MINAMI Masabumi

J-GLOBAL         Last updated: Dec 11, 2019 at 19:38
 
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Name
MINAMI Masabumi
E-mail
mminamipharm.hokudai.ac.jp
URL
http://www.pharm.hokudai.ac.jp/yakuri/index.html
Affiliation
Hokkaido University
Section
Faculty of Pharmaceutical Sciences
Job title
Professor
Degree
Doctor of Pharmaceutical Science(Kyoto University), Master of Pharmaceutical Science(Kyoto University)
Research funding number
20243040
ORCID ID
0000-0002-0144-0679

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Kyoto University, Instructor
 
 
   
 
Kyoto University, Associate professor
 
1992
 - 
1997
Faculty of Pharmaceutical Sciences
 
1997
   
 
- Graduate School of Pharmaceutical Sciences
 

Education

 
 
 - 
1992
Graduate School, Division of Pharmaceutical Sciences, Kyoto University
 
 
 - 
1987
Faculty of Pharmaceutical Science, Kyoto University
 

Awards & Honors

 
2001
The Pharmaceutical Society of Japan Award for Young Scientists
 

Published Papers

 
Tonic suppression of the mesolimbic dopaminergic system by enhanced corticotropin-releasing factor signaling within the bed nucleus of the stria terminalis in chronic pain model rats.
Daiki Takahashi, Yuta Asaoka, Keisuke Kimura, Ryuto Hara, Saya Arakaki, Keisuke Sakasai, Hiroe Suzuki, Naoki Yamauchi, Hiroshi Nomura, Taiju Amano and Masabumi Minami
The Journal of Neuroscience   39(42) 8376-8385   Oct 2019   [Refereed]
Effect of gonadal steroid hormone levels during pubertal development on social behavior of adult mice toward pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis.
Kiyoshiro Fukui, Haruka Uki, Masabumi Minami, Taiju Amano
Neuroscience Letters   708 134357   Aug 2019   [Refereed]
Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.
Hiroshi Nomura, Hiroto Mizuta, Hiroaki Norimoto, Fumitaka Masuda, Yuki Miura, Ayame Kubo, Hiroto Kojima, Aoi Ashizuka, Noriko Matsukawa, Zoha lBaraki, Natsuko Hitora-Imamura, Daisuke Nakayama, Tomoe Ishikawa, et al.
Biological Psychiatry   86(3) 230-239   Aug 2019   [Refereed]
Minami S, Nomura H, Minami M
Neuropsychopharmacology reports      Oct 2018   [Refereed]
Ide S, Yamamoto R, Suzuki H, Takeda H, Minami M
Neuropsychopharmacology reports      Sep 2018   [Refereed]
Hinata M, Imai S, Sanaki T, Tsuchida J, Yoshioka T, Higashino K, Yamamoto M, Imai M, Soga M, Horita N, Fukuda I, Ikeda M, Yamane S, Morita A, Kanemasa T, Sakaguchi G, Hasegawa M, Minami M, Morioka Y
Pain   159(5) 939-947   May 2018   [Refereed]
Ide S, Yamamoto R, Takeda H, Minami M
Neuropsychopharmacology reports   38(1) 37-43   Mar 2018   [Refereed]
Shinohara F, Asaoka Y, Kamii H, Minami M, Kaneda K
Addiction biology      Feb 2018   [Refereed]
Yamauchi Naoki, Takahashi Daiki, Sugimura Yae K, Kato Fusao, Amano Taiju, Minami Masabumi
European Journal of Neuroscience   48(9) 3052-3061   2018   [Refereed]
Tachikawa Masanori, Yashiki Ayane, Akanuma Shin-ichi, Matsukawa Haruka, Ide Soichiro, Minami Masabumi, Hosoya Ken-ichi
Neurochemistry International   113 1-7   2018   [Refereed]
Suemasa Akihiro, Watanabe Mizuki, Kobayashi Takaaki, Suzuki Hiroe, Fukuda Hayato, Minami Masabumi, Shuto Satoshi
Bioorganic & Medicinal Chemistry Letters   28(20) 3395-3399   2018   [Refereed]
Asaoka Yuta, Kato Takahiro, Ide Soichiro, Amano Taiju, Minami Masabumi
Neuroscience Letters   668 133-137   2018   [Refereed]
Deyama Satoshi, Shimoda Kento, Suzuki Hiroe, Ishikawa Yuka, Ishimura Kohei, Fukuda Hayato, Hitora-Imamura Natsuko, Ide Soichiro, Satoh Masamichi, Kaneda Katsuyuki, Shuto Satoshi, Minami Masabumi
Psychopharmacology   235(1) 329-336   2018   [Refereed]
Deyama Satoshi, Shimoda Kento, Ikeda Hiroyuki, Fukuda Hayato, Shuto Satoshi, Minami Masabumi
Journal of Pharmacological Sciences   138(1) 86-88   2018   [Refereed]
Maruyama Chikashi, Deyama Satoshi, Nagano Yusuke, Ide Soichiro, Kaneda Katsuyuki, Yoshioka Mitsuhiro, Minami Masabumi
European Journal of Neuroscience   47(1) 40-47   2018   [Refereed]
Deyama Satoshi, Sugano Yaya, Mori Sakura, Amano Taiju, Yoshioka Mitsuhiro, Kaneda Katsuyuki, Minami Masabumi
Neuropharmacology   118 59-68   2017   [Refereed]
Amano Taiju, Shindo Sayaka, Yoshihara Chihiro, Tsuneoka Yousuke, Uki Haruka, Minami Masabumi, Kuroda Kumi O.
Behavioural Brain Research   325 131-137   2017   [Refereed]
Kamii Hironori, Taoka Naofumi, Minami Masabumi, Kaneda Katsuyuki
Neuroscience Letters   660 39-44   2017   [Refereed]
Ishikawa Yuka, Deyama Satoshi, Shimoda Kento, Yoshikawa Kotomi, Ide Soichiro, Satoh Masamichi, Minami Masabumi
Behavioural Brain Research   332 233-236   2017   [Refereed]
Deyama Satoshi, Ishikawa Yuka, Yoshikawa Kotomi, Shimoda Kento, Ide Soichiro, Satoh Masamichi, Minami Masabumi
International Journal of Neuropsychopharmacology   20(7) 575-584   2017   [Refereed]
Minami Saki, Satoyoshi Hiroshi, Ide Soichiro, Inoue Takeshi, Yoshioka Mitsuhiro, Minami Masabumi
Neuroscience Letters   650 72-76   2017   [Refereed]
Shinohara Fumiya, Kamii Hironori, Minami Masabumi, Kaneda Katsuyuki
Biological & Pharmaceutical Bulletin   40(11) 1983-1989   2017   [Refereed]
Kaneko Tomoyuki, Kaneda Katsuyuki, Ohno Atsushi, Takahashi Daiki, Hara Taiki, Amano Taiju, Ide Soichiro, Yoshioka Mitsuhiro, Minami Masabumi
European Journal of Neuroscience   44(11) 2914-2924   2016   [Refereed]
Oguma Takahiro, Kuriyama Chiaki, Nakayama Keiko, Matsushita Yasuaki, Hikida Kumiko, Tsuda-Tsukimoto Minoru, Saito Akira, Arakawa Kenji, Ueta Kiichiro, Minami Masabumi, Shiotani Masaharu
Journal of Pharmacological Sciences   132(4) 255-261   2016   [Refereed]
Taoka Naofumi, Kamiizawa Ryota, Wada Shintaro, Minami Masabumi, Kaneda Katsuyuki
European Journal of Neuroscience   44(12) 3035-3045   2016   [Refereed]
Kato Takahiro, Ide Soichiro, Minami Masabumi
Neuroscience Letters   629 73-78   2016   [Refereed]
Ohmura Yu, Yoshida Takayuki, Konno Kohtarou, Minami Masabumi, Watanabe Masahiko, Yoshioka Mitsuhiro
International Journal of Neuropsychopharmacology   19(6)    2016   [Refereed]
Ide Soichiro, Satoyoshi Hiroshi, Minami Masabumi, Satoh Masamichi
Molecular Pain   11    2015   [Refereed]
Nagano Yusuke, Kaneda Katsuyuki, Maruyama Chikashi, Ide Soichiro, Kato Fusao, Minami Masabumi
Neuroscience Letters   600 56-61   2015   [Refereed]
Minami M, Ide S.
Current Molecular Medicine   15(2) 184-190   2015   [Refereed]
Kamii Hironori, Kurosawa Ryo, Taoka Naofumi, Shinohara Fumiya, Minami Masabumi, Kaneda Katsuyuki
European Journal of Neuroscience   41(9) 1126-1138   2015   [Refereed]
Kobayashi Takaaki, Suemasa Akihiro, Igawa Arisa, Ide Soichiro, Fukuda Hayato, Abe Hiroshi, Arisawa Mitsuhiro, Minami Masabumi, Shuto Satoshi
Acs Medicinal Chemistry Letters   5(8) 889-893   2014   [Refereed]
Shinohara Fumiya, Kihara Yukari, Ide Soichiro, Minami Masabumi, Kaneda Katsuyuki
Neuropharmacology   79 573-579   2014   [Refereed]
Kudo Takehiro, Konno Kohtarou, Uchigashima Motokazu, Yanagawa Yuchio, Sora Ichiro, Minami Masabumi, Watanabe Masahiko
European Journal of Neuroscience   39(11) 1796-1809   2014   [Refereed]
Ide Soichiro, Nishizawa Daisuke, Fukuda Ken-ichi, Kasai Shinya, Hasegawa Junko, Hayashida Masakazu, Minami Masabumi, Ikeda Kazutaka
Molecular Pain   10    2014   [Refereed]
Hatae Noriyuki, Nagayama Tomoyuki, Esaki Hiroyoshi, Kujime Eiko, Minami Masabumi, Ishikura Minoru, Choshi Tominari, Hibino Satoshi, Okada Chiaki, Toyota Eiko, Nagasawa Hideko, Iwamura Tatsunori
Heterocycles   88(1) 663-673   2014   [Refereed]
Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K
PloS one   8(8) e70694   2013   [Refereed]
Naka Tomonori, Ide Soichiro, Nakako Tomokazu, Hirata Mikie, Majima Yuki, Deyama Satoshi, Takeda Hiroshi, Yoshioka Mitsuhiro, Minami Masabumi
Neuropharmacology   67 326-330   2013   [Refereed]
Saito Nozomi, Nakamura Ken-ichi, Shibano Sayako, Ide Soichiro, Minami Masabumi, Sato Yoshihiro
Organic Letters   15(2) 386-389   2013   [Refereed]
Kurosawa Ryo, Taoka Naofumi, Shinohara Fumiya, Minami Masabumi, Kaneda Katsuyuki
European Journal of Neuroscience   38(7) 3027-3035   2013   [Refereed]
Nakada Kazuaki, Yoshikawa Mamie, Ide Soichiro, Suemasa Akihiro, Kawamura Shuhei, Kobayashi Takaaki, Masuda Eiji, Ito Yoshihiko, Hayakawa Wataru, Katayama Takahiro, Yamada Shizuo, Arisawa Mitsuhiro, Minami Masabumi, Shuto Satoshi
Bioorganic & Medicinal Chemistry   21(17) 4938-4950   2013   [Refereed]
Ide Soichiro, Hara Taiki, Ohno Atsushi, Tamano Ryuta, Koseki Kana, Naka Tomonori, Maruyama Chikashi, Kaneda Katsuyuki, Yoshioka Mitsuhiro, Minami Masabumi
Journal of Neuroscience   33(14) 5881-5894   2013   [Refereed]
Ohmura Yu, Kumamoto Haruko, Tsutsui-Kimura Iku, Minami Masabumi, Izumi Takeshi, Yoshida Takayuki, Yoshioka Mitsuhiro
Journal of Pharmacological Sciences   122(2) 84-92   2013   [Refereed]
Katayama Takahiro, Kobayashi Hayato, Okamura Toshiyuki, Yamasaki-Katayama Yuko, Kibayashi Tatsuya, Kimura Hiroshi, Ohsawa Keiko, Kohsaka Shinichi, Minami Masabumi
Plos One   7(7)    2012   [Refereed]
Ohmura Yu, Tsutsui-Kimura Iku, Kumamoto Haruko, Minami Masabumi, Izumi Takeshi, Yamaguchi Taku, Yoshida Takayuki, Yoshioka Mitsuhiro
Psychopharmacology   219(2) 421-432   2012   [Refereed]
Okamura Toshiyuki, Katayama Takahiro, Obinata Chihiro, Iso Yukina, Chiba Yuzuho, Kobayashi Hayato, Yamada Yuma, Harashima Hideyoshi, Minami Masabumi
Journal of Neuroscience Research   90(11) 2127-2133   2012   [Refereed]
Asano Hiroshi, Horinouchi Takahiro, Mai Yosuke, Sawada Osamu, Fujii Shunsuke, Nishiya Tadashi, Minami Masabumi, Katayama Takahiro, Iwanaga Toshihiko, Terada Koji, Miwa Soichi
Journal of Pharmacological Sciences   118(2) 275-287   2012   [Refereed]
Kudo Takehiro, Uchigashima Motokazu, Miyazaki Taisuke, Konno Kohtarou, Yamasaki Miwako, Yanagawa Yuchio, Minami Masabumi, Watanabe Masahiko
Journal of Neuroscience   32(50) 18035-18046   2012   [Refereed]
Ide Soichiro, Minami Masabumi, Uhl George R, Satoh Masamichi, Sora Ichiro, Ikeda Kazutaka
Molecular Pain   7    2011   [Refereed]
Deyama Satoshi, Ide Soichiro, Kondoh Naoto, Yamaguchi Taku, Yoshioka Mitsuhiro, Minami Masabumi
Neuropharmacology   61(1-2) 156-160   2011   [Refereed]
Matsushita Takashi, Kibayashi Tatsuya, Katayama Takahiro, Yamashita Yuuki, Suzuki Syuuichirou, Kawamata Jun, Honmou Osamu, Minami Masabumi, Shimohama Shun
Neuroscience Letters   502(1) 41-45   2011   [Refereed]
Numajiri Naoki, Takasawa Kumi, Nishiya Tadashi, Tanaka Hirotaka, Ohno Kazuki, Hayakawa Wataru, Asada Mariko, Matsuda Hiromi, Azumi Kaoru, Kamata Hideaki, Nakamura Tomohiro, Hara Hideaki, Minami Masabumi, Lipton Stuart A, Uehara Takashi
Proceedings of the National Academy of Sciences of the United States of America   108(25) 10349-10354   2011   [Refereed]
Ide Soichiro, Fujiwara Shunsuke, Fujiwara Masayuki, Sora Ichiro, Ikeda Kazutaka, Minami Masabumi, Uhl George R, Ishihara Kumatoshi
Journal of Pharmacological Sciences   114(1) 107-110   2010   [Refereed]
Ide Soichiro, Sora Ichiro, Ikeda Kazutaka, Minami Masabumi, Uhl George R, Ishihara Kumatoshi
Neuropharmacology   58(1) 241-247   2010   [Refereed]
Deyama Satoshi, Takishita Azusa, Tanimoto Sachi, Ide Soichiro, Nakagawa Takayuki, Satoh Masamichi, Minami Masabumi
Journal of Pharmacological Sciences   114(1) 123-126   2010   [Refereed]
Katayama Takahiro, Sakaguchi Emi, Komatsu Yosuke, Oguma Takahiro, Uehara Takashi, Minami Masabumi
European Journal of Neuroscience   31(8) 1359-1367   2010   [Refereed]
Minami Masabumi, Bagetta G, Corasaniti MT, Sakurada T, Sakurada S
Advances in Neuropharmacology   85 135-144   2009   [Refereed]
Katayama Takahiro, Tanaka Hiroki, Yoshida Tadashi, Uehara Takashi, Minami Masabumi
Journal of Pharmacological Sciences   109(1) 88-93   2009   [Refereed]
Katayama Takahiro, Ito Misato, Kaneko Shuji, Satoh Masamichi, Uehara Takashi, Minami Masabumi
Journal of Neuroscience Research   87(7) 1573-1581   2009   [Refereed]
Deyama Satoshi, Katayama Takahiro, Kondoh Naoto, Nakagawa Takayuki, Kaneko Shuji, Yamaguchi Taku, Yoshioka Mitsuhiro, Minami Masabumi
Behavioural Brain Research   197(2) 279-283   2009   [Refereed]
Ide Soichiro, Minami Masabumi, Ishihara Kumatoshi, Uhl George R, Satoh Masamichi, Sora Ichiro, Ikeda Kazutaka
Neuropharmacology   54(8) 1182-1188   2008   [Refereed]
Deyama Satoshi, Katayama Takahiro, Ohno Atsushi, Nakagawa Takayuki, Kaneko Shuji, Yamaguchi Taku, Yoshioka Mitsuhiro, Minami Masabumi
Journal of Neuroscience   28(31) 7728-7736   2008   [Refereed]
Nakagawa T, Wakamatsu K, Zhang N, Maeda S, Minami M, Satoh M, Kaneko S
Neuroscience   147(2) 445-455   Jun 2007   [Refereed]
Deyama Satoshi, Yamamoto Junki, Machida Taiichi, TaniMoto Sachi, Nakagawa Takayuki, Kaneko Shuji, Satoh Masamichi, Minami Masabumi
Neuroscience Research   59(2) 199-204   2007   [Refereed]
Deyama Satoshi, Nakagawa Takayuki, Kaneko Shuji, Uehara Takashi, Minami Masabumi
Behavioural Brain Research   176(2) 367-371   2007   [Refereed]
Minami M, Katayama T, Satoh M
Journal of Pharmacological Sciences   100(5) 461-470   2006   [Refereed]
Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y
Journal of Biological Chemistry   281(16) 11397-11404   2006   [Refereed]
Fukui Masato, Nakagawa Takayuki, Minami Masabumi, Satoh Masamichi, Kaneko Shuji
Molecular Pain   2    2006   [Refereed]
Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I.
Pharmacogenomics Journal   6(3) 179-188   2006   [Refereed]
Ide Soichiro, Minami Masabumi, Ishihara Kumatoshi, Uhl George R, Sora Ichiro, Ikeda Kazutaka
Neuropharmacology   51(3) 651-658   2006   [Refereed]
Nakagawa T, Fujio M, Ozawa T, Minami M, Satoh M
Behavioural brain research   156(2) 233-239   Jan 2005   [Refereed]
Fujio M, Nakagawa T, Sekiya Y, Ozawa T, Suzuki Y, Minami M, Satoh M, Kaneko S
European Journal of Neuroscience   22(11) 2744-2754   2005   [Refereed]
Nakagawa T, Yamamoto R, Fujio M, Suzuki Y, Minami M, Satoh M, Kaneko S
Neuroscience   134(1) 9-19   2005   [Refereed]
Minami M, Satoh M
Neuromolecular Medicine   7(1-2) 149-155   2005   [Refereed]
Ozawa T, Nakagawa T, Sekiya Y, Minami M, Satoh M
Eur. J. Neurosci.   19(1) 221-226   2004   [Refereed]
Fukui M, Takishita A, Zhang NN, Nakagawa T, Minami M, Satoh M
J. Pharmacol. Sci.   94(2) 153-160   2004   [Refereed]
Ide S, Minami M, Satoh M, Uhl GR, Sora I, Ikeda K
Neuropsychopharmacology.   29(9) 1656-1663   2004   [Refereed]
Bliss TM, Ip M, Cheng E, Minami M, Pellerin L, Magistretti P, Sapolsky RM
J. Neurosci.   24(27) 6202-6208   2004   [Refereed]
Nakagawa T, Katsuya A, Tanimoto S, Yamamoto J, Yamauchi Y, Minami M, Satoh M
Neurosci. Lett.   344(3) 197-200   2003   [Refereed]
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
Psychopharmacology   170(1) 80-88   2003   [Refereed]
Tanimoto S, Nakagawa T, Yamauchi Y, Minami M, Satoh M
Eur. J. Neurosci.   18(8) 2343-2350   2003   [Refereed]
Minami M, Satoh M
Life Sciences   74(2-3) 321-327   2003   [Refereed]
Watanabe T, Nakagawa T, Yamamoto R, Maeda A, Minami M, Satoh M
Japanese Journal of Pharmacology   88(4) 399-406   2002   [Refereed]
Takami S, Minami M, Katayama T, Nagata I, Namura S, Satoh M
Journal of Cerebral Blood Flow and Metabolism   22(7) 780-784   2002   [Refereed]
Katayama T, Minami M, Nakamura M, Ito M, Katsuki H, Akaike A, Satoh M
Neuroscience Letters   328(3) 277-280   2002   [Refereed]
Yamakuni H, Kawaguchi N, Ohtani Y, Nakamura J, Katayama T, Nakagawa T, Minami M, Satoh M
Journal of Neuroimmunology   129(1-2) 43-50   2002   [Refereed]
Minami M, Maekawa K, Yamakuni H, Katayama T, Nakamura J, Satoh M
Molecular Brain Research   107(1) 39-46   2002   [Refereed]
Okada M, Nakagawa T, Minami M, Satoh M
Journal of Pharmacology and Experimental Therapeutics   303(1) 66-73   2002   [Refereed]
Kume T, Nishikawa H, Taguchi R, Hashino A, Katsuki H, Kaneko S, Minami M, Satoh M, Akaike A
European Journal of Pharmacology   455(2-3) 91-100   2002   [Refereed]
Yenari MA, Minami M, Sun GH, Meier TJ, Kunis DM, McLaughlin JR, Ho DY, Sapolsky RM, Steinberg GK
Stroke   32(4) 1028-1035   2001   [Refereed]
Fukui M, Nakagawa T, Minami M, Satoh M
European Journal of Pharmacology   419(1) 25-31   2001   [Refereed]
Nakagawa T, Ozawa T, Shige K, Yamamoto R, Minami M, Satoh M
European Journal of Pharmacology   419(1) 39-45   2001   [Refereed]
Fukui M, Nakagawa T, Minami M, Satoh M
Japanese Journal of Pharmacology   86(4) 423-428   2001   [Refereed]
Ozawa T, Nakagawa T, Shige K, Minami M, Satoh M
Brain Research   905(1-2) 254-258   2001   [Refereed]
Minami M, Yamakuni H, Ohtani Y, Okada M, Nakamura J, Satoh M
Neuroscience Letters   311(1) 17-20   2001   [Refereed]
Chemokine receptor antagonist, viral MIP-II, protects brain against focal cerebral ischemia in mice.
Journal of Cerebral Blood Flow and Metabolism   21 1430-1435   2001
Nakagawa T, Minami M, Satoh M
European Journal of Pharmacology   433(1) 29-36   2001   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2008    Investigator(s): Masabumi MINAMI
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Masanori YAMAUCHI
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Takayuki NAKAGAWA
We have investigated the roles of spinal astrocytes in chronic pain. Intrathecal administration of ATP to rats produced short-lasting hyperalgesia (<20 min) and subsequently long-lasting allodynia, which appeared within 5 min, reached a plateau be...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Masabumi MINAMI
Monocyte chemoattractant protein-1(MCP-1,CCL2) is a well-defined CC chemokine implicated in the pathology of various types of brain injuries, such as ischemic and traumatic injuries. Previously, we demonstrated that MCP-1 production was upregulate...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Masamichi SATOH
μ-Opioid receptor, a receptor far morphine, is intensely expressed in the noradrenergic neurons located in the locus coeruleus.. These neurons project into various brain regions including the cerebral cortex, hippocampus and amygdala, and are impl...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2002    Investigator(s): Masabumi MINAMI
Production of chemokines and their receptors in the brain has been reported under various pathological conditions. In this study, we showed that intracerebroventricular and intravenous injections of TAK-779, a CCR2/ CCR5 selective chemokine recept...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2001    Investigator(s): Masamchi SATOH
We investigated the role of the amygdala in sensory and negative affective components of the pain experience in rats. We found that somatic noxious stimulus by intraplanter injection of formalin increased c-fos mRNA expression in lateral (LaA) and...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2001    Investigator(s): Masamchi SATOH
μ-Opioid receptors and their endogenous ligand are involved in the regulation of sensory and affective components of the pain experience. However, the molecular basis of the roles of opioidergic system in the higher brain functions, such as emotio...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2000    Investigator(s): Masabumi MINAMI
Fractalkine is a novel chemokine which has a CX3C motif and a membrane-bound form. We previously reported that, in the rat brain, fractalkine mRNA was expressed in neurons while the mRNA for its receptor (CX3CR1) was in microglia. This finding sug...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1997 - 1998    Investigator(s): Masamchi SATOH
We investigated the molecular mechanism responsible for supersensitization of the AC system induced by sustained opioid treatment using CHO cells expressing one of the cloned opioid receptors. In cells treated for 4 h with opioid agonists, challen...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1997 - 1998    Investigator(s): Masamchi SATOH
The nociceptin receptor was firstly cloned as an opioid receptor-like orphan receptor. Recently, nociceptin (orphanin FQ) has been isolated as an endogenous peptidic ligands of this orphan receptor, but the physiological and pathological roles of ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B), 基盤研究(B))
Project Year: 1995 - 1996    Investigator(s): Masamichi SATOH
Intracisternal injection of interleukin-1beta was shown to suppress naloxone-precipitated with-drawal syndrome in morphine dependent mouse. This effect of interleukin-1beta was mediated by CRF and prostaglandin E2. In order to clarify the target c...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B), 基盤研究(A))
Project Year: 1995 - 1996    Investigator(s): Masamichi SATOH
For the purpose to increase the sensitivity of an in situ hybridization technique with nonradioactive probes, we examined the several methods for nonradioactive labeling of RNA probes. Simiar sensitivities were obtained between digoxigenin- and fl...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1993 - 1994    Investigator(s): Masamichi SATOH
In this study, we conducted the following expeiments to elucidate the roles of brain interleukin-1beta in the modulation of nociceptive information. First, IL-1beta was intracerebroventriculary administrated and the nociceptive threshold to mechan...
Study on the neuronal mechanisms for pain-induced negative emotion
Study on the expressions and roles of cytokines and chemokines in the brain