論文

査読有り
2020年2月18日

Hepatic neuroendocrine carcinoma with metastases to the lymph nodes in a sika deer (Cervus nippon yakushimae).

The Journal of veterinary medical science
  • Ritsu Shibata
  • ,
  • Yukino Machida
  • ,
  • Hitoshi Hatakeyama
  • ,
  • Hisashi Yoshimura
  • ,
  • Masami Yamamoto
  • ,
  • Kazuhiko Ochiai
  • ,
  • Kazuyoshi Uematsu
  • ,
  • Masaki Michishita

82
2
開始ページ
193
終了ページ
196
記述言語
英語
掲載種別
DOI
10.1292/jvms.19-0472

A 26-year and 6-month-old male sika deer that was kept at the Showa Park, Tokyo, Japan, collapsed and died of severe disease wasting and severe tabefaction. Grossly, numerous masses, 0.3-1.0 cm diameter, were dispersed throughout the liver. The multiple masses were composed of tumor cells, which had hypochromatic nuclei and abundant faintly eosinophilic cytoplasm, arranged in nests of various sizes. Immunohistochemically, tumor cells were positive for cytokeratin, chromogranin A, synaptophysin and gastrin. Ultrastructurally, the cytoplasm of the tumor cells contained abundant membrane-bound electron-dense granules. A metastatic lesion was observed in the renal, hepatic and pancreatic lymph nodes. On the basis of these findings, this tumor was diagnosed as a neuroendocrine carcinoma with metastases to the lymph nodes.

リンク情報
DOI
https://doi.org/10.1292/jvms.19-0472
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31902801