論文

査読有り 国際誌
2021年1月18日

An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS.

International journal of environmental research and public health
  • Andrew Kataba
  • Shouta M M Nakayama
  • Hokuto Nakata
  • Haruya Toyomaki
  • Yared B Yohannes
  • John Yabe
  • Kaampwe Muzandu
  • Golden Zyambo
  • Ayano Kubota
  • Takehisa Matsukawa
  • Kazuhito Yokoyama
  • Yoshinori Ikenaka
  • Mayumi Ishizuka
  • 全て表示

18
2
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijerph18020767

Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats (Rattus rattus) sampled from residential sites within varying distances from an abandoned lead-zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb-Zn mine. Furthermore, the Pb-T was strongly correlated (r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat's environmental habitat, thus a possible indicator of Pb exposure.

リンク情報
DOI
https://doi.org/10.3390/ijerph18020767
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33477475
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830958
ID情報
  • DOI : 10.3390/ijerph18020767
  • PubMed ID : 33477475
  • PubMed Central 記事ID : PMC7830958

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