論文

査読有り 国際誌
2020年8月

Electrical cortical stimulations modulate spike and post-spike slow-related high-frequency activities in human epileptic foci.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
  • Mitsuyoshi Nakatani
  • ,
  • Riki Matsumoto
  • ,
  • Katsuya Kobayashi
  • ,
  • Takefumi Hitomi
  • ,
  • Morito Inouchi
  • ,
  • Masao Matsuhashi
  • ,
  • Masako Kinoshita
  • ,
  • Takayuki Kikuchi
  • ,
  • Kazumichi Yoshida
  • ,
  • Takeharu Kunieda
  • ,
  • Susumu Miyamoto
  • ,
  • Ryosuke Takahashi
  • ,
  • Nobutaka Hattori
  • ,
  • Akio Ikeda

131
8
開始ページ
1741
終了ページ
1754
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clinph.2020.03.042

OBJECTIVE: Using interictal epileptiform discharges (IEDs), consisting of spikes and post-spike slow waves (PSSs), and IED-related high-frequency activities (HFAs), we elucidated inhibitory effects of electrical cortical stimulation (ECS) on human epileptic foci. METHODS: We recruited 8 patients with intractable focal epilepsy, and 50-Hz ECS was applied to the seizure-onset zone (SOZ) and non-SOZ. Before (5-min) and after (20-min) ECS, we evaluated the number of IED, the amplitudes of spikes and PSSs, spike-related HFA power, and PSS-related low gamma (30-50 Hz) activities. RESULTS: SOZ stimulation significantly decreased the number of IEDs and amplitude of spikes. Spike-related HFA power values in fast ripple (200-300 Hz) and ripple (80-150 Hz) bands were significantly suppressed only by SOZ stimulation in 4 and 3 patients, respectively. Among 4 patients with discrete PSSs, the amplitude ratio of spike/PSS decreased and the PSS-related low gamma activity power increased significantly in 2 patients and marginally in 1 patient. CONCLUSIONS: ECS potentially modulates cortical excitability by reducing excitation and increasing inhibition, and monitoring IED-related HFAs may help achieve the optimal effects of ECS. SIGNIFICANCE: IED and IED-related HFAs are dynamic, potential surrogate markers for epileptic excitability during the interictal period.

リンク情報
DOI
https://doi.org/10.1016/j.clinph.2020.03.042
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32504935
ID情報
  • DOI : 10.1016/j.clinph.2020.03.042
  • PubMed ID : 32504935

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