2009年1月
AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse
NUCLEIC ACIDS RESEARCH
- ,
- ,
- ,
- ,
- 巻
- 37
- 号
- 開始ページ
- D305
- 終了ページ
- D309
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/nar/gkn869
- 出版者・発行元
- OXFORD UNIV PRESS
We have constructed a database, AS-ALPS (alternative splicing-induced alteration of protein structure), which provides information that would be useful for analyzing the effects of alternative splicing (AS) on protein structure, interactions with other bio-molecules and protein interaction networks in human and mouse. Several AS events have been revealed to contribute to the diversification of protein structure, which results in diversification of interaction partners or affinities, which in turn contributes to regulation of bio-molecular networks. Most AS variants, however, are only known at the sequence level. It is important to determine the effects of AS on protein structure and interaction, and to provide candidates for experimental targets that are relevant to network regulation by AS. For this purpose, the three-dimensional (3D) structures of proteins are valuable sources of information; however, these have not been fully exploited in any other AS-related databases. AS-ALPS is the only AS-related database that describes the spatial relationships between protein regions altered by AS ('AS regions') and both the proteins' hydrophobic cores and sites of inter-molecular interactions. This information makes it possible to infer whether protein structural stability and/or protein interaction are affected by each AS event. AS-ALPS can be freely accessed at http://as-alps.nagahama-i-bio.ac.jp and http://genomenetwork.nig.ac.jp/as-alps/.
- リンク情報
- ID情報
-
- DOI : 10.1093/nar/gkn869
- ISSN : 0305-1048
- PubMed ID : 19015123
- Web of Science ID : WOS:000261906200055