Mitsuhiro Hashimoto

J-GLOBAL         Last updated: Jun 21, 2019 at 13:35
Mitsuhiro Hashimoto
Fukushima Medical University


I find that an adenoviral vector can introduce a foreign gene into neurons in a neuronal birthdate specific manner. The nature of an adenoviral vector is very useful for stadying the neuronal development and function, because we can examine and modify a subet of neurons that share the same birthdate. Using the adenoviral vector system, I would like to examine the link between the neuronal birthdate and the neuronal function.
 Using an adenoviral vector, I label Purkinje cells (PCs) born at embryonic day (E)10.5, E11.5, and E12.5 and trace their fated positions in the mouse cerebellum. As a result, I find that each cohort of birthdate-related PCs forms longitudinal compartments in the cerebellum, and furthermore, these compartments formed by each cohort of birthdate-related PCs correlate strikingly with olivocerebellar projection. It suggests that there is close correlation between birthdate of PCs and the formation of cerebellar neuronal network. I would like to examine the correlation between the neuronal birthdates of PCs and cerebellar functions.

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Academic & Professional Experience

Apr 2015
assistant prof., Dept. of Neuroanatomy and Embryology, Fukushima Med. Univ.I
Jul 2011
Mar 2015
Assistant professor, Department of Anatomy and Cell biology, Nagoya Univ.
Jun 2004
Nov 2011
Unit Leader (PI), RIKEN BSI, Hashimoto Research Unit
Nov 1997
May 2004
Researcher, RIKEN BSI
Apr 1996
Mar 1997
postdoctoral fellowship, RIKEN

Published Papers

Mitsuhiro Hashimoto, Akihiro Yamanaka, Shigeki Kato, Manabu Tanifuji, Kazuto Kobayashi and Hiroyuki Yaginuma
Frontiers in Neural Circuits   12(6) 1-20   Feb 2018   [Refereed]
Mitsuhiro Hashimoto and Masahiko Hibi
Develop. Growth Differ.   54 373-389   2012   [Refereed][Invited]
Hashimoto, Mitsuhiro; Ito, Rie; Kitamura, Naohito; Hisano, Yasuko
The Journal of Comparative Neurology   520(8) 1702-1720   Apr 2012   [Refereed]
Yamada Y, Michikawa T, Hashimoto M, Horikawa K, Nagai T, Miyawaki A, Hausser M, Mikoshiba K
Frontiers in Cellular Neuroscience   5 18   Sep 2011   [Refereed]


Mechanisms of cerebellar development and differentiation.
Mitsuhiro Hashimoto
Neurological Medicine   78(6) 619-626   Jun 2013   [Invited]
Mitsuhiro Hashimoto
Handbook of Neurochemistry and Molecular Neurobiology: Neural Signaling Mechanisms, Ed. Mikoshiba, K.   19 16-24   2009   [Invited]

Research Grants & Projects

Project Year: Apr 2013 - Mar 2016    Investigator(s): Mitsuhiro Hashimoto
National Institute for Physiological Science: General collaborative project
Project Year: Apr 2012 - Mar 2013    Investigator(s): Mitsuhiro Hashimoto
Project Year: 2004 - 2009    Investigator(s): Hensch, Takao
Strategic Exploitation of Neuro-Genetics for Emergence of the Mind
Bureau of Science and Technology poicy: Funding Program for World-Leading Innovative R&D on Science and Technology (FIIST)
Investigator(s): Okano, Hideyuki