Jan, 2009
Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts)
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- Volume
- 73
- Number
- 1
- First page
- 217
- Last page
- 220
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1271/bbb.80571
- Publisher
- TAYLOR & FRANCIS LTD
Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.
- Link information
- ID information
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- DOI : 10.1271/bbb.80571
- ISSN : 0916-8451
- eISSN : 1347-6947
- Web of Science ID : WOS:000263133400040