Mitsuhiro Hashimoto

I find that an adenoviral vector can introduce a foreign gene into neurons in a neuronal birthdate specific manner. The nature of an adenoviral vector is very useful for studying neuronal development and function because we can examine and modify a subset of neurons that share the same birthdate. Using the adenoviral vector system, I would like to examine the link between the neuronal birthdate and neuronal function.
Using an adenoviral vector, I label Purkinje cells (PCs) born at embryonic day (E)10.5, E11.5, and E12.5 and trace their fated positions in the mouse cerebellum. As a result, I find that each cohort of birthdate-related PCs forms longitudinal compartments in the cerebellum, and furthermore, these compartments formed by each cohort of birthdate-related PCs correlate strikingly with olivocerebellar projection. It suggests that there is a close correlation between the birthdate of PCs and the formation of the cerebellar neuronal network. I would like to examine the correlation between the neuronal birthdates of PCs and cerebellar functions.

Publons: https://publons.com/researcher/2823717/mitsuhiro-hashimoto/
Personal HP: https://mhashimoto.main.jp/
(Sorry, the personal home page is written in Japanese. I will open the English version of it.)