論文

査読有り
2017年1月

Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of 423 Japanese patients during a long-term follow-up: The JUDE study

MODERN RHEUMATOLOGY
  • Kentaro Minowa
  • ,
  • Hirofumi Amano
  • ,
  • Seiichiro Ando
  • ,
  • Takashi Watanabe
  • ,
  • Michihiro Ogasawara
  • ,
  • Shinya Kawano
  • ,
  • Toshiyuki Kaneko
  • ,
  • Shinji Morimoto
  • ,
  • Ken Yamaji
  • ,
  • Naoto Tamura
  • ,
  • Yoshiaki Tokano
  • ,
  • Hiroshi Hashimoto
  • ,
  • Yoshinari Takasaki

27
1
開始ページ
72
終了ページ
76
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/14397595.2016.1192745
出版者・発行元
SPRINGER

Objective: To clarify the clinical features of systemic lupus erythematosus (SLE) patients, factors associated with flares, and changes over time.
Methods: Patients having SLE with a visiting history were entered into the Juntendo University Database of Erythematosus. We included 423 cases in the long-term follow-up analysis, and 383 cases were followed for 10 years after the initiation of any therapeutic intervention (comparative analysis: 1973-1982, 82 cases; 1983-1992, 141, and 1993-2002, 160). We assessed changes in the patients' background characteristics, disease symptoms, flare rates, etc.
Results: Among the 423 cases, the mean follow-up period was 25.9 years, and mean number of flares was 0.51. Of those, 31.9% had >= 1 flares. Thrombocytopenia at onset contributed to the flares. For disease symptoms at onset, a recent trend in increasing thrombocytopenia was observed. The combination rate of immunosuppressive agents for diseases other than lupus nephritis was slightly increased, and there was no improvement until the first flare or in the flare rate.
Conclusions: Thrombocytopenia at onset is predictive factor for flares. Since SLE is a diverse disease with varying symptoms at recurrence, the treatment guidelines should be improved for thrombocytopenia from a long-term perspective.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1080/14397595.2016.1192745
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27539069
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393319100012&DestApp=WOS_CPL

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