論文

2022年8月

HLA analysis of immune checkpoint inhibitor-induced and idiopathic isolated ACTH deficiency

Pituitary
  • Mayo Ono
  • Izumi Fukuda
  • Mototsugu Nagao
  • Keiko Tomiyama
  • Mikiko Okazaki-Hada
  • Yuki Shuto
  • Shunsuke Kobayashi
  • Yuji Yamaguchi
  • Tomoko Nagamine
  • Yasushi Nakajima
  • Kyoko Inagaki-Tanimura
  • Hitoshi Sugihara
  • 全て表示

25
4
開始ページ
615
終了ページ
621
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11102-022-01231-1

Purpose: Isolated adrenocorticotropic hormone deficiency is a rare disease; however, since immune check point inhibitors (ICIs) have become widely used, many more cases have been reported. In this study, we compared the human leukocyte antigen (HLA) signatures between ICI-induced isolated adrenocorticotropic hormone deficiency (IAD) and idiopathic IAD (IIAD). Design and methods:: Clinical features and HLA frequencies were compared among 13 patients with ICI-induced IAD, 8 patients with IIAD, and healthy controls. HLA frequencies of healthy controls were adopted from a HLA database of Japanese population. Results: Age and body mass index were higher, while the rate of weight loss was lower, in patients with ICI-induced IAD than in those with IIAD. No HLA alleles had a significantly higher frequency in patients with ICI-induced IAD than in healthy controls, whereas the frequencies of HLA-DRB1*09:01, HLA-DQA1*03:02, and DQB1*03:03 were significantly higher in patients with IIAD than in healthy controls. Conclusions: ICI-induced IAD and IIAD were different in terms of HLA frequencies. There were no specific HLAs related to ICI-induced IAD, whereas several HLAs in strong linkage disequilibrium were associated with IIAD. This might suggest that the two diseases have different pathological mechanisms. HLAs unique to IIAD may be helpful in predicting its pathophysiology.

リンク情報
DOI
https://doi.org/10.1007/s11102-022-01231-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35653047
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131308176&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85131308176&origin=inward
ID情報
  • DOI : 10.1007/s11102-022-01231-1
  • ISSN : 1386-341X
  • eISSN : 1573-7403
  • PubMed ID : 35653047
  • SCOPUS ID : 85131308176

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