Michiyo Tsuru

J-GLOBAL         Last updated: May 20, 2019 at 17:41
 
Avatar
Name
Michiyo Tsuru
E-mail
michiyomed.kurume-u.ac.jp
Affiliation
Kurume University
Job title
Lecturer, Disease Proteomics Genomics Analysis Center
Degree
Ph.D.(Life Science Dr)

Profile

EXPERIENCE
4/2014 - Present Kurume University
Lecturer, Disease Proteomics Genomics Analysis Center

4/2008 - 3/2014 Kurume University School of Medicine
Assistant Professor, Department of Orthopedics
]
12/2003 - 3/2008 Kurume University
Post-Doctoral Fellow, Bio Statistics Center

7/2003 - 11/2003 Kurume University School of Medicine
Assistant (volunteer), Department of Immunology

9/1999 - 6/2003 Kurume University School of Medicine
Research Assistant, Instructor of Department of Immunology

1/1992 - 8/1999 Kurume University School of Medicine
Research Assistant, Department of Anatomy

2/1989 - 12/1991 National Kyushu Cancer Center
Gastrointestinal Medicine Department

4/1987 - 2/1989 South Omuta Hospital
Clinical Laboratory Department

EDUCATION
4/2004 - 3/2006

9/2003

4/1983 - 3/1987

4/1985 - 3/1987

Master of Biostatistics, Kurume University School of Medicine, Japan

Ph.D. in Life Sciences, Kitasato University Kanagawa, Japan

Kitasato University, Kanagawa, Japan

Department of Physiology, Keio University School of Medicine, Tokyo, Japan
CERTIFICATES - Completed the course for practical skill of working environment measurement experts (Kitazato Health Science Center, No.121) 5/1986
- Public Health Laboratory Technologist (No.45632)10/1987
- Health Supervisor (No. 40000200560) 7/1991
- Industrial disposal site technical manager authorized by Minister of Health, Labour and Welfare (No. 8519) 4/1991
- Industrial disposal site technical manager authorized by Japan Environmental Sanitation Center (No. 32304)

MEMBERSHIPS - Member, Japan Clinical Cancer Research Organization (JACCRO).
- Member, The Japanese Orthopedics Association.
- Member, Japanese Cancer Association.
- Member, The Molecular Biology Society of Japan.
- Member, The Japanese Society for Bone and Mineral Research.

AWARDS - Research Award, Second European Conference on Bone Morphogenetic Proteins. Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice. 2002
- Research Award, Lilly Fellowship and Research Grant Program for Bone & Mineral Research. 2005
- Research Award, AstraZeneca Research Grant. 2006
- New preventative strategy for human bone metastases targeting a specific novel protein.

SHORT BIOGRAPHY - Enforced the intractable diseases from proteomics, and performed cancer conquest drug design research and development.

Research Areas

 
 

Academic & Professional Experience

 
Feb 1989
 - 
Dec 1991
Gastrointestinal Medicine Department, National Kyushu Cancer Center
 

Education

 
2003
 - 
2003
Kitasato University doctor of life sciences
 
Apr 2004
 - 
Mar 2006
Master of Biostatistics, Kurume University School of Medicine
 
Apr 1983
 - 
Mar 1987
Kitasato University
 

Awards & Honors

 
Nov 2018
Clinical study on osteoporosis, Japan Osteoporosis Foundation
 
2006
New preventative strategy for human bone metastases targeting a specific novel protein., Research Award, AstraZeneca Research Grant., Research Award, AstraZeneca Research Grant.
Winner: Tsuru Michiyo
 
2005
Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research., Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research.
Winner: Tsuru Michiyo
 
May 2002
Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice., Research Award, Second European Conference on Bone Morphogenetic Proteins., Research Award, Second European Conference on Bone Morphogenetic Proteins.
Winner: Tsuru Michiyo
 

Published Papers

 
Tsuru M, Ono A, Umeyama H, Takeuchi M, Nagata K
PloS one   13(5) e0196204   2018   [Refereed]
Tsuru M, Sata M, Tanaka M, Umeyama H, Kodera Y, Shiwa M, Aoyagi N, Yasuda K, Matsuoka K, Fukuda T, Yamana H, Nagata K
Translational oncology   10(6) 998-1007   Dec 2017   [Refereed]
The development accompanied by the early detection and treatment of medical treatment strategy (backbone, pelvis, and limbs) cancer metastasis peptides to metastatic bone tumors
Tsuru Michiyo
The Japanese Orthopaedic Association   87(10) 859-864   2013   [Refereed]
The medical treatment results and limit of a preservation treatment over cervical vertebrae amyotrophy (Keegan type upper-limbs movement paralysis)
Tsuru Michiyo
Spine & Spinal Cord   22(10) 1117-1123   2009   [Refereed]
Yokosuka K, Park JS, Jimbo K, Yamada K, Sato K, Tsuru M, Takeuchi M, Yamagishi S, Nagata K
Journal of neurosurgery. Spine   5(4) 324-329   Oct 2006   [Refereed]
Human bone metastasis biomarker discovery and clinical application
Tsuru Michiyo
55(2) 176-179   2006   [Refereed]
Statistical analysis of the distinction factor of a preservation treatment and a surgical operation as opposed to upper-limbs movement paralysis at least in Keegan type
Tsuru Michiyo
Kurume University School of Medicine      Mar 2005   [Refereed]
Establishment-izing of the raw cell stock from human pancreatic cancer PANKURE astatine, and a human cartilage cell stock, and expression by the role of Advanced glycation end products (AGEs) and the macrophage of an AGEs receptor in a bone
Tsuru Michiyo
Kitasato University      Sep 2003   [Refereed]
Tsuru M, Nagata K, Ueno T, Jimi A, Noda S, Iida S, Sata M
The Kurume medical journal   49(1-2) 1-5   2002   [Refereed]
Tsuru M, Nagata K, Jimi A, Irie K, Yamada A, Nagai R, Horiuchi S, Sata M
The Kurume medical journal   49(1-2) 7-13   2002   [Refereed]
Tsuru Michiyo
J Clin Endocr   73(1) 151-155   1991   [Refereed]
Tsuru Michiyo
Biochem Biophs Res Co   168(2) 741-746   1990   [Refereed]
Immunity histological chemistry examination of the carcinogenic gene product in an Ethylnitrosourea indecement brain tumor
Tsuru Michiyo
Kitasato University, Study instruction, Keio University medical department physiology professor Yuzo Tsukada.      Mar 1987   [Refereed]

Misc

 
Michiyo Tsuru
http://www.jsbmr.jp/1st_author/328_mtsuru.html      Sep 2018
TSURU Michiyo, NAGATA Kensei, YAMAGUCHI Takehiko, SATA Michio
55(2) 176-179   Mar 2006
TSURU Michiyo, NAGATA Kensei
55(2) 183-185   Mar 2006
PARK J., YOON Tim S., BODEN Scott
14(1)    Feb 2003
Nishida T., Ueno T., Sata M., Tsuru M., Irie T., Nagata K., Yoshizuka M.
Connective tissue   30(2)    Jun 1998

Books etc

 
Forefront of disease proteomics
2004   ISBN:4-944157-32-7
Spontaneous Remission of Intervertebral Disk Hernia and Responses of Surrounding Macrophages.
Michiyo Tsuru (Part:Joint Work, Advances in Spinal Fusion-Molecular Science, Biomechanics and Clinical Management. Cambridge Scientific, Inc. c/o M&N Toscano)
Advances in Spinal Fusion-Molecular Science, Biomechanics and Clinical Management. Cambridge Scientific, Inc. c/o M&N Toscano   2002   

Conference Activities & Talks

 
Michiyo Tsuru
The 15th Annual Meeting of Japan Society for Clinical Proteogenomics   11 May 2019   
Statistical search method for disease-specific proteins
Michiyo Tsuru
Togo - Japan sponsored by the Japan Science and Technology Agency (JST), Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labor and Welfare Co-organized Research Results Fruitful Report   6 Oct 2016   
Discovery and clinical application of human bone metastasis biomarker from proteomics
Michiyo Tsuru
3rd MEXT Ministry of Health, Labor and Welfare Ministry of Health, Labor and Welfare Innovative Medical Technology Creation Base Project. TR Promotion Joint Forum Medical Innovation from Accademia - Japan and the World -   31 Aug 2015   
Nonclinical proof of concept study to develop a formulation for treatment of longitudinal ligament ossification.
Michiyo Tsuru
3rd MEXT Ministry of Health, Labor and Welfare Ministry of Health, Labor and Welfare Innovative Medical Technology Creation Base Project. TR Promotion Joint Forum Medical Innovation from Accademia - Japan and the World -   31 Aug 2015   
Treatment strategies for metastatic bone tumors (spine, pelvis, limbs) Development studies involving the early detection and early treatment of cancer metastatic peptides. [Invited]
Michiyo Tsuru
The Journal of the Japanese Orthopaedic Association.   2013   
Development study involving early detection and early treatment of cancer metastasis peptides.
Michiyo Tsuru
45th Meeting of the Japanese Academy of Orthopedic Surgeons bone and soft tumor Scientific Meeting   14 Jul 2012   
Discovery of lumbar intervertebral disk regeneration gene
Michiyo Tsuru
The Journal of the Japanese Clinical Orthopaedic Association   2010   
Report on human bone metastasis biomarker clinical trial results
Michiyo Tsuru
5th Japanese the human proteome society   29 Jul 2007   
Efficacy and clinical utility of preclinical trials of bone metastasis biomarkers
Michiyo Tsuru
The 21rd Annual Research Meeting of the Japanese Orthopaedic Association   19 Oct 2006   
Discovery of human bone metastasis biomarker and report on results of multi-center joint test
Michiyo Tsuru
The 79rd Annual Research Meeting of the Japanese Orthopaedic Association   18 Jul 2006   
Discovery of human bone metastasis biomarker from proteomics and its clinical utility
Michiyo Tsuru
2th Annual Meeting of Japan Society for Clinical Proteomics   18 Jul 2006   
Omics analysis in mouse standing environment.
Michiyo Tsuru
Orthopedics & Traumatology   2006   
Discovery and clinical application of human bone metastasis biomarker.
Michiyo Tsuru
Orthopedics & Traumatology   2006   
Discovery and clinical application of human bone metastasis biomarker from proteomics
Michiyo Tsuru
8th cancer and bone lesions Study Group   26 Nov 2005   
Discovery and clinical application of human bone metastasis biomarker from proteomics
Michiyo Tsuru
20th Annual Meeting of the Japanese Cancer Association Meeting   21 Oct 2005   
Mechanism of bone metastasis
Michiyo Tsuru
20th Annual Meeting of the Japanese Cancer Association Meeting   21 Oct 2005   
Bone disease proteomics
Michiyo Tsuru
Disease Forefront of proteomics   2 Sep 2005   
New strategy of cancer research by proteomics Clinical application from bone metastasis proteome analysis
Michiyo Tsuru
63rd Annual Meeting of the Japanese Cancer Association   29 Sep 2004   
Expression of osteogenic genes in intervertebral disc degeneration
Michiyo Tsuru
19th Annual Meeting of the Japanese Cancer Association Meeting   29 Sep 2004   
Spontaneous Remission of Intervertebral Disk Hernia and Responses of Surrounding Macrophages.
Michiyo Tsuru
18th North American Spine Society.   21 Oct 2003   
Elucidation of bone metabolism from cell membrane proteome analysis in human spinal ligament ossification
Michiyo Tsuru
18th Annual Meeting of the Japanese Cancer Association Meeting   16 Oct 2003   
Human stem cell approach from pathology proteomics
Michiyo Tsuru
The 1st Symposium on Proteomics   2003   
Confocal laser microscopy of chondrocytes that received gene transfer using in vitro electroporation.
Michiyo Tsuru
International BMP conference.   25 May 2002   
Gene therapy using in vivo electroporation of the human BMP-2 gene in Klotho mice.
Michiyo Tsuru
International BMP conference   22 May 2002   
Electron microscopic observation of degeneration of chondrocytes and autologous macrophages by human lumbar disc herniation model
Michiyo Tsuru
30th Spine Surgery and Related Research (SSRR)   9 Dec 2001   
Effects of AGEs on human disc herniation and human fetal spinal cord cells
Michiyo Tsuru
30th Spine Surgery and Related Research (SSRR)   9 Dec 2001   
Posterior longitudinal ligament ossification and genome analysis.
Michiyo Tsuru
16th Annual Meeting of the Japanese Cancer Association Meeting   18 Oct 2001   
Posterior longitudinal ligament ossification and genome analysis - focusing on proteome analysis -
Michiyo Tsuru
16th Annual Meeting of the Japanese Cancer Association Meeting   18 Oct 2001   
Effect of cytokine, TGF-beta, anticancer drug administration on human cultured cells as seen from proteome analysis
Michiyo Tsuru
The 61th Annual Meeting of the Japanese Cancer Association   1 Apr 2001   
BMP-2 gene transfer method by in vivo electroporation method
Michiyo Tsuru
The 3rd Klotho Study Group   2001   
Human intervertebral disc herniated chondrocyte (KTN-1); living colors gene analysis by in vitro electroporation
Michiyo Tsuru
23th Japanese Society of Molecular Biology   2001   
Confocal laser microscopic observation of gene transfer into human chondrocytes by in vitro electroporation.
Michiyo Tsuru
16th Annual Meeting of the Japanese Cancer Association Meeting   2001   
Gene therapeutic effect by human BMP-2 in vivo electroporation method in Klotho mouse.
Michiyo Tsuru
16th Annual Meeting of the Japanese Cancer Association Meeting   2001   
Intracellular introduction of bone morphogenetic gene and tissue change.
Michiyo Tsuru
57th The Japanese Society of Microscopy (JSM)   2001   
Proteome analysis for spinal disease repair in Klotho mice
Michiyo Tsuru
101th The journal of West-Japanese Society of Orthopedics & Traumatology.   2001   
BMP-2 gene transfer into Klotho mouse
Michiyo Tsuru
20th Japanese Society for Transplantation and Tissue Engineering in Musculoskeletal System   2001   
From proteome analysis to a genome
Michiyo Tsuru
Japanese Society of Molecular Biology   2001   
Electron microscopic observation of established cell line (KTN-1) chondrocytes derived from human intervertebral disc hernia and macrophages on spontaneous regression of derenerated tissues.
Michiyo Tsuru
Asia-Pacific Orthopaedic Association ”APOA“    2001   
Electron Microscopic Observation of Cultured Chondrocytes and Role of Macrophages on Spontaneous Regression of Herniated Lumbar Intervertebral Disc
Michiyo Tsuru
North American Spine Society Spine Across the Sea   2001   
Effects of AGEs on human disc herniation and human fetal spinal cord cells
Michiyo Tsuru
13th Japanese Society of Cartilage Metabolism   4 Mar 2000   
Electron Microscopic Observation of Human Intervertebral Disc Hernia-derived Cartilage Culture Cell and Autologous Macrophage
Michiyo Tsuru
13th Japanese Society of Cartilage Metabolism   3 Mar 2000   
Purification of Pancreastatin derived from tumor (QGP-1 N) and its biological activity
Michiyo Tsuru
33th THE JAPANESE SOCIETY OF GASTROENTEROLOGY   25 Oct 1991   
Investigation of quantification method of PCR combined CCK mRNA
Michiyo Tsuru
33th THE JAPANESE SOCIETY OF GASTROENTEROLOGY   24 Oct 1991   
Studies on cell growth regulators in cultured pancreatic cancer cells (1st report)
Michiyo Tsuru
50th Japanese Cancer Association   11 Sep 1991   
Studies on cell growth regulators in cultured pancreatic cancer cells (2nd report)
Michiyo Tsuru
50th Japanese Cancer Association   11 Sep 1991   
Studies on cell growth regulators in cultured pancreatic cancer cells: On CCK susceptible strains
Michiyo Tsuru
2th Japanese Society for Gastroenterological Carcinogenesis   1 Sep 1990   
Pancreastatin producing cell line from human pancreatic islet cell tumor.
Tsuru Michiyo
4th The international association of pancreatology (IAP)   20 Aug 1990   
Study of cell growth regulatory factors in cultured pancreatic cancer cells
Tsuru Michiyo
49th Annual Meeting of the Japanese Cancer Association Meeting   4 Jul 1990   
Parallel secretion of pancreastatin and somatostatin from human pancreastatin producing cell line (QGP-1N).
Tsuru Michiyo
American Gastroenterological Association.   13 May 1990   

Works

 
OP-1 Strut Allograft Healing to the Femur with recombinant Human
Nippon Striker Co., Ltd.   The Others   2002
Rheumatoid arthritis clinical trial of hesperidin,
Ezaki Glico Co., Ltd.   The Others   2002
FOY Clinical Trial
Ono Pharmaceutical Co., Ltd.   The Others   1990 - 1991

Research Grants & Projects

 
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2012 - Mar 2016    Investigator(s): Michiyo Tsuru
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2009 - Mar 2014    Investigator(s): Kensei Nagata
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2013       Investigator(s): Kensei Nagata, Michiyo Tsuru
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2012       Investigator(s): Kensei Nagata, Michiyo Tsuru
Project Year: Apr 2007 - Mar 2011    Investigator(s): Michiyo Tsuru
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2011       Investigator(s): Kensei Nagata, Michiyo Tsuru
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research(B)
Project Year: Apr 2004 - Mar 2009    Investigator(s): Kensei Nagata
MEXT: Human resorces emerging field resource developments
Project Year: Jun 2003 - Mar 2009    Investigator(s): Michiyo Tsuru(President Minoru Hirano )
https://researchmap.jp/mutlwe1hk-1907679/#_1907679
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2009       Investigator(s): Kensei Nagata, Michiyo Tsuru
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2005       Investigator(s): Kensei Nagata, Michiyo Tsuru
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2003       Investigator(s): Kensei Nagata, Michiyo Tsuru
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2002       Investigator(s): Kensei Nagata, Michiyo Tsuru
Strut Allograft Healing to the Femur with recombinant Human OP-1.
stryker: collaboration
Project Year: 2002   
Ezaki Glico Company: collaboration
Project Year: 2002   
Health Labour Sciences Research Grant: Research on Measures for Intractable Diseases
Project Year: 2001       Investigator(s): Kensei Nagata, Michiyo Tsuru

Social Contribution

 
[Media coverage cooperation]  (YouYube)  Mar 2013

Others

 
2018   MGI;http://www.informatics.jax.org/reference/j:262080  
MGI;http://www.informatics.jax.org/reference/j:262080  
May 2018   Protocol
https://www.protocols.io/researchers/michiyo-tsuru
Oct 2018   Significance of proteomics of unknown disease