2010年2月
Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- 巻
- 34
- 号
- 1
- 開始ページ
- 10
- 終了ページ
- 17
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.pnpbp.2009.09.004
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Background: Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects.
Methods: Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 24 females) age- and parental socio-economic status-matched healthy subjects. Twenty-nine regions of interest (ROI) were measured on 1-mm-thick coronal slices from the prefrontal and central parts of the brain. Linear discriminant function analysis was conducted using standardized z scores of the volumes of each ROI.
Results: Discriminant function analysis with cross-validation procedures revealed that brain anatomical variables correctly classified 75.6% of male subjects and 82.9% of female subjects, respectively. The results of the volumetric comparisons of each ROI between patients and controls were generally consistent with those of the previous literature.
Conclusions: To our knowledge, this study provides the first evidence of MRI-based successful classification between first-episode patients with schizophrenia and healthy controls. The potential of these methods for early detection of schizophrenia should be further explored. (C) 2009 Elsevier Inc. All rights reserved.
Methods: Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 24 females) age- and parental socio-economic status-matched healthy subjects. Twenty-nine regions of interest (ROI) were measured on 1-mm-thick coronal slices from the prefrontal and central parts of the brain. Linear discriminant function analysis was conducted using standardized z scores of the volumes of each ROI.
Results: Discriminant function analysis with cross-validation procedures revealed that brain anatomical variables correctly classified 75.6% of male subjects and 82.9% of female subjects, respectively. The results of the volumetric comparisons of each ROI between patients and controls were generally consistent with those of the previous literature.
Conclusions: To our knowledge, this study provides the first evidence of MRI-based successful classification between first-episode patients with schizophrenia and healthy controls. The potential of these methods for early detection of schizophrenia should be further explored. (C) 2009 Elsevier Inc. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.pnpbp.2009.09.004
- CiNii Articles
- http://ci.nii.ac.jp/naid/10029842027
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19751790
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000274563400003&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.pnpbp.2009.09.004
- ISSN : 0278-5846
- CiNii Articles ID : 10029842027
- PubMed ID : 19751790
- Web of Science ID : WOS:000274563400003