   Oct 2009   [Refereed]
Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis.
Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H
The Journal of Immunology   179(9) 5897-5906   Nov 2007   [Refereed]
Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y
Vaccine   25(14) 2680-2687   Mar 2007   [Refereed]
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H
The Journal of Immunology   177(7) 4276-4280   Oct 2006   [Refereed]

Books etc

 
Dietary oil-originated lipid network and immune regulation
Takahiro Nagatake (Part:Joint Work)
Mar 2019   
Dietary quality and intestinal bacteria for the creation of gut environment in the control of health and diseases
Feb 2019   
Lymphoid tissues associated with gastrointestinal (GI) mucosa
Takahiro Nagatake (Part:Joint Work)
Springer Singapore   Feb 2019   
17,18-EpETEGPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques
Oct 2018   
Regulation of allergic diseases in the gut and skin by lipid metabolites
Mar 2018   
Immune regulation by nutrition and intestinal microbes for the control of vaccine efficacy and diseases
Feb 2018   
Unique function of mucosa-associated lymphoid tissues as targets of mucosal vaccines
Takahiro Nagatake and Jun Kunisawa (Part:Joint Work)
Current Topics in Pharmacology   Dec 2013   
Mucosa-associated lymphoid tissue and dynamics of lymphoid cells in the five different compartments in allergic diseases
Satoshi Fukuyama, Takahiro Nagatake and Hiroshi Kiyono (Part:Joint Work)
「Allergy Frontiers: Classification and Pathomechanisms」Editors: R. Pawankar, S.T. Holgate, L.J. Rosenwasser(Springer)   Apr 2009   

Conference Activities & Talks

 
BLT1 enhances gut IgA production against oral vaccine by inducing commensal bacteria-dependent proliferation of plasma cells
Nagatake T, Hirata S, Joga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii K, Yokomizo T, Kunisawa J.
The 19th International Congress of Mucosal Immunology (ICMI)   18 Jul 2019   
BLT1 promotes intestinal IgA production against oral vaccine by mediating commensal bacteria-dependent innate immune signals for plasma cell proliferation
Nagatake T, Hirata S, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii K, Yokomizo T, Kunisawa J
60th International Conference on the Bioscience of Lipids (ICBL)   19 Jun 2019   
Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice.
Nagatake T, Suzuki H, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii K, Yasutomi Y, Kunisawa J.
11 Dec 2018   
Organogenesis of inducible bronchus-associated lymphoid tissue plays an essential role in Ag85B-rhPIV2-based anti-tuberculosis respiratory vaccine in mice
Nagatake T, Suzuki H, Nasu A, Hirata S, Wada Y, Matsumoto N, Shimojou M, Morimoto S, Hosomi K, Ogami K, Tsujimura Y, Kawano M, Nosaka T, Yasutomi Y, Kunisawa J
23 Jan 2018   
17,18-EpETE, a metabolite of omega-3 essential fatty acids, inhibited neutron mobility and ameliorated skin inflammation in DNFB-induced contact hypersensitivity model
Nagatake T, Kikuta J, Honda T, Suzuki H, Arita M, Kiyono H, Ishii M, Kabashima K, Kunisawa J
13 Dec 2017   
オメガ3脂肪酸代謝物17,18-EpETEが発揮する抗アレルギー・抗炎症作用
長竹貴広、國澤純
19 Jul 2017   
17,18-epoxyeicosatetoraenoic acid impairs neutron mobility and ameliorates contact hypersensitivity
Nagatake T, Kunisawa J
The 1st Japan-Korea Joint Meeting on Mucosal Immunology   16 May 2017   
Organogenesis of inducible bronchus-associated lymphoid tissue has essential role in the induction of antigen-specific immune response by Ag85B-hPIV2-based anti-tuberculosis vaccine in mice
Nagatake T, Suzuki H, Nasu A, Hirata S, Wada Y, Matsumoto N, Shimojou M, Morimoto S, Hosomi K, Ogami K, Tsujimura Y, Kawano M, Nosaka T, Yasutomi Y, Kunisawa J
24 Jan 2017   
17,18-epoxy-eicosatetraenoic acid ameliorated contact hypersensitivity by inhibiting neutrophil infiltration into the skin
Nagatake T, Honda T, Suzuki H, Arita M. Kiyono H, Kabashima K, Kunisawa J
5 Dec 2016   
Contact hypersensitivity is ameliorated by 17,18-epoxy-eicosatetraenoic acid, a metabolite from eicosapentaenoic acid, in the skin
Nagatake T, Shiogama Y, Honda T, Isobe Y, Arita M, Matsumoto N, Shimojou M, Tiwari P, Suzuki H, Yasutomi Y, Kiyono H, Kabashima K, Kunisawa J
The 16th International Congress of Immunology   25 Aug 2016   
Inducible bronchus-associated lymphoid tissue plays an important role in the induction of antigen-specific immune response by Ag85B-hPIV2-based anti-tuberculosis vaccine in mice
Nagatake T, Wada Y, Matsumoto N, Shimojou M, Hirata S, Nasu A, Suzuki H, Hosomi K, Ogami K, Tsujimura Y, Kawano M, Nosaka T, Yasutomi Y, Kunisawa J
The 103rd Annual Meeting of The American Association of Immunologists   14 May 2016   
Essential role of inducible bronchus-associated lymphoid tissue genesis for the induction of antigen-specific immune response by Ag85B-hPIV2-based anti-tuberculosis vaccine in mice
Nagatake T, Wada Y, Matsumoto N, Shimojou M, Hirata S, Nasu A, Suzuki H, Hosomi K, Ogami K, Tsujimura Y, Kawano M, Nosaka T, Yasutomi Y, Kunisawa J
19 Jan 2016   
Prevention of gut and skin allergic inflammation by 17,18-epoxy-eicosatetraenoic acid, an endogenously generated lipid metabolite from linseed oil
Nagatake T, Arita M, Honda T, Suzuki H, Kiyono H, Kabashima K, Kunisawa J
20 Nov 2015   
Dietary ω3 fatty acid-originated 17,18-epoxyeicostetraenoic acid prevents the development of allergic inflammation in the gut and skin
Nagatake T, Arita M, Hayasaka T, Harada T, Iwamoto R, Honda T, Matsumoto N, Shimojou M, Nagasawa R, Shikata S, Hashimoto E, Kurashima Y, Suzuki Y, Suzuki H, Kabashima K, Arai H, Setou M, Kiyono H, Kunisawa J
The 6th International Conference on Phospholipase A2 and Lipid Mediators   10 Feb 2015   
Immunological and organogenesis diversity of mucosa-associated lymphoid tissues for the development of mucosal vaccine
Nagatake T, Matsumoto N, Shimojou M, Suzuki H, Fukuyama S, Sato S, Ogami K, Tsujimura Y, Kawano M, Nosaka T, Kiyono H, Yasutomi Y, Kunisawa J
20 Jan 2015   
Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine
Nagatake T, Fujita H, Minato N, Hamazaki Y
Jun 2014   
Eye immune responses initiated by uniquely developing tear duct-associated lymphoid tissue
Nagatake T, Sato S, Kunisawa J, Kiyono H
11 Dec 2013   
Claudin-5 is a crucial component of blood-thymus barrier by regulating vascular permeability
Nagatake T, Zhao Y-C, Hamazaki Y, Minato N
5 Dec 2012   
Claudin-5 plays a role in establishing specific thymic microenvironment by regulating vascular permeability
Nagatake T, Zhao Y-C, Minato N, Hamazaki Y
ThymUS 2012 International Conference   5 Nov 2012   
Mucosa-associated lymphoid tissue organogenesis
Nagatake T
Surface Barrier Immunology Study Group (SBARIS)   30 Jan 2010   
Tear duct-associated lymphoid tissue organogenesis in ocular immunity
Nagatake T
G-COE symposium on Mucosal Immunity   7 Dec 2009   
Role of Id2, RORgt and Cbfb2 for Differentiation of Mucosa-associated CD3-CD4+CD45+ Lymphoid Tissue Inducer Cells
Nagatake T, Fukuyama S, Tachibana M, Taniuchi I, Sato S, Okada K, Kim D-Y, Goda K, Kunisawa J, Kiyono H
2 Dec 2008   
Genesis of tear duct-associated lymphoid tissue is independent of Id2, RORgt but requires Cbfb2 transcriptional regulator
Nagatake T, Fukuyama S, Tachibana S, Taniuchi I, Kim D-Y, Takamura K, Sato S, Kunisawa J, Kiyono H
The 95th Annual Meeting of The American Association of Immunologists   Apr 2008   
Tear duct-associated lymphoid tissue organogenesis
Nagatake T, Fukuyama S, Kim D-Y, Takamura K, Sato S, Kunisawa J, Kiyono H
The 2nd Airways Mucosal Immunology Study-Group (AMIS) Program   Feb 2008   
Presence of Id2- and RORgt-independent lymphoid tissue organogenesis
Nagatake T, Fukuyama S, Kim D-Y, Takamura K, Kiyono H
The 14th East Asia Joint Symposium on Biomedical Research   Nov 2007   
Tissue-genesis of tear duct-associated lymphoid tissue is independent from the organogenesis-associated transcriptional gene regulation
Nagatake T, Fukuyama S, Kim D-Y, Takamura K, Kiyono H
The 13th International Congress of Mucosal Immunology   Jul 2007   
Presence of Id2- and RORgt-independent lymphoid tissue organogenesis
Nagatake T, Fukuyama S., Kim D-Y, Takamura K, Kiyono H
The 94th Annual meeting of The American Association of Immunologists   May 2007   
Distinct subsets of lymphoid tissue inducer cells: RORt independent CD3-CD4lowCD45+ cells are responsible for the NALT-genesis
Nagatake T, Fukuyama S, Kim D-Y, Takamura K, Kawamura A, Kiyono H
The 6th Awaji International Forum on Infection and Immunity   Sep 2006   
Unique Chemokine Receptores Expression between NALT and Peyer’s Patch Inducer Cells
Nagatake T, Fukuyama S, Kim D-Y, Takamura K, Kiyono H
Dec 2005   
Different Organogenesis Associated Gene Expression between NALT and Peyer’s Patch CD3-CD4+CD45+ Inducer Cells
Nagatake T, Fukuyama S, Kiyono H
The 12th International Congress of Mucosal Immunology   Jun 2005   

Research Grants & Projects

 
Japan Society for the Promotion of Science(JSPS): Grant-in-Aid for Young Scientists (B)
Project Year: Apr 2015 - Mar 2017    Investigator(s): Takahiro Nagatake
Japan Society for the Promotion of Science(JSPS): Grant-in-Aid for Research Activity Start-up
Project Year: Aug 2013 - Mar 2015    Investigator(s): Takahiro Nagatake
Japan Society for the Promotion of Science(JSPS): Grant-in-Aid for JSPS Research Fellow (PD)
Project Year: Apr 2012 - Mar 2013    Investigator(s): Takahiro Nagatake
Japan Society for the Promotion of Science(JSPS): Grant-in-Aid for JSPS Research Fellow (DC1)
Project Year: Apr 2007 - Mar 2010    Investigator(s): Takahiro Nagatake

Social Contribution

 
NHK
[Media coverage cooperation, Advisor, Informant]