論文

査読有り
2020年2月

Hydrogen water alleviates obliterative airway disease in mice.

General thoracic and cardiovascular surgery
  • Naoki Ozeki
  • ,
  • Aika Yamawaki-Ogata
  • ,
  • Yuji Narita
  • ,
  • Shinji Mii
  • ,
  • Kaori Ushida
  • ,
  • Mikako Ito
  • ,
  • Shin-Ichi Hirano
  • ,
  • Ryosuke Kurokawa
  • ,
  • Kinji Ohno
  • ,
  • Akihiko Usui

68
2
開始ページ
158
終了ページ
163
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11748-019-01195-3

OBJECTIVE: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function in a heterotopic tracheal allograft mouse model of obliterative airway disease METHODS: Obliterative airway disease was induced by heterotopically transplanting tracheal allografts from BALB/c donor mice into C57BL/6 recipient mice, which were subsequently administered hydrogen water (10 ppm) or tap water (control group) (n = 6 each) daily without any immunosuppressive treatment. Histological and immunohistochemical analyses were performed on days 7, 14, and 21. RESULTS: Hydrogen water decreased airway occlusion on day 14. No significant histological differences were observed on days 7 or 21. The cluster of differentiation 4/cluster of differentiation 3 ratio in tracheal allografts on day 14 was higher in the hydrogen water group than in control mice. Enzyme-linked immunosorbent assay performed on day 7 revealed that hydrogen water reduced the level of the pro-inflammatory cytokine interleukin-6 and increased that of forkhead box P3 transcription factor, suggesting an enhancement of regulatory T cell activity. CONCLUSIONS: Hydrogen water suppressed the development of mid-term obliterative airway disease in a mouse tracheal allograft model via anti-oxidant and -inflammatory mechanisms and through the activation of Tregs. Thus, hydrogen water is a potential treatment strategy for BOS that can improve the outcome of lung transplant patients.

リンク情報
DOI
https://doi.org/10.1007/s11748-019-01195-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31468277
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85072032467&partnerID=MN8TOARS
ID情報
  • DOI : 10.1007/s11748-019-01195-3
  • ISSN : 1863-6705
  • ORCIDのPut Code : 120588479
  • PubMed ID : 31468277
  • SCOPUS ID : 85072032467

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