Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry
Crotti L, Spazzolini C, Tester DJ, Ghidoni A, Baruteau AE, Beckmann BM, Behr ER, Bennett JS, Bezzina CR, Bhuiyan ZA, Celiker A, Cerrone M, Dagradi F, De Ferrari GM, Etheridge SP, Fatah M, Garcia-Pavia P, Al-Ghamdi S, Hamilton RM, Al-Hassnan ZN, Horie M, Jimenez-Jaimez J, Kanter RJ, Kaski JP, Kotta MC, Lahrouchi N, Makita N, Norrish G, Odland HH, Ohno S, Papagiannis J, Parati G, Sekarski N, Tveten K, Vatta M, Webster G, Wilde AAM, Wojciak J, George AL, Ackerman MJ, Schwartz PJ.
Eur Heart J. in press Jun 2019 [Refereed]
Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients
Shimizu, W. Makimoto, H. Yamagata, K. Kamakura, T. Wada, M. Miyamoto, K. Inoue-Yamada, Y. Okamura, H. Ishibashi, K. Noda, T. Nagase, S. Miyazaki, A. Sakaguchi, H. Shiraishi, I. Makiyama, T. Ohno, S. Itoh, H. Watanabe, H. Hayashi, K. Yamagishi, M. Morita, H. Yoshinaga, M. Aizawa, Y. Kusano, K. Miyamoto, Y. Kamakura, S. Yasuda, S. Ogawa, H. Tanaka, T. Sumitomo, N. Hagiwara, N. Fukuda, K. Ogawa, S. Aizawa, Y. Makita, N. Ohe, T. Horie, M. Aiba, T.
Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S, Makita N, Shimizu W, Horie M, Kusano K
Circulation journal 82(11) 2707-2714 Aug 2018 [Refereed]
Nakano Y, Ochi H, Sairaku A, Onohara Y, Tokuyama T, Motoda C, Matsumura H, Tomomori S, Amioka M, Hironobe N, Ohkubo Y, Okamura S, Makita N, Yoshida Y, Chayama K, Kihara Y
Circulation. Genomic and precision medicine 11(7) e001980 Jul 2018 [Refereed]
Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T
Circulation. Cardiovascular genetics 10(6) e001603 Dec 2017 [Refereed]
Hu D, Li Y, Zhang J, Pfeiffer R, Gollob MH, Healey J, Harrell DT, Makita N, Abe H, Sun Y, Guo J, Zhang L, Yan G, Mah D, Walsh EP, Leopold HB, Giustetto C, Gaita F, Zienciuk-Krajka A, Mazzanti A, Priori SG, Antzelevitch C, Barajas-Martinez H
Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T
Human molecular genetics 26(9) 1670-1677 May 2017 [Refereed]
Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K
Biochemistry and biophysics reports 9 245-256 Mar 2017 [Refereed]
Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K
Nademanee K, Raju H, De Noronha S, Papadakis M, Robinson L, Rothery S, Makita N, Kowase S, Boonmee N, Vitayakritsirikul V, Ratanarapee S, Sharma S, van der Wal AC, Christiansen M, Tan HL, Wilde AA, Nogami A, Sheppard MN, Veerakul G, Behr ER
Journal of the American College of Cardiology 67(13) 1658-1659 Apr 2016 [Refereed]
Nademanee K, Raju H, de Noronha SV, Papadakis M, Robinson L, Rothery S, Makita N, Kowase S, Boonmee N, Vitayakritsirikul V, Ratanarapee S, Sharma S, van der Wal AC, Christiansen M, Tan HL, Wilde AA, Nogami A, Sheppard MN, Veerakul G, Behr ER
Journal of the American College of Cardiology 66(18) 1976-1986 Nov 2015 [Refereed]
Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N
International journal of cardiology 190 393-402 2015 [Refereed]
Maharani N, Ting YK, Cheng J, Hasegawa A, Kurata Y, Li P, Nakayama Y, Ninomiya H, Ikeda N, Morikawa K, Yamamoto K, Makita N, Yamashita T, Shirayoshi Y, Hisatome I
Circulation journal : official journal of the Japanese Circulation Society 79(12) 2659-2668 2015 [Refereed]
Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T
International journal of cardiology 172(2) 519-522 Mar 2014 [Refereed]
Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, Hayes CN, Suzuki H, Tokuyama T, Oda N, Suenari K, Uchimura-Makita Y, Kajihara K, Sairaku A, Motoda C, Fujiwara M, Watanabe Y, Yoshida Y, Ohkubo K, Watanabe I, Nogami A, Hasegawa K, Watanabe H, Endo N, Aiba T, Shimizu W, Ohno S, Horie M, Arihiro K, Tashiro S, Makita N, Kihara Y
Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A
Circulation. Arrhythmia and electrophysiology 5(6) 1098-1107 Dec 2012 [Refereed]
Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
International journal of cardiology 159(3) 238-240 Sep 2012 [Refereed]
International journal of cardiology 158(3) 441-443 Jul 2012 [Refereed]
致死性不整脈治療の新しい潮流 QT延長症候群の診断と治療
蒔田 直昌
心電図 32(2) 190-192 Jun 2012 [Invited]
先天性QT延長症候群(LQTS)は、心電図上にQT時間の延長とtorsade de pointes(TdP)と呼ばれる重症心室性不整脈を生じて、失神や突然死をきたしうる疾患で、現在までに13の遺伝子型(LQT1〜13)が報告されている。このうちLQT1、LQT2、LQT3の3つの遺伝子型の頻度が全体の75%を占めており、それぞれ原因遺伝子であるKCNQ1、KCNH2、SCN5Aの異常が報告されている。先天性LQTSでは、あらかじめ遺伝子型を知ることが、TdPの予防および治療において重要であ...
Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M
Circulation. Arrhythmia and electrophysiology 5(1) 163-172 Feb 2012 [Refereed]
Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N
Circulation. Arrhythmia and electrophysiology 4(6) 874-881 Dec 2011 [Refereed]
Makiyama T, Akao M, Tsuji K, Doi T, Ohno S, Takenaka K, Kobori A, Ninomiya T, Yoshida H, Takano M, Makita N, Yanagisawa F, Higashi Y, Takeyama Y, Kita T, Horie M
Journal of the American College of Cardiology 46(11) 2100-2106 Dec 2005 [Refereed]
Genotype-Dependent Differences in Short QT Syndrome
Makita,N.
The 11th Asia Pacific Heart Rhythm Society Scientific Session 20 Oct 2018
Atrial Conduction Defects Caused by a Connexin45 Mutation
Makita,N.
The 11th Asia Pacific Heart Rhythm Society Scientific Session 20 Oct 2018
Novel Arrhythmia Syndrome Associated with Gap Junction Mutations
Makita,N.
The 11th Asia Pacific Heart Rhythm Society Scientific Session 19 Oct 2018
Clinical and Genetic Basis of Calmodulinopathy
Makita, N.
The 11th Asia Pacific Heart Rhythm Society Scientific Session 18 Oct 2018
Pathophysiology of Inherited Arrhythmias Associated with Ca Handling Abnormality[Invited]
Makita N.
The 65th Annual Meeting of the Japan Heart Rhythm Society 14 Jul 2018
HCN4 Polymorphisms and Tachycardia Induced Cardiomyopathy
Nakano Y., Ochi H., Onohara Y., Sairaku A., Tokuyama T., Motoda C., Matsumura H., Tomomori S., Amioka M., Hironobe N., Ohkubo Y., Okamura S., Makita N., Yoshida Y., Chayama K., Kihara Y.
The 65th Annual Meeting of the Japan Heart Rhythm Society 14 Jul 2018
Rare Coding Variants in Genes Other Than SCN5A Are Minimal Genetic Burden on the Prognosis of Brugada Syndrome
Ishikawa T., Mishima H., Ohno S., T. Aiba, Nakano Y., Aizawa Y., Nakajima T., Hayashi K., Murakoshi N., Yagihara N., Kimoto H., Makiyama T., Watanabe H., Morita H., Yoshiura K., Nogami A., Shimizu W., Horie M., Tanaka T., Makita N.
The 65th Annual Meeting of the Japan Heart Rhythm Society 13 Jul 2018
Clinical Manifestations and Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry
Nakajima K., Aiba T., Makiyama T., Nishiuchi S., Ohno S., Doi T., Shizuta S., Onoue K., Yagihara N., Ishikawa T., Watanabe I., Oginosawa Y., Nogami A., Aonuma K., Saitoh Y., Kimura T., Makita N., Shimizu W., Horie M., Kusano K.
The 65th Annual Meeting of the Japan Heart Rhythm Society 13 Jul 2018
CaMKII as a target for novel therapy to treat lethal ventricular tachyarrhythmias.[Invited]
辻幸臣, 蒔田直昌
第57回日本生体医工学学会大会 21 Jun 2018
Lack Of Genotype-phenotype Correlation In Brugada Syndrome And Sudden Arrhythmic Death Syndrome Families With Reported Pathogenic SCN1B Variants
Gray B. , Hasdemir C. , Ingles J. , Aiba T., Makita N. , PROBST V. , Wilde A., Semsarian C. , Sy R., Behr E.
The 39th Heart Rhythm Society Scientific Sessions 11 May 2018
AMED: Development of High Throughput Screening Technology to Functionally Validate VUSs of Cardiac Ion Channel Genes Responsible for Hereditary Lethal Arrhythmia
Project Year: Jul 2019 - Mar 2022 Investigator(s): MAKITA Naomasa
Background:
Congenital long QT syndrome (LQTS) and Brugada syndrome (BrS) are inherited predispositions to sudden cardiac death due to lethal ventricular arrhythmia, attributable mainly to mutations in cardiac ion channel genes. As with many othe...
MEXT: 国際共同研究加速基金（国際共同研究強化（Ｂ））
Project Year: 2018 - Mar 2021 Investigator(s): MAKITA Naomasa
Eludication of Genetic Risks for Sudden Cardiac Death and Development of Risk Stratification
Japan Agency for Medical Research and Development, AMED:
Project Year: Oct 2015 - Mar 2018 Investigator(s): MAKITA Naomasa
ncvc.go.jp