Akila Mayeda

J-GLOBAL         Last updated: Oct 8, 2019 at 17:30
 
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Name
Akila Mayeda
Nickname
Akila
URL
http://www.fujita-hu.ac.jp/~gem-1/index-e.html
Affiliation
Fujita Health University
Section
Institute for Comprehensive Medical Science
Job title
Professor
Degree
Ph.D. (Doctor of Medical Science)
Research funding number
50212204

Profile

Believe or not, mRNAs encode all the designs of our bodies and all the plans of our living activity! However, nascent pre-mRNAs transcribed from human genes are terribly disrupted by intervening sequences, termed introns. The process to removed introns, termed pre-mRNA splicing, is therefore highly discriminatory and faithful. And thus, misregulation in this process causes disorders in cell functions, often with severe clinical consequences. We are studying to elucidate precise regulation system of splicing and challenges to understand the mechanism of aberrant splicing occurred in various serious diseases.

Research Areas

 
 

Published Papers

 
Fukumura K, Yoshimoto R, Hirose T, Inoue K, Mayeda A.
bioRxiv   784868   Sep 2019
Ueno T, Taga Y, Yoshimoto R, Mayeda A, Hattori S, Ogawa-Goto K
Proceedings of the National Academy of Sciences of the United States of America   116(19) 9340-9349   May 2019   [Refereed]
Chua HH, Kameyama T, Mayeda A, Yeh TH
International journal of molecular sciences   20(3) 773   Feb 2019   [Refereed]
Ohe K, Miyajima S, Abe I, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Ashida K, Kobayashi K, Enjoji M, Yanase T, Harada N, Utsumi T, Mayeda A
The Journal of steroid biochemistry and molecular biology   182 21-26   Sep 2018   [Refereed]
Abe A, Yamamoto Y, Katsumi A, Okamoto A, Tokuda M, Inaguma Y, Yamamoto K, Yanada M, Kanie T, Tomita A, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N
International journal of hematology   108(2) 208-212   Aug 2018   [Refereed]
Fukumura K, Inoue K, Mayeda A
Biochemical and biophysical research communications   496(3) 921-926   Feb 2018   [Refereed]
Ohe K, Miyajima S, Tanaka T, Hamaguchi Y, Harada Y, Horita Y, Beppu Y, Ito F, Yamasaki T, Terai H, Mori M, Murata Y, Tanabe M, Abe I, Ashida K, Kobayashi K, Enjoji M, Nomiyama T, Yanase T, Harada N, Utsumi T, Mayeda A
Frontiers in molecular biosciences   5 52   2018   [Refereed]
Yoshimoto R, Kaida D, Furuno M, Burroughs AM, Noma S, Suzuki H, Kawamura Y, Hayashizaki Y, Mayeda A, Yoshida M
RNA (New York, N.Y.)   23(1) 47-57   Jan 2017   [Refereed]
Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T
International journal of molecular sciences   17(10)    Oct 2016   [Refereed]
Fukumura K, Wakabayashi S, Kataoka N, Sakamoto H, Suzuki Y, Nakai K, Mayeda A, Inoue K
International journal of molecular sciences   17(8)    Aug 2016   [Refereed]
A. Abe, S. Mizuta, A. Okamoto, Y. Yamamoto, T. Kameyama, A. Mayeda, N. Emi
International journal of laboratory hematology   38(2) e15-e18   Apr 2016
Abe A, Yamamoto Y, Iba S, Kanie T, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Mizuta S, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N
Genes, chromosomes & cancer   55(3) 242-250   Mar 2016   [Refereed]
Abe A, Yamamoto Y, Iba S, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Kanie T, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Kameyama T, Mayeda A, Emi N
Cytogenetic and genome research   146(4) 279-284   2015   [Refereed]
Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S
Biochimica et biophysica acta      Oct 2015   [Refereed]
Shimada MK, Sasaki-Haraguchi N, Mayeda A
International journal of molecular sciences   16(5) 10376-10388   May 2015   [Refereed]
Rahman MA, Masuda A, Ohe K, Ito M, Hutchinson DO, Mayeda A, Engel AG, Ohno K
Scientific reports   3 2931   Oct 2013   [Refereed]
Suzuki H, Kameyama T, Ohe K, Tsukahara T, Mayeda A
FEBS letters   587(6) 555-561   Mar 2013   [Refereed]
Kameyama T, Suzuki H, Mayeda A
Nucleic acids research   40(16) 7896-7906   Sep 2012   [Refereed]
Sasaki-Haraguchi N, Shimada MK, Taniguchi I, Ohno M, Mayeda A
Biochemical and biophysical research communications   423(2) 289-294   Jun 2012   [Refereed]
Miyagawa R, Tano K, Mizuno R, Nakamura Y, Ijiri K, Rakwal R, Shibato J, Masuo Y, Mayeda A, Hirose T, Akimitsu N
RNA (New York, N.Y.)   18(4) 738-751   Apr 2012   [Refereed]
Ohe K, Mayeda A
Molecular and cellular biology   30(9) 2220-2228   May 2010   [Refereed]
Morikawa T, Manabe T, Ito Y, Yamada S, Yoshimi A, Nagai T, Ozaki N, Mayeda A
Neurochemistry international   56(6-7) 736-739   May 2010   [Refereed]
Manabe T, Ohe K, Katayama T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Imaizumi K, Reeves R, Tohyama M, Mayeda A
Genes to cells : devoted to molecular & cellular mechanisms   12(10) 1179-1191   Oct 2007   [Refereed]
Suzuki H, Zuo Y, Wang J, Zhang MQ, Malhotra A, Mayeda A
Nucleic acids research   34 e63   May 2006   [Refereed]
Tarapore P, Shinmura K, Suzuki H, Tokuyama Y, Kim SH, Mayeda A, Fukasawa K
FEBS letters   580(2) 399-409   Jan 2006   [Refereed]
Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A
Molecular and cellular biology   25(4) 1446-1457   Feb 2005   [Refereed]
Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A
Molecular and cellular biology   24(3) 1174-1187   Feb 2004   [Refereed]
Kondo S, Yamamoto N, Murakami T, Okumura M, Mayeda A, Imaizumi K
Genes to cells : devoted to molecular & cellular mechanisms   9(2) 121-130   Feb 2004   [Refereed]
Domsic JK, Wang Y, Mayeda A, Krainer AR, Stoltzfus CM
Molecular and cellular biology   23(23) 8762-8772   Dec 2003   [Refereed]
Manabe T, Katayama T, Sato N, Gomi F, Hitomi J, Yanagita T, Kudo T, Honda A, Mori Y, Matsuzaki S, Imaizumi K, Mayeda A, Tohyama M
Cell death and differentiation   10 698-708   Jun 2003   [Refereed]
Amada N, Tezuka T, Mayeda A, Araki K, Takei N, Todokoro K, Nawa H
Journal of biochemistry   133(5) 615-623   May 2003   [Refereed]
Hu D, Mayeda A, Trembley JH, Lahti JM, Kidd VJ
The Journal of biological chemistry   278(10) 8623-8629   Mar 2003   [Refereed]
Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG
The EMBO journal   21(22) 6195-6204   Nov 2002   [Refereed]
Cowper AE, Cáceres JF, Mayeda A, Screaton GR
The Journal of biological chemistry   276(52) 48908-48914   Dec 2001   [Refereed]
Bilodeau PS, Domsic JK, Mayeda A, Krainer AR, Stoltzfus CM
Journal of virology   75(18) 8487-8497   Sep 2001   [Refereed]
Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN
The Journal of biological chemistry   276(34) 32300-32312   Aug 2001   [Refereed]
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE
The Journal of cell biology   154(1) 25-32   Jul 2001   [Refereed]
Eperon IC, Makarova OV, Mayeda A, Munroe SH, Cáceres JF, Hayward DG, Krainer AR
Molecular and cellular biology   20(22) 8303-8318   Nov 2000   [Refereed]
Dirksen WP, Li X, Mayeda A, Krainer AR, Rottman FM
The Journal of biological chemistry   275(37) 29170-29177   Sep 2000   [Refereed]
Chew SL, Liu HX, Mayeda A, Krainer AR
Proceedings of the National Academy of Sciences of the United States of America   96(19) 10655-10660   Sep 1999   [Refereed]
Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR
The EMBO journal   18(16) 4560-4570   Aug 1999   [Refereed]
Ismaïli N, Pérez-Morga D, Walsh P, Mayeda A, Pays A, Tebabi P, Krainer AR, Pays E
Molecular and biochemical parasitology   102 103-115   Jul 1999   [Refereed]
Caputi M, Mayeda A, Krainer AR, Zahler AM
The EMBO journal   18(14) 4060-4067   Jul 1999   [Refereed]
Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M
The Journal of biological chemistry   274(16) 11125-11131   Apr 1999   [Refereed]
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements.
Mayeda A, Screaton GR, Chandler SD, Fu XD, Krainer AR
Molecular and cellular biology   19 1853-1863   Mar 1999   [Refereed]
Mayeda A, Krainer AR
Methods in molecular biology (Clifton, N.J.)   118 309-314   1999   [Refereed]
Mayeda A, Krainer AR
Methods in molecular biology (Clifton, N.J.)   118 315-321   1999   [Refereed]
Mayeda A, Munroe SH, Xu RM, Krainer AR
RNA (New York, N.Y.)   4(9) 1111-1123   Sep 1998   [Refereed]
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.
Hanamura A, Cáceres JF, Mayeda A, Franza BR Jr, Krainer AR
RNA (New York, N.Y.)   4 430-444   Apr 1998   [Refereed]
Jokan L, Dong AP, Mayeda A, Krainer AR, Xu RM
Acta crystallographica. Section D, Biological crystallography   53 615-618   Sep 1997   [Refereed]
RCC1 and nuclear organization.
Huang S, Mayeda A, Krainer AR, Spector DL
Molecular biology of the cell   8 1143-1157   Jun 1997   [Refereed]
Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD
Proceedings of the National Academy of Sciences of the United States of America   94(8) 3596-3601   Apr 1997   [Refereed]
Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.
Xu RM, Jokhan L, Cheng X, Mayeda A, Krainer AR
Structure (London, England : 1993)   5 559-570   Apr 1997   [Refereed]
Lopato S, Mayeda A, Krainer AR, Barta A
Proceedings of the National Academy of Sciences of the United States of America   93(7) 3074-3079   Apr 1996   [Refereed]
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.
Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR
The EMBO journal   14 4336-4349   Sep 1995   [Refereed]
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.
Mayeda A, Munroe SH, Cáceres JF, Krainer AR
The EMBO journal   13 5483-5495   Nov 1994   [Refereed]
O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL
The Journal of cell biology   124(3) 249-260   Feb 1994   [Refereed]
The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.
Huang M, Rech JE, Northington SJ, Flicker PF, Mayeda A, Krainer AR, LeStourgeon WM
Molecular and cellular biology   14 518-533   Jan 1994   [Refereed]
Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM
Genes & development   7(12B) 2598-2608   Dec 1993   [Refereed]
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF.
Eperon IC, Ireland DC, Smith RA, Mayeda A, Krainer AR
The EMBO journal   12 3607-3617   Sep 1993   [Refereed]
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.
Mayeda A, Helfman DM, Krainer AR
Molecular and cellular biology   13 2993-3001   May 1993   [Refereed]
Fu XD, Mayeda A, Maniatis T, Krainer AR
Proceedings of the National Academy of Sciences of the United States of America   89(23) 11224-11228   Dec 1992   [Refereed]
Mayeda A, Zahler AM, Krainer AR, Roth MB
Proceedings of the National Academy of Sciences of the United States of America   89(4) 1301-1304   Feb 1992   [Refereed]
Mayeda A, Krainer AR
Cell   68(2) 365-375   Jan 1992   [Refereed]
Krainer AR, Mayeda A, Kozak D, Binns G
Cell   66(2) 383-394   Jul 1991   [Refereed]
Surveying cis-acting sequences of pre-mRNA by adding antisense 2'-O-methyl oligoribonucleotides to a splicing reaction.
Mayeda A, Hayase Y, Inoue H, Ohtsuka E, Ohshima Y
Journal of biochemistry   108 399-405   Sep 1990   [Refereed]
Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro.
Mayeda A, Ohshima Y
Molecular and cellular biology   8 4484-4491   Oct 1988   [Refereed]
Mayeda A, Tatei K, Kitayama H, Takemura K, Ohshima Y
Nucleic acids research   14(7) 3045-3057   Apr 1986   [Refereed]
Ohshima Y, Tatei K, Takemura K, Mayeda A, Kitayama H
Advances in biophysics   21 255-265   1986   [Refereed]
U1 RNA-protein complex preferentially binds to both 5' and 3' splice junction sequences in RNA or single-stranded DNA.
Tatei K, Takemura K, Mayeda A, Fujiwara Y, Tanaka H, Ishihama A, Ohshima Y
Proceedings of the National Academy of Sciences of the United States of America   81 6281-6285   Oct 1984   [Refereed]

Misc

 
Kataoka N, Mayeda A, Ohno K
Frontiers in molecular biosciences   6 53   Jul 2019   [Refereed]
福村和宏, 前田明
実験医学   34(19) 3116‐3121   Dec 2016
Maname T, Mayeda A
Rinshokensa   55(9) 893-899   Sep 2011
Mayeda A, Manabe T, Ohe K
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(16) 2245-2250   Dec 2009   [Refereed]
Mayeda A, Suzuki H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   48(4) 404-413   Mar 2003   [Refereed]
Mayeda A
Saibokogaku. Cell Technology   17(10) 1526-1533   Oct 1998

Books etc

 
Akila Mayeda (Part:Contributor, Chapter 30 In vitro splicing assays)
Wiley-VCH   Feb 2012   ISBN:3527326065

Research Grants & Projects

 
JSPS: Grant-in-Aid for Scientific Research (B) (24310161)
Project Year: Apr 2012 - Mar 2016    Investigator(s): Akila Mayeda
Search for the rationale of aberrant protein generation in cancer cells
Takeda Science Foundation: Visionally Research Fund Renewal (2011 Hop)
Project Year: 2013 - 2015    Investigator(s): Akila Mayeda
MEXT: Grant-in-Aid for Scientific Research on Innovative Areas ‘RNA regulation’ (23112722)
Project Year: Apr 2011 - Mar 2013    Investigator(s): Akila Mayeda
Search for the rationale of aberrant protein generation in cancer cells
Takeda Science Foundation: Visionally Research Fund
Project Year: 2011 - 2012    Investigator(s): Akila Mayeda
JSPS: Grant-in-Aid for Challenging Exploratory Research (20651051)
Project Year: Apr 2008 - Mar 2011    Investigator(s): Akila Mayeda
Evolutional analysis of intron-length and splicing-type using global genomic databases
The Okawa Foundation for Information and Telecommunications: Research Grant (08-16)
Project Year: 2008 - 2009    Investigator(s): Akila Mayeda
Pre-mRNA splicing mechanism of human Dystrophin gene
The Novartis Foundation Japan for the Promotion of Science: Research Grant
Project Year: 2008 - 2009    Investigator(s): Akila Mayeda
HMGA1 proteins as novel RNA-binding factors causing aberrant splicing
NIH–NIGMS: R01 grant (GM081596-01; not available for 2007-2011 in Japan)
Project Year: 2007 - 2007    Investigator(s): Akila Mayeda
HMGA1 as a potential aberrant splicing modulator in breast cancer related genes
UM/Sylvenster Braman Family Breast Cancer Research Institute: Developmental Research Grant
Project Year: 2005 - 2007    Investigator(s): Akila Mayeda
Role of HMGA1 protein in the aberrant splicing of cancer-related genes
SCCC (Sylvenster Comprehensive Cancer Center): Developmental Research Grant
Project Year: 2003 - 2004    Investigator(s): Akila Mayeda
Regulation of Constitutive and Alternative Pre-mRNA Splicing of Human Genes
FDH (Florida Department of Health): Biomedical Research Program (DOH00-035)
Project Year: 2001 - 2004    Investigator(s): Akila Mayeda
Mechanisms of Dystrophin Pre-mRNA Splicing
MDA (Muscular Dystrophy Association): New Investigator Development Grant
Project Year: 2001 - 2004    Investigator(s): Akila Mayeda
Regulation of pre-mRNA Splicing by Splicing Activator RNPS1
ACS (American Cancer Society): Institutional Research Grant (IRG-98-277-04)
Project Year: 2001 - 2002    Investigator(s): Akila Mayeda
Human Frontier Science Program Organization: Long-term Research Fellowship
Project Year: 1991 - 1993    Investigator(s): Akila Mayeda
The Long Island Biological Association (LIBA): LIBA Postdoctoral Fellowship
Project Year: 1990 - 1991    Investigator(s): Akila Mayeda

Teaching Experience

 
 

Conference Activities & Talks

 
EJC core represses cancer-specific mature mRNA re-splicing–EJC as a signal to terminate splicing.
Obtain Y, Kameyama T, Venhuizen P, Kalyna M, Mayeda A.
Eukaryotic mRNA Processing Meeting, Cold Spring Harbor Laboratory, New York, U.S.A.   Aug 2019   
A distinct subset of human short introns with weak pyrimidine tract: U2AF heterodimer is replaced by SPF45/RBM17 as general splicing factor.
Fukumura K, Yoshimoto R, Hirose T, Inoue K, Mayeda A.
The 24th Annual Meeting of the RNA Society, Kraków, Poland.   Jun 2019   
Repressors of cancer-specific mRNA re-splicing: Key factors for splicing fidelity or mRNA quality control?
Mayeda A.
Annual Congress of Taiwan Society of Otorhinolaryngology Head and Neck Surgery / Taiwan Academy of Otology, Taichung, Taiwan.   May 2019   
What is a key factor for precise pre-mRNA splicing?
Mayeda A.
Invited Seminar, Academia Sinica (2019). Taipei, Taiwan.   May 2019   
Identification of tumor suppressor RBM4a as a repressor of cancer-specific mature mRNA re-splicing.
Kameyama T, Fukumura K, Nakatani M, Ohtani Y, Inoue K, Hirose T, Mayeda A.
Cold Spring Harbor Asia Conference: RNA Biology, Dushu Lake Conference Hotel, Suzhou, China.   Oct 2018   
ciRS-7 is biosynthesized using back-splicing promoted by inverted MIR elements and is exported to cytoplasm via Tap/p15 pathway.
Yoshimoto R, Taniguchi I, Ohno M, Mayeda A.
Cold Spring Harbor Asia Conference: RNA Biology, Dushu Lake Conference Hotel, Suzhou, China.   Oct 2018   
40 Years of mRNA Splicingー35 Years of My Studies
Mayeda A.
40 Years of mRNA Splicing: From Discovery to Therapeutics, Cold Spring Harbor Laboratory, New York, U.S.A.   Oct 2017   
The PSAP complex is a global guardian of pre-mRNA splicing fidelity.
Fukumura K, Mayeda A.
Gordon Research Conference: Post-Transcriptional Gene Regulation, Jordan Hotel at Sunday River, Newry, Maine, U.S.A.   Jul 2018   
U2AF is replaced by SPF45 as general splicing factor to recognize weak pyrimidine tract and promotes splicing of human short introns.
Fukumura K, Yoshimoto R, Hirose T, Inoue K, Mayeda A.
The 23th Annual Meeting of the RNA Society, University of California–Berkeley, Berkeley, California, U.S.A.   May 2018   
A repressor candidate of cancer specific mRNA re-splicing: a key factor for splicing fidelity or mRNA quality control.
Kameyama T, Fumura K, Inoue K, Hirose T, Mayeda A.
The 22th Annual Meeting of the RNA Society / International Symposium on the Hallmarks of Cancer: Focus on RNA, Prague, Czech Republic.   May 2017   
Pre-mRNA splicing generates not only linear conding RNA (mRNA), but also circular non-coding RNA (circRNA).
Mayeda A.
Mini-Symposium on ncRNA, Academia Sinica (Taiwan)   Sep 2016   
Considerable implications in unexpectedly prevalent multi-step splicing.
Mayeda A.
RNA Symposium 2016, National Cheng Kung University (Taiwan)   Sep 2016   
The EJC as a master regulator of efficient and faithful splicing involved in mitotic cell cycle progression.
Fukumura K, Wakabayashi S, Kataoka N, Sakamoto H, Suzuki Y, Nakai K, Mayeda A, Inoue K.
The 21th Annual Meeting of the RNA Society / The 18th Annual Meeting of the RNA Society of Japan   Jun 2016   
Cisplatin-stimulated cancer-specific mature mRNA re-splicing is under the control of tumor suppressor p53.
Kameyama T, Amemoto Y, Mayeda A.
The 21th Annual Meeting of the RNA Society / The 18th Annual Meeting of the RNA Society of Japan   Jun 2016   
The functional circular RNA, ciRS-7/CDR1as, is biosynthesized from back-splicing promoted by Inverted MIR (not Alu) Elements.
Yoshimoto R, Hansen T B, Kjems J, Mayeda A.
The 21th Annual Meeting of the RNA Society / The 18th Annual Meeting of the RNA Society of Japan   Jun 2016   
Topological constraint and solution to generate circular RNA (circRNA) from linear RNA (pre-mRNA).
Mayeda A.
NAIST International Workshop ‘New era of pre-mRNA splicing world’   Mar 2016   
The evidence that the ciRS-7/CDR1as (circRNA sponge for miR-7) is generated from re-splicing of lariat RNA, but not from back-splicing.
Yoshimoto R, Kameyama T, Hansen T.B, Kjems J, Mayeda A.
Eukaryotic mRNA Processing Meeting, Cold Spring Harbor Laboratory   Aug 2015   
Ultra-short G-rich introns with completely inefficient 5’ and 3’ splice sites are spliced in vivo, but how?
Shimada M.K, Sasaki-Haraguchi N, Mayeda A.
Eukaryotic mRNA Processing Meeting   Aug 2015   
Hypoxia had an effect on cancer-specific mature mRNA re-splicing.
Kameyama M, Matsumiya S, Mayeda A.
Eukaryotic mRNA Processing Meeting   Aug 2015   
Novel mRNA re-splicing event: Important aspects for understanding robustness and catastrophe in gene expression systems.
Mayeda A.
RIKEN Symposium / The 15th Tokyo RNA Club   Oct 2014   
Novel mRNA re-splicing event as potential paradigm for understanding robustness and catastrophe in gene expression systems.
Kameyama T, Shiroki R, Emi N, Mayeda A.
The 2nd International Symposium on dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions   Jan 2014   
Switching of hnRNP L to hnRNP LL converts PTB-mediated exon exclution to inclusion in a congenital myasthenic syndrome.
Mayeda A, Alinoor Rahman M, Masuda A, Ohe K, Ito M, Hutchinson D.O, Engel A.G, Ohno K.
Eukaryotic mRNA Processing Meeting   Aug 2013   
Ohe K, Miyajima S, Kuwasako K, Muto Y, Utsumi T, Hagiwara M, Mayeda A.
Eukaryotic mRNA Processing Meeting   Aug 2013   
Splicing of Alzheimer’s disease: discovery, mechanism of action, therapeutic insights, and biological significance.
Mayeda A.
BRI International Symposium 2013: RNA World in Brain   Jul 2013   
Resplicing of mature mRNA in cancer cells: Indication of the hidden splicing termination mechanism in normal cells.
Kameyama T, Mayeda A.
BRI International Symposium 2013: RNA World in Brain   Jul 2013   
Pre-mRNA splicing of human ultra-short introns: Are G-rich introns spliced without forming lariat structures?
Mayeda A.
Cold Spring Harbor Asia Conference ‘RNA Biology’   2012   
Mayeda A.
Gordon Research Conference on the Biology of Post-Transcriptional Gene Regulation   Jun 2012   
Resplicing of mature mRNA in cancer cells: Two-step splicing mechanism to activate far distant alternative splice sites.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2011   
Aberrant splicing by an activation of the 5' and 3' cryptic splice sites in the far distant exons takes place after the normal constitutive splicing.
Mayeda A.
Gordon Research Conference on the Biology of Post-Transcriptional Gene Regulation   2010   
Pre-mRNA micro-introns in the human genome: Are they spliced by the massive spliceosome?
Mayeda A.
The 15th Annual Meeting of the RNA Society   2010   
HMGA1a induces aberrant splicing of estrogen receptor α—increasing mRNA but decreasing protein product.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2009   
Aberrant re-splicing of mature spliced mRNA: What is splicing-termination mechanism hidden?
Mayeda A.
Eukaryotic mRNA Processing Meeting   Dec 2009   
The shared mechanism triggered by aberrant U1 snRNP binding modulate the post-transcriptional pathway.
Mayeda A.
The 14th Annual Meeting of the RNA Society   2009   
A novel function of the oncogene product HMAGA1a: Site-specific RNA-binding leading to aberrant exon skipping found in sporadic Alzheimer’s disease.
Akila Mayeda
第21回 内藤コンファレンス   2008   
Molecular mechanism of aberrant exon-skipping mediated by U1 snRNP–HMGA1a complex binding.
Mayeda A.
Gordon Research Conference on the Biology of Post-Transcriptional Gene Regulation   2008   
The mechanism of aberrant exon-skipping mediated by atypical U1 snRNP-HMGA1a complex binding.
Mayeda A.
The 13th Annual Meeting of the RNA Society   2008   
Introns in a large intron: who can define real introns?
Mayeda A.
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress   2006   
RNase R-digested cellular RNA source: Potential use for an intronic cDNA library.
Mayeda A.
The 11th Annual Meeting of the RNA Society   2006   
Evidence that supports nested splicing, introns in a large intron.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2005   
HMGA1a-mediated epigenetic mechanism of splicing defects.
Mayeda A.
The 10th Annual Meeting of the RNA Society   2005   
Minimal model pre-mRNA substrate of two-step recursive splicing in vitro.
Mayeda A.
The 9th Annual Meeting of the RNA Society   2004   
A novel pre-mRNA splicing mechanism of extremely long introns.
Mayeda A.
International Symposium RNA 2003 Kyoto–The New Frontier of RNA Science   2003   
HMGA1a is a potential sequence-specific exon skipping factor.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2003   
Nested introns in a long intron.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2003   
Human RNPS1, as a versatile regulator of alternative pre-mRNA splicing.
Mayeda A.
The 8th Annual Meeting of the RNA Society   2003   
HMGI: A novel exon-skipping factor of Presenilin-2 pre-mRNA in sporadic Alzheimer’s disease.
Mayeda A.
The 7th Annual Meeting of the RNA Society   2002   
Regulation of human RNPS1 activity by phosphorylation.
Mayeda A.
Eukaryotic mRNA Processing Meeting   2001   
Functional analysis of human splicing activator RNPS1.
Mayeda A.
Annual Meeting of the RNA Society of Japan   2001   
Are HRH1 and ATP sufficient for disassembly of spliceosome after mRNA splicing?
Mayeda A.
The 5th Annual Meeting of the RNA Society   2000   
Functionally interacting factors with human RNPS1: A general pre-mRNA splicing activator.
Mayeda A.
Eukaryotic mRNA Processing Meeting   1999   
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing.
Mayeda A.
Eukaryotic mRNA Processing Meeting   1999   
Characterization of SSF; a serine-rich pre-mRNA splicing factor.
Mayeda A.
The 3rd Annual Meeting of the RNA Society   1998   
Characterization of SF7A; a serine-rich splicing factor.
Mayeda A.
Eukaryotic mRNA Processing Meeting   1997   
SF7A: a serine-rich alternative, and possible general, pre-mRNA splicing factor.
Mayeda A.
The 2nd Annual Meeting of the RNA Society   1997   
RRMs define substrate specificity of SR protein in constitutive splicing.
Mayeda A.
The 1st Annual Meeting of the RNA Society   1996   
Purification and characterization of human SF7, an activity that promotes the use of distal alternative 3’ splice sites.
Mayeda A.
RNA Processing Meeting   1995   
Comparative functional analysis of human hnRNP proteins A1, A1B, A2, and B1.
Mayeda A.
RNA Processing Meeting of The RNA Society   1994   
Protein factors that regulate alternative pre-mRNA splice site selection. Mayeda A, Munroe SH, Krainer AR.
Mayeda A.
RNA Processing Meeting   1993   
The human splicing factors SF2 and SC35 are distinct members of the same protein family and have similar properties in vitro.
Mayeda A.
RNA Processing Meeting   1992   
Protein factors that control the specificity of splice site selection: Implications for alternative splicing and inappropriate exon skipping.
Mayeda A.
RNA Processing Meeting   1992   
Characterization and cloning of human essential splicing factor SF2.
Mayeda A.
RNA Processing Meeting   1991   
Identification and characterization of human SF5, an activity that promotes the use of distal 5’ splice sites during alternative pre-mRNA splicing in vitro.
Mayeda A.
RNA Processing Meeting   1991   
Surveying cis-acting sequences of pre-mRNA by adding antisense 2’-O-Me RNA to a splicing reaction.
Mayeda A.
RNA Processing Meeting   1990   
Are exon sequences and intron position important in pre-mRNA splicing?
Mayeda A.
RNA Processing Meeting   1989