論文

査読有り 筆頭著者
2016年5月

Cutaneous epitheliotropic T-cell lymphoma with systemic dissemination in a dog

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
  • Takayuki Mineshige
  • ,
  • Shinpei Kawarai
  • ,
  • Takahiro Yauchi
  • ,
  • Kazuhito Segawa
  • ,
  • Sakurako Neo
  • ,
  • Go Sugahara
  • ,
  • Junichi Kamiie
  • ,
  • Masaharu Hisasue
  • ,
  • Kinji Shirota

28
3
開始ページ
327
終了ページ
331
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/1040638716637642
出版者・発行元
SAGE PUBLICATIONS INC

Cutaneous epitheliotropic T-cell lymphoma (CETL) is characterized by neoplastic T-cell infiltration of the epidermis, adnexal structures, and oral mucosa. The objective of this report was to describe the pathological findings of a canine case of terminal-stage CETL. A 10-year-old, mixed-breed, neutered male dog was presented with erosion of the oral mucosa and mucocutaneous junction. The dog was diagnosed with CETL with no evidence of metastasis. Despite chemotherapy, the dog was re-presented with oral pain, vomiting, and diarrhea, and died 17 months after the first visit to the hospital. A complete autopsy was performed. Histologic examination of the primary lesion and systemic organs was performed. Gross examination revealed an advanced-stage oral lesion. Distinct tumor formation was not observed in the primary sites and systemic organs. Histologically, the primary oral lesion was characterized by massive intraepithelial infiltration of a large number of neoplastic lymphocytes. The neoplastic cells in the metastatic sites also showed exclusive epitheliotropic proliferation in organs, including the trachea, tonsils, esophagus, stomach, small intestine, colon, anal mucosa, liver, pancreas, kidneys, urinary bladder, prostate gland, ear canals, and auricular and ventral skin. Immunohistochemically, the neoplastic cells were positive for CD3 and negative for CD20 as well as CD79, supporting a diagnosis of CETL with systemic dissemination. In canine CETL with systemic signs, systemic metastasis should be considered even without evident mass formation. Neoplastic lymphocytes of CETL showed distinct epitheliotropism even in the systemic metastatic sites.

リンク情報
DOI
https://doi.org/10.1177/1040638716637642
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26951331
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375712100022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1177/1040638716637642
  • ISSN : 1040-6387
  • eISSN : 1943-4936
  • PubMed ID : 26951331
  • Web of Science ID : WOS:000375712100022

エクスポート
BibTeX RIS