論文

査読有り
2016年

The synovial grade corresponding to clinically involved joints and a feasible ultrasound-adjusted simple disease activity index for monitoring rheumatoid arthritis

MODERN RHEUMATOLOGY
  • Yusuke Yamada
  • ,
  • Michihiro Ogasawara
  • ,
  • Misa Gorai
  • ,
  • Yuko Matsuki
  • ,
  • Go Murayama
  • ,
  • Nagachika Sugisaki
  • ,
  • Takuya Nemoto
  • ,
  • Seiichiro Ando
  • ,
  • Kentaro Minowa
  • ,
  • Souichiro Nakano
  • ,
  • Takayuki Kon
  • ,
  • Kurisu Tada
  • ,
  • Masakazu Matsushita
  • ,
  • Ken Yamaji
  • ,
  • Naoto Tamura
  • ,
  • Yoshinari Takasaki

26
6
開始ページ
844
終了ページ
849
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3109/14397595.2016.1158385
出版者・発行元
SPRINGER

Objectives: To determine which grade of ultrasound (US) synovitis corresponds to clinically involved joints in rheumatoid arthritis (RA) and develops a new US-adjusted composite measure.
Methods: Clinical and US examinations were performed on 137 patients with RA (28 joints). Synovial effusion, hypertrophy, and blood flow were semiquantitatively graded from 0 to 3 using gray scale (GS) and power Doppler (PD) modes. We calculated US-adjusted simple disease activity index (SDAI) and assessed feasibility, and external validity by comparing with erythrocyte sedimentation rate (ESR), and modified health assessment questionnaires (MHAQ).
Results: GS >= 2 and PD >= 0 corresponds to clinically swollen joints, and GS >= 2 and PD >= 1 corresponds to tender joints. The US-adjusted SDAI showed the highest correlation when US-determined swollen joints were defined as PD >= 2 with ESR, and GS >= 3 and PD >= 2 with MHAQ. A feasible US-adjusted SDAI examining only clinically involved joints still showed a higher correlation with ESR and MHAQ than SDAI.
Conclusion: Our composite measure complemented by US only for clinically involved joints is feasible and reliable for monitoring disease activity.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.3109/14397595.2016.1158385
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26913787
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393121500007&DestApp=WOS_CPL

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