Dec, 2020
Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions.
Clinical and experimental nephrology
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- Volume
- 24
- Number
- 12
- First page
- 1122
- Last page
- 1131
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1007/s10157-020-01961-1
BACKGROUND: IgA nephropathy (IgAN) is one of the most frequently occurring types of chronic glomerulonephritis. Previous analyses have revealed that a major pathogen of dental caries, Streptococcus mutans [which expresses collagen-binding protein (Cnm) on its surface], is involved in the pathogenesis of IgAN. METHODS: Cnm-positive S. mutans isolated from a patient with IgAN was intravenously administered to specific pathogen-free Sprague-Dawley rats to evaluate their kidney conditions. RESULTS: The urinary protein level of the S. mutans group reached a plateau at 30 days, with increased numbers of mesangial cells and an increased mesangial matrix. The numbers of rats with IgA-positive and/or C3-positive glomeruli were significantly greater in the S. mutans group than in the control group at 45 days (P < 0.05). Electron microscopy analyses revealed electron-dense depositions in the mesangial area among rats in the S. mutans group. There were significantly more CD68-positive cells (macrophages) in the glomeruli of the S. mutans group than in the glomeruli of the control group during the late phase (P < 0.05), similar to the findings in patients with IgAN. CONCLUSION: Our results suggested that intravenous administration of Cnm-positive S. mutans caused transient induction of IgAN-like lesions in rats.
- Link information
- ID information
-
- DOI : 10.1007/s10157-020-01961-1
- Pubmed ID : 32909181
- Pubmed Central ID : PMC7599197