TANABE MIKIO

Profile Information

Affiliation: 特任准教授, 物質構造科学研究所、構造生物学研究センター, 大学共同利用機関法人高エネルギー加速器研究機構

Degree: Ph.D.(Imperial College London)

J-GLOBAL ID: 201801016995893012
researchmap Member ID: B000309561

Research Interests

Research Areas

Life sciences / Structural biochemistry /

Research History

2015 - Present

High Energy Accelerator Research Organization
2009 - 2015

Martin-Luther-University Halle-Wittenberg
2006 - 2009

Department of Pharmacology, Vanderbilt University Medical Center

Education

2002 - 2006

Division of Molecular Biosciences & Division of Cell and Molecular Biology., Imperial College London
2000 - 2002

産業科学研究所, 大阪大学工学研究科応用生物学専攻 M.Eng.
1999 - 2000

School of Engineering, Osaka University

Committee Memberships

2022

Editorial Board, Frontiers in Biophysics

Awards

2013

Hugo-Junkers-Prize (ドイツ)

田辺幹雄
2006

上原記念ポストドクトラルフェローシップ

田辺幹雄

Papers

Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero.

Masayoshi Sakakura, Mikio Tanabe, Masaki Mori, Hideo Takahashi, Kazuhiro Mio

Structure (London, England : 1993), Aug 30, 2023 Peer-reviewed
Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites.

Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga

Nature chemistry, Jul 6, 2023 Peer-reviewed
Molecular Tension Probe for In Vitro Bioassays.

Sung-Bae Kim, Rika Fujii, Simon Miller, Mikio Tanabe

Methods in molecular biology (Clifton, N.J.), 2524 91-103, 2022
An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding.

Annika Bartsch, Callum M Ives, Christof Kattner, Florian Pein, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem, Salomé Llabrés

Biochimica et biophysica acta. Biomembranes, 1863(6) 183601-183601, Jun 1, 2021 Peer-reviewed
Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS).

David Drew, Rachel A North, Kumar Nagarathinam, Mikio Tanabe

Chemical reviews, 121(9) 5289-5335, May 12, 2021 Peer-reviewedInvitedLast authorCorresponding author
A fully automated crystallization apparatus for small protein quantities.

Ryuichi Kato, Masahiko Hiraki, Yusuke Yamada, Mikio Tanabe, Toshiya Senda

Acta crystallographica. Section F, Structural biology communications, 77(Pt 1) 29-36, Jan 1, 2021 Peer-reviewed
Correction to "How Does a Microbial Rodhopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?"

Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo …

The journal of physical chemistry. B, 124(14) 2973-2973, Apr 9, 2020
How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?

Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo …

The journal of physical chemistry. B, 124(6) 990-1000, Feb 13, 2020 Peer-reviewed
High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB.

Annika Bartsch, Salomé Llabrés, Florian Pein, Christof Kattner, Markus Schön, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem

Scientific reports, 9(1) 1264-1264, Feb 4, 2019 Peer-reviewed
Hyperbolic Pressure-Temperature Phase Diagram of the Zinc-Finger Protein apoKti11 Detected by NMR Spectroscopy.

Andi Klamt, Kumar Nagarathinam, Mikio Tanabe, Amit Kumar, Jochen Balbach

The journal of physical chemistry. B, 123(4) 792-801, Jan 31, 2019 Peer-reviewed
Outward open conformation of a Major Facilitator Superfamily multidrug/H⁺ antiporter provides insights into switching mechanism.

Nagarathinam K, Nakada-Nakura Y, Parthier C, Terada T, Juge N, Jaenecke F, Liu K, Hotta Y, Miyaji T, Omote H …

Nature communications, 9(1) 4005-4005, Oct, 2018 Peer-reviewedLast authorCorresponding author
Generation of Conformation-Specific Antibody Fragments for Crystallization of the Multidrug Resistance Transporter MdfA

Frank Jaenecke, Yoshiko Nakada-Nakura, Kumar Nagarathinam, Satoshi Ogasawara, Kehong Liu, Yunhon Hotta, So Iwata, Norimichi Nomura, Mikio Tanabe

Methods in Molecular Biology, 1700 97-109, 2018 Peer-reviewedLast authorCorresponding author
The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis

Kumar Nagarathinam, Frank Jaenecke, Yoshiko Nakada-Nakura, Yunhon Hotta, Kehong Liu, So Iwata, Milton T. Stubbs, Norimichi Nomura, Mikio Tanabe

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 73(Pt 7) 423-430, Jul, 2017 Peer-reviewedLast authorCorresponding author
Structural and biological approaches to understand the drug transport mechanisms of the multidrug resistance transporter MdfA

Tanabe Mikio

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S50, Mar, 2017
Typing and Surface Charges of the Variable Loop Regions of PorB from Neisseria meningitidis

Paola Stefanelli, Arianna Neri, Mikio Tanabe, Cecilia Fazio, Paola Massari

IUBMB LIFE, 68(6) 488-495, Jun, 2016 Peer-reviewed
Structural analyses of MFS-type multidrug resistance transporters using the research framework of PDIS

Tanabe Mikio

JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3) S111, Mar, 2016
One-Step Purification and Porin Transport Activity of the Major Outer Membrane Proteins P2 from Haemophilus influenzae, FomA from Fusobacterium nucleatum and PorB from Neisseria meningitidis

Christof Kattner, Sabrina Pfennig, Paola Massari, Mikio Tanabe

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 175(6) 2907-2915, Mar, 2015 Peer-reviewedLast authorCorresponding author
Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition

Christof Kattner, Deana N. Toussi, Jan Zaucha, Lee M. Wetzler, Nadine Rueppel, Ulrich Zachariae, Paola Massari, Mikio Tanabe

JOURNAL OF STRUCTURAL BIOLOGY, 185(3) 440-447, Mar, 2014 Peer-reviewedLast authorCorresponding author
Dual-Color Fluorescence Cross-Correlation Spectroscopy of Reconstituted Protein-Membrane Systems

Daniela Kruger, Stefan Werner, Sebastian Daum, Jan Auerswald, Peter Simeonov, Caroline Haupt, Mikio Tanabe, Kirsten Bacia

BIOPHYSICAL JOURNAL, 106(2) 712A-712A, Jan, 2014 Peer-reviewed
Membrane protein reconstitution into liposomes guided by dual-color fluorescence cross-correlation spectroscopy

Peter Simeonov, Stefan Werner, Caroline Haupt, Mikio Tanabe, Kirsten Bacia

BIOPHYSICAL CHEMISTRY, 184 37-43, Dec, 2013 Peer-reviewed

Misc.

De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function

Takahiro Kosugi, Tatsuya Iida, Mikio Tanabe, Ryota Iino, Nobuyasu Koga

BioRxiv, Sep 9, 2020
MFS型多剤排出トランスポーターMdfAの薬剤輸送に伴う構造変化のメカニズム

56(6) 509-513, Jun, 2020 InvitedLead authorLast authorCorresponding author

Presentations

Structural and molecular dynamical approaches to understand mysterious mechanistic aspects of a H+/multidrug transporter

HALOmem International Meeting - Membrane Protein & Dynamics -, Nov, 2019 Invited
Structural and Molecular Dynamical Approaches to understand MFS-type Multidrug Resistance Transporters

Gordon Research Conference - Multidrug efflux systems, May, 2019 Invited
Structural biology research center in KEK/high energy accelerator research organization

Protein Structure determination in Industry (PSDI) 2018., Nov, 2018
多剤排出トランスポーターの薬剤物質排出メカニズム解明に向けての構造生学的アプローチ

田辺幹雄

第90回日本薬理学会年会, Mar, 2017
MFS型多剤排出トランスポーターMdfAの薬剤物質排出に伴う構造変化の解明

田辺幹雄

第90回日本細菌学会総会, Mar, 2017
Structural Insights into the Conformational Switching Mechanism of a Secondary Multidrug/Proton Antiporter

田辺幹雄

Gordon Research Conference, Multi-drug efflux systems, Mar, 2017 Invited
MFS型多剤排出トランスポーターの構造学的解析と創薬等支援技術基盤プラットフォームの仕組みを利用した研究の推進

田辺幹雄

第89回日本薬理学会年会, Mar, 2016

Teaching Experience

Professional Memberships

Research Projects

Structural analyses of PMP22 and MPZ to elucidate the molecular mechanism of Charcot-Marie-Tooth disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
MFS型多剤排出輸送体の多剤認識と輸送機構の解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2023

田辺幹雄, 野村紀通, 樹下成信
MAドメインとカルジオリピンとの結合を基軸とした抗エイズ薬の創製

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

安楽健作, 湯本史明, 坂本亜里紗, 田辺幹雄
Creation of a multicolor bioluminescence platform for assaying bioactive small molecules

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Kim Sung Bae
Investigation of outer membrane protein recognition mechniams by human pathgen recognition receptors

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Tanabe Mikio, STEINAM Claudia, Ulrich Zachariae, Bahrmann Elmar, Paola Massari, Paola Stefanelli

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

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Professional Memberships

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