論文

査読有り
2000年

Tea catechins and related polyphenols as anti-cancer agents

BioFactors
  • M. Isemura
  • ,
  • K. Saeki
  • ,
  • T. Kimura
  • ,
  • S. Hayakawa
  • ,
  • T. Minami
  • ,
  • M. Sazuka

13
1-4
開始ページ
81
終了ページ
85
記述言語
掲載種別
研究論文(国際会議プロシーディングス)
DOI
10.1002/biof.5520130114

Epigallocatechin gallate (EGCg) and theaflavins, a major constituent of green tea infusion and the constituents of black tea, respectively, were found to inhibit matrix metalloproteinases (MMPs) which are intimately associated with tumor invasion and metastasis. EGCg and related polyphenols exhibited apoptosis-inducing activity for several cancer cell lines including human stomach and colon cancer cells. Comparison of the activity of these compounds revealed the importance of the number and the steric disposition of hydroxyl groups. A pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction of catechin compounds and that in the B ring has an important role in the activity. These data would provide useful information for designing anti-cancer agents on the basis of anti-inhibitory activity for MMPs and/or apoptosis-inducing activity.

リンク情報
DOI
https://doi.org/10.1002/biof.5520130114
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11237204
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034490737&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0034490737&origin=inward

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