2008年11月
Role of alpha(v) integrin in osteoprotegerin-induced endothelial cell migration and proliferation
MICROVASCULAR RESEARCH
- ,
- ,
- ,
- 巻
- 76
- 号
- 3
- 開始ページ
- 139
- 終了ページ
- 144
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.mvr.2008.06.004
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Osteoprotegerin (OPG) is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). However, the role of OPG in the endothelium remains unknown. In this study, we demonstrate that OPG stimulates the proliferation and migration of human microvascular endothelial cells (HMVECs). In addition, we show that treatment with integrin alpha(v)beta(3) or integrin alpha(v)beta(5) blocking antibody inhibits endothelial cell migration. In contrast, treatment with anti-alpha(v)beta(3) antibody or anti-alpha(v)beta(5) antibody alone did not inhibit OPG-induced proliferation. However, OPG-induced proliferation was inhibited when these antibodies were applied simultaneously. Furthermore, OPG evoked activation of extracellular signal-regulated kinase (ERK) 1/2, which has been linked to integrin alpha(v) activity. Taken together, these results suggest that integrins alpha(v)beta(3) and/or alpha(v)beta(5) contribute to endothelial cell proliferation and migration induced by OPG. (C) 2008 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.mvr.2008.06.004
- ISSN : 0026-2862
- PubMed ID : 18656492
- Web of Science ID : WOS:000260607700001