論文

査読有り
2016年8月

Denervation-Associated Change in the Palatinus and Levator Veli Palatini Muscles of Dogs with Elongated Soft Palate

JOURNAL OF COMPARATIVE PATHOLOGY
  • K. Arai
  • ,
  • K. Takahashi
  • ,
  • A. Yasuda
  • ,
  • N. Kanno
  • ,
  • Y. Kohara
  • ,
  • M. Michishita
  • ,
  • Y. Harada
  • ,
  • Y. Hara

155
2-3
開始ページ
199
終了ページ
206
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jcpa.2016.06.010
出版者・発行元
ELSEVIER SCI LTD

Muscle lesions and decreased numbers of peripheral nerve branches have been reported in the soft palates of dogs presenting with brachycephalic airway obstruction syndrome (BAOS). Myosin adenosine triphosphatase staining was employed to investigate whether muscle lesions in the elongated soft palate (ESP) of dogs with BAOS reflect the presence of denervation. Soft palates were collected from nine brachycephalic dogs during surgical intervention for BAOS and from five healthy beagle dogs as controls. In the control soft palates, myofibres with relatively uniform diameters and a random mosaic pattern of type I and II myofibres were observed in the palatinus muscle (PM), while almost all of the myofibres in the levator veli palatini muscle (LVPM) were of type II. In the ESPs, small group atrophy, large group atrophy and angular-shaped atrophy were observed in myofibres of the PM and rarely in the LVPM. Fibre type grouping and an increase in type IIC myofibres were found only in the PM. Morphometric analysis of ESPs revealed a significant increase in the number of type I and II myofibres in the PM showing atrophy or hypertrophy compared with controls. A significant increase in atrophic type II myofibres was found in the LVPM of affected dogs. Myopathy consistent with denervation was observed in the PM, but rarely in the LVPM, of ESP specimens. The results suggest that the myopathy seen in dogs with ESP may partly reflect atrophy of myofibres resulting from damage to peripheral nerve branches, with subsequent reinnervation of myofibres. (C) 2016 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.jcpa.2016.06.010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27426002
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383931200015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jcpa.2016.06.010
  • ISSN : 0021-9975
  • eISSN : 1532-3129
  • PubMed ID : 27426002
  • Web of Science ID : WOS:000383931200015

エクスポート
BibTeX RIS