論文

査読有り
2015年6月

Effects of Fok-I polymorphism in vitamin D receptor gene on serum 25-hydroxyvitamin D, bone-specific alkaline phosphatase and calcaneal quantitative ultrasound parameters in young adults

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
  • Rieko Tanabe
  • ,
  • Yuka Kawamura
  • ,
  • Naoko Tsugawa
  • ,
  • Mayu Haraikawa
  • ,
  • Natsuko Sogabe
  • ,
  • Toshio Okano
  • ,
  • Takayuki Hosoi
  • ,
  • Masae Goseki-Sone

24
2
開始ページ
329
終了ページ
335
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.6133/apjcn.2015.24.2.01
出版者・発行元
H E C PRESS, HEALTHY EATING CLUB PTY LTD

Several genes have been implicated as genetic determinants of osteoporosis. Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D-3 [1, 25(OH)(2)D], and mediates its effects. One of the most frequently studied single nucleotide polymorphisms is the restriction fragment length polymorphism (RFLP) Fok-I (rs2228570). The presence of a Fok-I site, designated f, allows protein translation to initiate from the first ATG. An allele lacking the site (ATG>ACG: designated F), initiates from a second ATG site. In the present study, we explored the effect of the VDR Fok-I genotype on associations among serum bone-specific alkaline phosphatase (ALP), 25-hydroxyvitamin D-3 [25(OH)D], 1, 25(OH)(2)D, and the dietary nutrient intake in healthy young Japanese subjects (n=193). Dietary nutrient intakes were calculated based on 3-day food records before the day of blood examinations. Quantitative ultrasound (QUS) parameters at the right calcaneus (heel bone) were measured. The allele frequencies were 0.622 for the F allele and 0.378 for the f allele in all subjects. Grouped by the VDR genotype, a significant positive correlation between the levels of serum bone-specific ALP and 25(OH)D was observed in the FF-type (p=0.005), but not in the if-type. In addition, there was a significant positive correlation between the level of serum 25(OH)D and osteo-sono assessment index (OSI) in the FF-type (p=0.008), but not in the if-type. These results suggest that the level of circulating 25(OH)D is an important factor when assessing the VDR Fok-I polymorphism to prevent osteoporosis.

リンク情報
DOI
https://doi.org/10.6133/apjcn.2015.24.2.01
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26078251
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000357700300018&DestApp=WOS_CPL
ID情報
  • DOI : 10.6133/apjcn.2015.24.2.01
  • ISSN : 0964-7058
  • PubMed ID : 26078251
  • Web of Science ID : WOS:000357700300018

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