論文

査読有り 国際誌
2020年1月28日

Programmable RNA methylation and demethylation using PUF RNA binding proteins.

Chemical communications (Cambridge, England)
  • Kouki Shinoda
  • ,
  • Akiyo Suda
  • ,
  • Kenko Otonari
  • ,
  • Shiroh Futaki
  • ,
  • Miki Imanishi

56
9
開始ページ
1365
終了ページ
1368
記述言語
英語
掲載種別
DOI
10.1039/c9cc09298f

New methods to control local RNA methylation are needed to elucidate the function of individual m6A. Here, fusion proteins between the programmable RNA binding protein PUF and the m6A demethylase FTO or METTL14 methyltransferase were designed. FTO-PUFs and METTL14-PUFs showed sequence-specific RNA demethylation and methylation activities, respectively.

リンク情報
DOI
https://doi.org/10.1039/c9cc09298f
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31909398

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