2018年8月6日
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria.
The Journal of experimental medicine
- 巻
- 215
- 号
- 8
- 開始ページ
- 2019
- 終了ページ
- 2034
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1084/jem.20180427
Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF). In both mice and humans, MAFF is detected predominantly in mucus-resident bacteria, and its expression requires the presence of complex microbiota. Expression of the MAFF system facilitates symbiosis with other members of the phylum Firmicutes and promotes protection from a chemically induced model of colitis. Our data reveal a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.
- リンク情報
- ID情報
-
- DOI : 10.1084/jem.20180427
- ISSN : 0022-1007
- PubMed ID : 30042191
- PubMed Central 記事ID : PMC6080902