Yoji Andrew Minamishima

Profile Information

Affiliation: Professor, Department of Biochemistry, Gunma University Graduate School of Medicine

Degree: M.D.(3 1993 Kyushu University)
Ph.D.(3 2002 Kyushu University)

Researcher number: 20593966
ORCID ID: https://orcid.org/0000-0001-7995-9318
J-GLOBAL ID: 201001049040159728

External link: http://biochemistry.med.gunma-u.ac.jp/en/

Research Areas

Research Interests

Research History

12 2018 - Present

Professor, Department of Biochemistry, Gunma University Graduate School of Medicine
4 2016 - 11 2018

Project Associate Professor, Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
9 2010 - 3 2016

Assistant Professor, Department of Biochemistry, Keio University School of Medicine
9 2010 - 3 2016

Group Leader, ERATO, Japan Science and Technology Agency (JST)
9 2004 - 8 2010

Research Fellow, Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School

Education

4 1998 - 3 2002

Kyushu University Graduate School of Medical Science
4 1987 - 3 1993

Kyushu University School of Medicine Department of Medicine

Professional Memberships

1993 - 1998

JAPAN SURGICAL SOCIETY
1993 - 1998

THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY
1993 - 1998

JAPAN SURGICAL ASSOCIATION
1998

The Molecular Biology Society of Japan
2002 - 2004

American Association for Cancer Research

Awards

Papers

Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.

Hiroaki Kikuchi, Emi Sasaki, Naohiro Nomura, Takayasu Mori, Yoji Andrew Minamishima, Yuki Yoshizaki, Naohiro Takahashi, Taisuke Furusho, Yohei Arai, Shintaro Mandai, Takahiro Yamashita, Fumiaki Ando, Yasuhiro Maejima, Kiyoshi Isobe, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara

Kidney international 95(1) 123 - 137 1 2019 Peer-reviewed
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.

Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima

Molecular and cellular biology 37(16) 8 15, 2017 Peer-reviewed
Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.

Koji Futatsugi, Hirobumi Tokuyama, Shinsuke Shibata, Makiko Naitoh, Takeshi Kanda, Hitoshi Minakuchi, Shintaro Yamaguchi, Koichi Hayashi, Yoji Andrew Minamishima, Motoko Yanagita, Shu Wakino, Hiroshi Itoh

Scientific reports 6 36533 - 36533 11 9, 2016 Peer-reviewed
Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.

Nobuyuki Tanaka, Takeo Kosaka, Yasumasa Miyazaki, Shuji Mikami, Naoya Niwa, Yutaro Otsuka, Yoji Andrew Minamishima, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Hisataka Sabe, Yasunori Okada, Per Uhlén, Makoto Suematsu, Mototsugu Oya

JCI insight 1(18) e83654 11 3, 2016 Peer-reviewed
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.

Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G Kaelin Jr, Makoto Suematsu, Yoji Andrew Minamishima

Proceedings of the National Academy of Sciences of the United States of America 112(37) 11642 - 7 9 15, 2015 Peer-reviewed

Books and Other Publications

全人力・科学力・透析力・for the people 透析医学

南嶋洋司(Role: Contributor, 成人肝細胞での低酸素応答をターゲットとした腎性貧血治療法の可能性)

医薬ジャーナル社 6 2014 (ISBN: 9784753226795)
見つける、量る、可視化する！質量分析実験ガイド

南嶋洋司(Role: Contributor, 10 細胞のエネルギー代謝を量る低酸素環境下での代謝フラックスの定量)

羊土社 3 2013 (ISBN: 9784758101868)

Misc.

血中スフィンゴシン1リン酸の産生および分解過程におけるキャリアタンパク質の役割

清塚啓介, Zhao Xian, 南嶋洋司, 大日方英

日本生化学会大会プログラム・講演要旨集 93回 [1Z02 - 055)] 9 2020
新しい腎性貧血治療薬としてのHIF-PHD阻害薬〜これを聞けば全てが分かります〜 HIF-PH阻害剤低酸素応答が個体に与える影響

南嶋洋司

日本腎臓学会誌 62(4) 238 - 238 7 2020
Hypoxic response as a therapeutic target of human diseases

Andrew Minamishima Yoji

Folia Pharmacologica Japonica 155(1) 40 - 45 1 2020
恩師の2019年ノーベル医学生理学賞｢酸素濃度の感知と低酸素への適応｣受賞に寄せて : 弟子から見たDr. William "Bill" G. Kaelin Jr.

南嶋洋司

科学 89(12) 1137 - 1140 12 2019
BRCA1複合体による機能不全テロメアにおける細胞周期特異的なDNA損傷修復の制御機構(BRCA1 complex regulates cell cycle-dependent DNA damage repair at telomeres to maintain chromosome integrity)

小西昭充, 南嶋洋司

日本癌学会総会記事 78回 P - 3241 9 2019

Research Projects

敗血症性心筋障害治療における低酸素応答依存的トリプトファン代謝の分子機構の解明

日本学術振興会科学研究費助成事業基盤研究(C)

南嶋しづか, 南嶋洋司
水酸化オミクス解析を駆使した低酸素応答による代謝制御機構の全貌解明

日本学術振興会科学研究費助成事業基盤研究(B)

南嶋洋司, 菱木貴子, 久保亜紀子
Investigation of hypoxia adaptation and metabolic regulation in the cancer- and senescence-resistant rodent, the naked mole rat.

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Miura Kyoko
Identification of the specific metabolic system for cellular senescence and tumorigenesis

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Minamishima Yoji Andrew, Akiko Kubo, Takako Hishiki, Yuki Sugiura
Maintenance of CML stem cells through regulation of C/EBPbeta transcription factor

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Hirai Hideyo, MINAMISHIMA Yoji, MAEKAWA Taira, YOKOTA Asumi

Industrial Property Rights

US2019/0151315A1 Drug For Preventing Or Treating Lactic Acidosis

Yoji Andrew Minamishima, Tomohiro Suhara, Tomoko Toramaru, Kyoji Yamaguchi
WO2017-175859 乳酸アシドーシスの予防又は治療のための医薬

南嶋洋司, 寅丸智子, 壽原朋宏, 山口京二

Committee Memberships

10 2013 - Present

Cancer and Metabolism Meeting Executive committee

Teaching Experience

2019

基礎生物学実習 (群馬大学医学部)
2019

生化学実習 (群馬大学医学部)
2019

生化学講義 (群馬大学医学部)
2011 - 2016

医化学実習 (慶應義塾大学医学部)
2011 - 2015

博士課程『医科学方法論』 (慶應義塾大学大学院医学研究科)

Social Activities

低酸素に対する応答反応と、その病気の治療への応用

Guest, Lecturer

科学技術振興機構科学ライブショー「ユニバース」ノーベル賞特別番組科学技術館 12 14, 2019 - 12 14, 2019
75

ぐんまちびっ子大学

Logistic support

群馬大学ヤマダ電機LABI1 LIFE SELECT 高崎 8 10, 2019 - 8 13, 2019
群馬大学公開講座世界脳週間2019

Guest, Performer

NPO特定非営利活動法人「脳の世紀推進会議」世界脳週間2019 群馬大学医学部 6 16, 2019 - 6 16, 2019
キャリアトーク

Lecturer

独立行政法人科学技術振興機構(JST) サイエンス・パートナーシップ・プロジェクト (SPP) 7 27, 2013 - 7 27, 2013
低酸素の生物学

Lecturer

独立行政法人科学技術振興機構(JST) サイエンス・パートナーシップ・プロジェクト (SPP) 11 15, 2012 - 11 22, 2012

Other

低酸素応答による「乳酸からの糖新生」の制御〜その分子メカニズムの解明から乳酸アシドーシス治療法の開発へ〜

7 2017 - 7 2017

肝細胞研究会ホットトピックス http://hepato.umin.jp/hottopics/hottopics015.html
Post-doctoral training先の選び方

8 2015 - 8 2015

海外日本人研究者ネットワーク United Japanese researchers Abroad (UJA) http://uja-info.org/findingourway/post/1316/

Profile Information

Research Areas

Research Interests

Research History

Education

Professional Memberships

Awards

Papers

Books and Other Publications

Misc.

Research Projects

Industrial Property Rights

Committee Memberships

Teaching Experience

Social Activities

Other

Menu

Coauthors