2020年4月
Experimental Animal Model of Re-irradiation to Evaluate Radiation-induced Damage in the Normal Intestine.
Anticancer research
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- 巻
- 40
- 号
- 4
- 開始ページ
- 1981
- 終了ページ
- 1988
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.21873/anticanres.14153
BACKGROUND/AIM: We aimed to elucidate the pathological findings following acute and late re-irradiation in a preclinical model. MATERIALS AND METHODS: Mice were divided into five treatment groups: sham-irradiation (Sham-IR), 10-12 Gy (Single IR Acute), 15 Gy (Single IR Late), 15 Gy followed by 10-12 Gy re-irradiation 7 days later (Re-IR Acute), or 15 Gy followed by 10-12 Gy re-irradiation 12 weeks later (Re-IR Late). Mice were sacrificed after either single irradiation or re-irradiation for pathological assessment. RESULTS: The Re-IR Late group had significantly lower numbers of crypts with apoptotic cells than those observed in mice in the Single IR Acute group. There were no significant differences between the Single IR Acute and re-IR Acute groups in cell proliferation or in a crypt survival assay. CONCLUSION: Re-irradiation with a long interval after the first irradiation may cause similar acute biological effects in normal intestine as observed following irradiation without re-irradiation.
- リンク情報
- ID情報
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- DOI : 10.21873/anticanres.14153
- PubMed ID : 32234887