論文

査読有り
2017年4月

Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine: A Nationwide Survey and Genetic Study in Japan

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
  • Keiichi Uchida
  • ,
  • Atsushi Nakajima
  • ,
  • Kosuke Ushijima
  • ,
  • Shinobu Ida
  • ,
  • Yoshitaka Seki
  • ,
  • Fumihiko Kakuta
  • ,
  • Daiki Abukawa
  • ,
  • Hisayuki Tsukahara
  • ,
  • Shun-ichi Maisawa
  • ,
  • Mikihiro Inoue
  • ,
  • Toshimitsu Araki
  • ,
  • Junji Umeno
  • ,
  • Takayuki Matsumoto
  • ,
  • Tomoaki Taguchi

64
4
開始ページ
565
終了ページ
568
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/MPG.0000000000001321
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

We performed a Japanese nationwide survey of pediatric-onset chronic nonspecific multiple ulcers of the small intestine between January 2000 and July 2013 in 176 institutions of pediatric surgery or pediatric gastroenterology and clarified the clinical features associated with genetic abnormalities in the Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) gene. A total of 4 cases (3 girls and 1 boy) were diagnosed in this series, which had to be differentiated from Crohn disease, Behcet disease, tuberculosis, or drug-induced enteropathy. Clinical symptoms appeared in infants and accurate diagnosis required several years. Medical therapies for inflammatory bowel disease were administered in all patients; however, 2 of the 4 patients had mutation in the SLCO2A1 gene which are responsible for primary hypertrophic osteoarthopathy, and underwent strictureplasty or ileal resection after long-term follow-up. Pediatric gastroenterologists should include this new entity in the differential diagnosis of small intestinal ulcers and inflammatory bowel disease.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1097/MPG.0000000000001321
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27467110
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000398215300025&DestApp=WOS_CPL

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