Mika Okamoto

Profile Information

Affiliation: Kagoshima University

Degree: (BLANK)(Kagoshima University)

J-GLOBAL ID: 200901066272091071
researchmap Member ID: 1000361767

External link: http://www.kufm.kagoshima-u.ac.jp/~ccvd/retro/retro.htm

Research Interests

Research Areas

Life sciences / Virology /

Research History

2002 - 2002

英国医学研究評議会（MRC）分子生物学研究所
2002 - 2002

Guest Researcher, Laboratory of Molecular
2001 - 2002

Faculty of Medicine, Kagoshima University
2001 - 2002

Research Associate, Faculty of Medicine
2000 - 2001

ルーバンカトリック大学ポストドクトラルフェロー
2000 - 2001

Postdoctoral, Katholieke Universiteit Leuven
1997 - 2000

Kagoshima University
1997 - 2000

Post doctoral Fellow, Kagoshima University
客員研究員
Biology Medical Research Council
Kagoshima University
Fellow

Education

- 1997

Kagoshima University
- 1997

Graduate School, Division of Medicine, Kagoshima University
- 1993

School of Medicine, School of Medicine, Fukushima Medical University
- 1993

Faculty of Medicine, Fukushima Medical University

Awards

2005

ECC山口メモリアルエイズ研究奨励賞

Papers

Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity.

Taiki Homma, Mika Okamoto, Ryohto Koharazawa, Mayu Hayakawa, Taiki Fushimi, Chisato Tode, Yoshihisa Hirota, Naomi Osakabe, Masanori Baba, Yoshitomo Suhara

ACS omega, 8(45) 42248-42263, Nov 14, 2023 Peer-reviewed
抗SARS-CoV-2活性を有するビタミンK誘導体の創製

小原沢諒人, 岡本実佳, 本間大暉, 早川真由, 廣田佳久, 馬場昌範, 須原義智

ビタミン, 97(4) 228-228, Apr, 2023
Amodiaquine derivatives as inhibitors of severe fever with thrombocytopenia syndrome virus (SFTSV) replication.

Masanori Baba, Mika Okamoto, Masaaki Toyama, Norikazu Sakakibara, Masayuki Shimojima, Masayuki Saijo, Takuro Niwa, Yoshiki Yagi

Antiviral research, 210 105479-105479, Feb, 2023
Novel RT-PCR Using Sugar Chain-Immobilized Gold-Nanoparticles Correlates Patients’ Symptoms: The Follow-Up Study of COVID-19 Hospitalized Patients

Takashi Kajiya, Hayate Sawayama, Eriko Arima, Mika Okamoto, Masanori Baba, Masaaki Toyama, Kosuke Okuya, Makoto Ozawa, Nobuhiko Atsuchi, Junichiro Nishi …

Viruses, 14(11) 2577-2577, Nov 21, 2022
Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

Masaaki Toyama, Koichi Watashi, Masanori Ikeda, Atsuya Yamashita, Mika Okamoto, Kohji Moriishi, Masamichi Muramatsu, Takaji Wakita, Ashoke Sharon, Masanori Baba

Antimicrobial Agents and Chemotherapy, May 23, 2022
抗ウイルス活性を有する新規ビタミン誘導体の研究

本間大暉, 岡本実佳, 馬場昌範, 須原義智

ビタミン, 96(4) 189-189, Apr, 2022
The chemokine receptor antagonist cenicriviroc inhibits the replication of SARS-CoV-2 in vitro

Mika Okamoto, Masaaki Toyama, Masanori Baba

Antiviral Research, 182, Oct, 2020 Peer-reviewed
Induction of E. coli-derived endonuclease MazF suppresses HIV-1 production and causes apoptosis in latently infected cells

Mika Okamoto, Hideto Chono, Akemi Hidaka, Masaaki Toyama, Junichi Mineno, Masanori Baba

Biochemical and Biophysical Research Communications, 530(3) 597-602, Sep 24, 2020 Peer-reviewed
Novel anti-CD70 antibody drug conjugate for the treatment of adult T-cell leukemia (ATL)

Riri Yokota, Shun Hashimoto, Ikuko Watanabe, Satoshi Kishimoto, Masaaki Toyama, Mika Okamoto, Makoto Yoshimitsu, Kenji Ishitsuka, Yuji Ito, Masanori Baba

Anticancer Research, 40(8) 4471-4479, Aug, 2020 Peer-reviewed
Successful treatment of an AIDS patient with prolonged Mycobacterium avium bacteremia, high HIV RNA, HBV infection, Kaposi's sarcoma and cytomegalovirus retinitis

Yoshitaka Furukawa, Heiichiro Hamada, Kazuto Kamikawaji, Taiji Unoki, Hiromasa Inoue, Yukie Tashiro, Mika Okamoto, Masanori Baba, Teruto Hashiguchi

Journal of Infection and Chemotherapy, 26(2) 279-281, Feb, 2020 Peer-reviewed
Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly

Masaaki Toyama, Norikazu Sakakibara, Midori Takeda, Mika Okamoto, Koichi Watashi, Takaji Wakita, Masaya Sugiyama, Masashi Mizokami, Masanori Ikeda, Masanori Baba

Virus Research, 271, Oct 2, 2019 Peer-reviewed
Galectin-3 is involved in HIV-1 expression through NF-κB activation and associated with Tat in latently infected cells

Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Masanori Baba

Virus Research, 260 86-93, Jan 15, 2019 Peer-reviewed
Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors

Masanori Baba, Masaaki Toyama, Norikazu Sakakibara, Mika Okamoto, Naomichi Arima, Masayuki Saijo

Antiviral Chemistry and Chemotherapy, 25(3) 83-89, Dec 1, 2017 Peer-reviewed
Selective inhibition of hepatitis c virus replication by alpha-zam, a nigella sativa seed formulation

Olufunmilayo G. Oyero, Masaaki Toyama, Naoki Mitsuhiro, Abdulfatah A. Onifade, Akemi Hidaka, Mika Okamoto, Masanori Baba

African Journal of Traditional, Complementary and Alternative Medicines, 13(6) 144-148, 2016 Peer-reviewed
Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative

Wataru Ito, Masaaki Toyama, Mika Okamoto, Masanori Ikeda, Koichi Watashi, Takaji Wakita, Yuichi Hashimoto, Masanori Baba

Antiviral Chemistry and Chemotherapy, 24(5-6) 148-154, Dec 1, 2015 Peer-reviewed
Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039

Mika Okamoto, Akemi Hidaka, Masaaki Toyama, Takamitsu Hosoya, Makoto Yamamoto, Masatoshi Hagiwara, Masanori Baba

Antiviral Research, 123 1-4, Nov 27, 2015 Peer-reviewed
Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives

Norikazu Sakakibara, Masanori Baba, Mika Okamoto, Masaaki Toyama, Yosuke Demizu, Takashi Misawa, Masaaki Kurihara, Kohji Irie, Yoshihisa Kato, Tokumi Maruyama

Antiviral chemistry & chemotherapy, 24(1) 3-18, Feb 1, 2015 Peer-reviewed
Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives

Norikazu Sakakibara, Gianfranco Balboni, Cenzo Congiu, Valentina Onnis, Yosuke Demizu, Takashi Misawa, Masaaki Kurihara, Yoshihisa Kato, Tokumi Maruyama, Masaaki Toyama …

Antiviral Chemistry and Chemotherapy, 24(2) 62-71, Jan 1, 2015 Peer-reviewed
A novel tetramethylnaphthalene derivative selectively inhibits adult T-Cell leukemia (ATL) cells in vitro

Masaaki Toyama, Hiroshi Aoyama, Risa Mukai, Masaharu Nakamura, Koji Yoshimura, Mika Okamoto, Takayuki Ohshima, Yuichi Hashimoto, Masanori Baba

Anticancer Research, 34(4) 1771-1778, Apr, 2014 Peer-reviewed
Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4⁺ T cells

Mika Okamoto, Hideto Chono, Yasuhiro Kawano, Naoki Saito, Hiroshi Tsuda, Koichi Inoue, Ikunoshin Kato, Junichi Mineno, Masanori Baba

Human Gene Therapy Methods, 24(2) 94-103, Apr, 2013 Peer-reviewed

Misc.

抗SARS-CoV-2活性を有する新規ビタミン誘導体の探索

本間大暉, 岡本実佳, 馬場昌範, 須原義智

日本薬学会関東支部大会講演要旨集, 66th (CD-ROM), 2022
3,5‐ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV‐1活性評価

SAKAKIBARA NORIKAZU, BABA MASANORI, OKAMOTO MIKA, SOTOYAMA MASAAKI, DEMIZU YOSUKE, MISAWA TAKASHI, KURIHARA MASAAKI, IRIE KOJI, KATO YOSHIHISA, MARUYAMA TOKUMI

日本薬学会年会要旨集(CD-ROM), 135th(2) ROMBUNNO.27PB-PM277-241, Mar, 2015
Anti-HIV-1 Gene Therapy: In Vitro Safety and Efficacy of Human CD4(+) T Cells Modified with a Gamma-Retrovirus Vector Conditionally Expressing the Bacterial Endoribonuclease MazF

Hideto Chono, Mika Okamoto, Koichi Inoue, Katsuyuki Dodo, Hiroshi Tsuda, Naoki Saito, Yasuhiro Kawano, Masanori Baba, Junichi Mineno

MOLECULAR THERAPY, 20 S177-S177, May, 2012
Super high sensitive detection of viruses using sugar-chain immobilized gold nanoparticles (SGNPs)

Xu Zang, Sachiko Nakamura Tsuruta, Mami Haruyama, Risa Yokoyama, Mami Nagatomo, Masahiro Wakao, Kazuhiko Nakajima, Kazue Aoyama, Toshiomi Okuno, Saeko Morikawa …

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243, Mar, 2012
In silico Screening of Compounds Targeting Human Cyclin T1 and In vitro Evaluation of their Anti-HIV-1 Activity

Takayuki Hamasaki, Mika Okamoto, Masanori Baba

ANTIVIRAL RESEARCH, 90(2) A33-A33, May, 2011
Long-term Inhibition of HIV-1 Replication in CD4(+) T Cells Transduced with a Retroviral Vector Conditionally Expressing the Escherichia coli Endoribonuclease MazF

Mika Okamoto, Hideto Chono, Hiroshi Tsuda, Koichi Inoue, Junichi Mineno, Masanori Baba

ANTIVIRAL RESEARCH, 90(2) A38-A38, May, 2011
Differential Expression of Host Cellular Factors upon HIV-1 Reactivation

Paula Ordonez Suarez, Takayuki Hamasaki, Masanori Baba, Mika Okamoto

ANTIVIRAL RESEARCH, 90(2) A51-A51, May, 2011
gamma-Carboline Derivatives as Potent and Selective Inhibitors of Bovine Viral Diarrhea Virus (BVDV) Replication

Masanori Baba, Mohammed Salim, Mika Okamoto, Hiroshi Aoyama, Yuichi Hashimoto, Yutaka Takebe, Jan Paeshuyse, Johan Neyts

ANTIVIRAL RESEARCH, 86(1) A29-A29, Apr, 2010 Peer-reviewed
HIV-1-infected macrophages induce astrogliosis by SDF-1α and matrix metalloproteinases

Mika Okamoto, Xin Wang, Masanori Baba

Biochemical and Biophysical Research Communications, 336(4) 1214-1220, Nov 4, 2005 Peer-reviewed
HIV-1-infected macrophages induce astrogliosis by SDF-1α and matrix metalloproteinases

Mika Okamoto, Xin Wang, Masanori Baba

Biochemical and Biophysical Research Communications, 336(4) 1214-1220, Nov 4, 2005 Peer-reviewed
Potent activation of antigen-specific T cells by antigen-loaded nanospheres

Wang, X, T Uto, K Sato, K Ide, T Akagi, M Okamoto, T Kaneko, M Akashi, M Baba

IMMUNOLOGY LETTERS, 98(1) 123-130, Apr, 2005
Potent activation of antigen-specific T cells by antigen-loaded nanospheres

Xin Wang, Tomofumi Uto, Katsuaki Sato, Keiko Ide, Takami Akagi, Mika Okamoto, Tatsuo Kaneko, Mitsuru Akashi, Masaori Baba

Immunology Letters, 98(1) 123-130, Apr, 2005 Peer-reviewed
Potent and selective inhibition of HIV-1 transcription by a novel naphthalene derivative

Wang, X, K Yamataka, M Okamoto, A Ikeda, M Baba

ANTIVIRAL RESEARCH, 65(3) A48-A48, Mar, 2005
Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein

Xin Wang, Takao Nitanda, Minyi Shi, Mika Okamoto, Tatsuhiko Furukawa, Yoshikazu Sugimoto, Shin Ichi Akiyama, Masanori Baba

Biochemical Pharmacology, 68(7) 1363-1370, Oct 1, 2004 Peer-reviewed
Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein

Xin Wang, Takao Nitanda, Minyi Shi, Mika Okamoto, Tatsuhiko Furukawa, Yoshikazu Sugimoto, Shin Ichi Akiyama, Masanori Baba

Biochemical Pharmacology, 68(7) 1363-1370, Oct 1, 2004 Peer-reviewed
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof

Mika Okamoto, Xin Wang, Zeger Debyser, Erik De Clercq, Masanori Baba

Journal of Virological Methods, 108(2) 195-203, Mar, 2003 Peer-reviewed
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof

M Okamoto, Wang, X, Z Debyser, E De Clercq, M Baba

JOURNAL OF VIROLOGICAL METHODS, 108(2) 195-203, Mar, 2003
Induction of cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors by breast cancer resistance protein (BCRP)

Wang, X, T Furukawa, T Nitanda, M Okamoto, Y Sugimoto, S Akiyama, M Baba

ANTIVIRAL RESEARCH, 57(3) A51-A51, Feb, 2003
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors

Xin Wang, Tatsuhiko Furukawa, Takao Nitanda, Mika Okamoto, Yoshikazu Sugimoto, Shin Ichi Akiyama, Masanori Baba

Molecular Pharmacology, 63(1) 65-72, Jan 1, 2003 Peer-reviewed
Inhibition of the Tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinolone derivative K-37

Wang, X, H Miyake, M Okamoto, M Saito, JI Fujisawa, Y Tanaka, S Izumo, M Baba

MOLECULAR PHARMACOLOGY, 61(6) 1359-1365, Jun, 2002

Books and Other Publications

Capture of HIV-1 gp120 and virions by lectin-immobilized polystyrene nanospheres.

Biomaterials and Drug Delivery Toward New Millenium, 2000

Professional Memberships

Research Projects

エイズ根治療法を目指したHIV-1慢性感染細胞を選択的に殺傷する薬剤の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2017 - Mar, 2020

岡本実佳, 古川良尚, 馬場昌範, 橋口照人, 外山政明
Investigation of the molecular targets for regulation of HIV-1 expression in latently infected cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

BABA Masanori, OKAMOTO Mika
HTLV-I感染特異的神経障害機構に基づくHTLV-I関連脊髄症発症機構の解明

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2004 - 2006

岡本実佳
HTLV-(]G0001[)感染症の病態および化学療法に関する研究

科学研究費補助金, 2001 - 2006
エイズ脳症の病態および化学療法に関する研究

科学研究費補助金, 2000 - 2006
ウイルス増殖にかかわる宿主細胞因子

特殊法人等における新たな基礎研究推進制度, 2002 - 2005
Host cellular factors involved in viral replication

New Program for the Promotion of Basic Reseach by Public Corporation, 2002 - 2005
Study on the pathogenesis and chemotherapy of HTLV-(]G0001[) infection

Grant-in-Aid for Scientific Research, 2001 - 2005
Study on the pathogenesis and chemotherapy of HIV-1-associated dementia

Grant-in-Aid for Scientific Research, 2000 - 2005

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

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Professional Memberships

Research Projects

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