論文

査読有り 国際誌
2020年5月29日

Engagement of cortico-cortical and cortico-subcortical networks in a patient with epileptic spasms: An integrated neurophysiological study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
  • Takeshi Inoue
  • ,
  • Katsuya Kobayashi
  • ,
  • Riki Matsumoto
  • ,
  • Morito Inouchi
  • ,
  • Masaya Togo
  • ,
  • Jumpei Togawa
  • ,
  • Kiyohide Usami
  • ,
  • Akihiro Shimotake
  • ,
  • Masao Matsuhashi
  • ,
  • Takayuki Kikuchi
  • ,
  • Kazumichi Yoshida
  • ,
  • Hisashi Kawawaki
  • ,
  • Nobukatsu Sawamoto
  • ,
  • Takeharu Kunieda
  • ,
  • Susumu Miyamoto
  • ,
  • Ryosuke Takahashi
  • ,
  • Akio Ikeda

131
9
開始ページ
2255
終了ページ
2264
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clinph.2020.04.167

OBJECTIVE: We aimed to delineate the engagement of cortico-cortical and cortico-subcortical networks in the generation of epileptic spasms (ES) using integrated neurophysiological techniques. METHODS: Seventeen-year-old male patient with intractable ES underwent chronic subdural electrode implantation for presurgical evaluation. Networks were evaluated in ictal periods using high-frequency oscillation (HFO) analysis and in interictal periods using magnetoencephalography (MEG) and simultaneous electroencephalography, and functional magnetic resonance imaging (EEG-fMRI). Cortico-cortical evoked potentials (CCEPs) were recorded to trace connections among the networks. RESULTS: Ictal HFO revealed a network comprising multilobar cortical regions (frontal, parietal, and temporal), but sparing the positive motor area. Interictally, MEG and EEG-fMRI revealed spike-and-wave-related activation in these cortical regions. Analysis of CCEPs provided evidence of connectivity within the cortico-cortical network. Additionally, EEG-fMRI results indicate the involvement of subcortical structures, such as bilateral thalamus (predominantly right) and midbrain. CONCLUSIONS: In this case study, integrated neurophysiological techniques provided converging evidence for the involvement of a cortico-cortical network (sparing the positive motor area) and a cortico-subcortical network in the generation of ES in the patient. SIGNIFICANCE: Cortico-cortical and cortico-subcortical pathways, with the exception of the direct descending corticospinal pathway from the positive motor area, may play important roles in the generation of ES.

リンク情報
DOI
https://doi.org/10.1016/j.clinph.2020.04.167
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32736326
ID情報
  • DOI : 10.1016/j.clinph.2020.04.167
  • PubMed ID : 32736326

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