論文

査読有り 国際誌
2023年6月1日

Adverse effects of contamination by fipronil and its derivatives on growth, molting, and gene expression in the mysid crustacean, Americamysis bahia, in Japanese estuaries.

The Science of the total environment
  • Masaya Uchida
  • ,
  • Hazuki Mizukawa
  • ,
  • Masashi Hirano
  • ,
  • Nobuaki Tominaga
  • ,
  • Koji Arizono
  • ,
  • Hiroshi Ishibashi

開始ページ
164595
終了ページ
164595
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.scitotenv.2023.164595

Concentrations of fipronil (Fip) and several of its derivatives were detected in samples from four rivers and four estuaries in Japan. LC-MS/MS analysis detected Fip and its derivatives, except for fipronil detrifluoromethylsulfinyl, in almost all samples. The total concentrations of the five compounds were approximately two-fold greater in river water (mean: 21.2, 14.1, and 9.95 ng/L in June, July, and September, respectively) compared to those in estuarine water (mean: 10.3, 8.67, and 6.71 ng/L, respectively). Fipronil, fipronil sulfone (FipS), and fipronil sulfide (FipSf) represented more than 70 % of all compounds. This is the first report to demonstrate the contamination of estuarine waters of Japan by these compounds. We further investigated the potentially toxic effects of Fip, FipS, and FipSf on the exotic mysid, Americamysis bahia (Crustacea: Mysidae). The lowest effective concentrations of Fip-S (10.9 ng/L) and FipSf (19.2 ng/L) on mysid growth and molting was approximately 12.9- and 7.3-fold lower than Fip (140.3 ng/L), suggesting they had higher toxicity. Quantitative reverse transcription polymerase chain reaction analysis revealed that ecdysone receptor and ultraspiracle gene expression were not affected after 96-h of exposure to Fip, Fip-S, and Fip-Sf, suggesting that these genes may not be involved in the molting disruption induced by Fip, Fip-S, and Fip-Sf. Our findings suggest that environmentally relevant concentrations of Fip and its derivatives can disrupt the growth of A. bahia by promoting molting. However, further studies are required to elucidate its molecular mechanism.

リンク情報
DOI
https://doi.org/10.1016/j.scitotenv.2023.164595
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/37270003
ID情報
  • DOI : 10.1016/j.scitotenv.2023.164595
  • PubMed ID : 37270003

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