2005年11月
Synthesis and biological activity of fatty acid derivatives of quinine
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 69
- 号
- 11
- 開始ページ
- 2250
- 終了ページ
- 2253
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1271/bbb.69.2250
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.
- リンク情報
- ID情報
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- DOI : 10.1271/bbb.69.2250
- ISSN : 0916-8451
- eISSN : 1347-6947
- Web of Science ID : WOS:000233710900034