Minoru Kimura - My portal

Profile Information

Affiliation: Brain Science Institute, Tamagawa University
: (Concurrent)特別研究員（客員教授）

Degree: 医学博士(東京大学)

J-GLOBAL ID: 201101019170001949
researchmap Member ID: B000001736

Research Interests

Research Areas

Research History

2010 - Present

Brain Science Institute, Tamagawa University
2003 - 2010

Kyoto Prefectural University of Medicine
2000 - 2003

Kyoto Prefectural University of Medicine
1999 - 2000

Osaka University
1997 - 1999

教授, 医学系研究科情報伝達医学専攻協力講座, 大阪大学大学院
1992 - 1997

Osaka University
1990 - 1992

助教授, 高次液性調節研究部門, 国立生理学研究所
1989 - 1990

School of Medicine, Jichi Medical University
1980 - 1989

School of Medicine, Jichi Medical University

Awards

Papers

Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.

Satoshi Nonomura, Kayo Nishizawa, Yutaka Sakai, Yasuo Kawaguchi, Shigeki Kato, Motokazu Uchigashima, Masahiko Watanabe, Ko Yamanaka, Kazuki Enomoto, Satomi Chiken …

Neuron, 99(6) 1302-1314, Sep 19, 2018 Peer-reviewed
Area-specific Modulation of Functional Cortical Activity During Block-based and Trial-based Proactive Inhibition.

Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Ríos A, Kawabata M, Kimura M, Sakai Y, Isomura Y

Neuroscience, 388 297-316, Sep, 2018 Peer-reviewed
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.

Ko Yamanaka, Yukiko Hori, Takafumi Minamimoto, Hiroshi Yamada, Naoyuki Matsumoto, Kazuki Enomoto, Toshihiko Aosaki, Ann M Graybiel, Minoru Kimura

Journal of neural transmission (Vienna, Austria : 1996), 125(3) 501-513, Mar, 2018 Peer-reviewed
Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection

Yasumasa Ueda, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Naoyuki Matsumoto, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Kae Nakamura …

FRONTIERS IN NEUROANATOMY, 11 66, Aug, 2017 Peer-reviewed
In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.

Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y

Cerebral cortex (New York, N.Y. : 1991), 28(3) 1024-1038, Jan, 2017 Peer-reviewed
Characteristics of fast-spiking neurons in the striatum of behaving monkeys

Hiroshi Yamada, Hitoshi Inokawa, Yukiko Hori, Xiaochuan Pan, Ryuichi Matsuzaki, Kae Nakamura, Kazuyuki Samejima, Munetaka Shidara, Minoru Kimura, Masamichi Sakagami …

NEUROSCIENCE RESEARCH, 105 2-18, Apr, 2016 Peer-reviewed
Activity in the Nucleus Accumbens and Amygdala Underlies Individual Differences in Prosocial and Individualistic Economic Choices

Masahiko Haruno, Minoru Kimura, Christopher D. Frith

JOURNAL OF COGNITIVE NEUROSCIENCE, 26(8) 1861-1870, Aug, 2014 Peer-reviewed
Enhancement of alcohol drinking in mice depends on alterations in RNA editing of serotonin 2C receptors.

Yoshihisa Watanabe, Kanji Yoshimoto, Harutsugu Tatebe, Masakazu Kita, Kazuko Nishikura, Minoru Kimura, Masaki Tanaka

The international journal of neuropsychopharmacology, 17(5) 739-51, May, 2014 Peer-reviewed
Neural signal for counteracting pre-action bias in the centromedian thalamic nucleus

Takafumi Minamimoto, Yukiko Hori, Ko Yamanaka, Minoru Kimura

Frontiers in Systems Neuroscience, 8(3), Jan 28, 2014 Peer-reviewed
Coding of the long-term value of multiple future rewards in the primate striatum.

Hiroshi Yamada, Hitoshi Inokawa, Naoyuki Matsumoto, Yasumasa Ueda, Kazuki Enomoto, Minoru Kimura

Journal of neurophysiology, 109(4) 1140-51, Feb, 2013 Peer-reviewed
Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior

Kanji Yoshimoto, Yoshihisa Watanabe, Masaki Tanaka, Minoru Kimura

EUROPEAN JOURNAL OF NEUROSCIENCE, 35(8) 1368-1380, Apr, 2012 Peer-reviewed
Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement

Yoland Smith, D. James Surmeier, Peter Redgrave, Minoru Kimura

JOURNAL OF NEUROSCIENCE, 31(45) 16102-16106, Nov, 2011 Peer-reviewed
Dopamine neurons learn to encode the long-term value of multiple future rewards

Kazuki Enomoto, Naoyuki Matsumoto, Sadamu Nakai, Takemasa Satoh, Tatsuo K. Sato, Yasumasa Ueda, Hitoshi Inokawa, Masahiko Haruno, Minoru Kimura

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(37) 15462-15467, Sep, 2011 Peer-reviewed
Neuronal basis for evaluating selected action in the primate striatum

Hiroshi Yamada, Hitoshi Inokawa, Naoyuki Matsumoto, Yasumasa Ueda, Minoru Kimura

EUROPEAN JOURNAL OF NEUROSCIENCE, 34(3) 489-506, Aug, 2011 Peer-reviewed
Inactivation of the putamen selectively impairs reward history-based action selection

Manabu Muranishi, Hitoshi Inokawa, Hiroshi Yamada, Yasumasa Ueda, Naoyuki Matsumoto, Masanori Nakagawa, Minoru Kimura

EXPERIMENTAL BRAIN RESEARCH, 209(2) 235-246, Mar, 2011 Peer-reviewed
JUXTACELLULAR LABELING OF TONICALLY ACTIVE NEURONS AND PHASICALLY ACTIVE NEURONS IN THE RAT STRIATUM

H. Inokawa, H. Yamada, N. Matsumoto, M. Muranishi, M. Kimura

NEUROSCIENCE, 168(2) 395-404, Jun, 2010 Peer-reviewed
Neuronal Encoding of Reward Value and Direction of Actions in the Primate Putamen

Yukiko Hori, Takafumi Minamimoto, Minoru Kimura

JOURNAL OF NEUROPHYSIOLOGY, 102(6) 3530-3543, Dec, 2009 Peer-reviewed
Optical imaging of interaural time difference representation in rat auditory cortex

Vassiliy Tsytsarev, Hidenao Fukuyama, Daniel Pope, Elena Pumbo, Minoru Kimura

Frontiers in Neuroengineering, 2 2, Mar 2, 2009 Peer-reviewed
Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action

Takafumi Minamimoto, Yukiko Hori, Minoru Kimura

BRAIN RESEARCH BULLETIN, 78(2-3) 75-79, Feb, 2009 Peer-reviewed
History- and current instruction-based coding of forthcoming behavioral outcomes in the striatum

Hiroshi Yamada, Naoyuki Matsumoto, Minoru Kimura

JOURNAL OF NEUROPHYSIOLOGY, 98(6) 3557-3567, Dec, 2007 Peer-reviewed

Misc.

パーキンソン病におけるニューロンの選択的脆弱性に対する治療の意義（座談会）

Frontiers in Parkinson Disease, 7(4) 191-197, Nov, 2014 Invited
大脳基底核の内ループ

山中航, 木村實

Annual Review 2013 神経, 68-74, Jan, 2013 Invited
「視床随板内核」（気になる脳部位）

山中航, 木村實

分子精神医学, 12(2) 55-30, Apr, 2012 Invited
意思決定と行動発現を支える神経回路基盤 ―霊長類モデルを中心に

榎本一紀, 木村實

実験医学増刊号『in vivo 実験医学によるヒト疾患解明の最前線』, 30(2) 114-120, Jan, 2012 Invited
セロトニン2C受容体のRNA編集変化によるアルコール嗜好性の決定

渡邊義久, 吉本寛司, 建部陽嗣, 西倉和子, 木村實, 田中雅樹

日本分子生物学会年会プログラム・要旨集(Web), 35th WEB ONLY 3P-0661, 2012
Adaptation of reward-based free-choices is impaired by cannabinoid receptor (CB1) antagonist

OKAZAKI Satoru R, UEDA Yasumasa, YAMANAKA Ko, ENOMOTO Kazuki, INOKAWA Hitoshi, YAGITA Kazuhiro, MATSUMOTO Naoyuki, KANO Masanobu, KIMURA Minoru

J Physiol Sci, 62(Supplement 1) S234, 2012
Increased voluntary alcohol drinking behavior is associated with the role of serotonin 2c receptors in alcohol vapor- exposed C57BL/6J mice

YOSHIMOTO Kanji, WATANABE Yoshihisa, TANAKA Masaki, IKEGAYA Hiroshi, KIMURA Minoru

神経化学, 49(2/3) 755, Aug 1, 2010
Dopamine neurons in ventromedial and dorsolateral part of the midbrain differentially encode reward value and its error

ENOMOTO Kazuki, MATSUMOTO Naoyuki, HARUNO Masahiko, KIMURA Minoru

神経化学, 49(2/3) 654, Aug 1, 2010
RNA-editing frequency of serotonin 2C receptor is increased by chronic alcohol exposure

WATANABE Yoshihisa, YOSHIMOTO Kanji, TATEBE Harutsugu, KIMURA Minoru, TANAKA Masaki

神経化学, 49(2/3) 755, Aug 1, 2010
Signals of reward value and actions represented in the neuronal activity of CM thalamus

YAMANAKA Ko, YAMANAKA Ko, HORI Yukiko, HORI Yukiko, UEDA Yasumasa, MINAMIMOTO Takafumi, KIMURA Minoru, KIMURA Minoru

神経化学, 49(2/3) 658, Aug 1, 2010
報酬に基づく意思決定と行動選択に線条体と視床髄板内核はどのように関わるか?

木村實

分子レベルからの脳機能構築機構の解明平成16-21年度 No.16070101, 381, 2010
報酬に基づく意思決定と行動選択に線条体と視床髄板内核はどのように関わるか?

木村實

脳の神経回路の機能解明平成16-21年度 No.16069101, 309, 2010
大脳皮質基底核系のアクション・認知機能における動機づけの役割

木村實

脳の高次機能システム平成16-21年度 No.16068101, 132-135, 2010
報酬に基づく意思決定と行動選択に線条体と視床髄板内核はどのように関わるか?

木村實

脳の高次機能システム平成16-21年度 No.16068101, 291, 2010
報酬に基づく意思決定と行動選択に線条体と視床髄板内核はどのように関わるか?

木村實

脳の病態解明平成16-21年度 No.16071101, 293, 2010
報酬に基づく意思決定と行動選択に線条体と視床髄板内核はどのように関わるか?

木村實

脳機能の統合的研究平成16-21年度 No.16067101, 293, 2010
Neuronal activity of CM thalamus during reward-bias task of monkey

YAMANAKA Ko, HORI Yukiko, UEDA Yasumasa, KIMURA Minoru

Neurosci Res, 65(Supplement 1) S106, 2009
Dopamine neurons encode multi-step future rewards and their errors

ENOMOTO Kazuki, MATSUMOTO Naoyuki, KIMURA Minoru

Neurosci Res, 65(Supplement 1) S114, 2009
INVOLVEMENT OF THE BASAL GANGLIA IN VALUATION AND SELECTION OF ACTIONS

KIMURA Minoru, YAMADA Hiroshi, ENOMOTO Kazuki, MATSUMOTO Naoyuki, HORI Yukiko, UEDA Yasumasa, NAKAYAMA Ko

J Physiol Sci, 59(Supplement 1) 48, 2009
Inactivation of the putamen impairs action value-based selectionbut not estimation of values during multi-step choice task in monkeys

MURANISHI Manabu, INOKAWA Hitoshi, YAMADA Hiroshi, KIMURA Minoru

Neurosci Res, 65(Supplement 1) S192, 2009

Books and Other Publications

Neuroeconomics, Second Edition: Decision-Making and the Brain

Doya K, Kimura M (Role: Joint author, The Basal Ganglia, Reinforcement Learning and the Encoding of Value)

Academic Press, Sep, 2013 (ISBN: 9780124160088)
Encyclopedia of Neuroscience

Kimura M, Ueda Y (Role: Joint author, Sensorimotor Learning and the Basal Ganglia)

Springer, Oct, 2009 (ISBN: 9783540237358)
Neuroeconomics: Decision Making and the Brain

Doya K, Kimura M (Role: Joint author, The basal ganglia and the encoding of value.)

Academic Press, Oct, 2008 (ISBN: 9780123741769)
Recent Breakthroughs in Basal Ganglia Research.

Kimura M, Satoh T, Sato T, Enomoto, K, Matsumoto N (Role: Joint author, Motivational Signals of Dopamine Neurons.)

Nova Science Publishers, Dec, 2006 (ISBN: 9781594548802)
Microcircuits : The interface between neurons and global brain function*

Bergman H, Kimura M, Wickens J.R (Role: Joint author, Modulation of striate circuits by dopamine and acetylcholine.)

The MIT press, Sep, 2006
Microcircuits : The interface between neurons and global brain function

Bergman H, Graybiel AM, Kimura M, Plenz D, Seung HS, Surmeier DJ, Wickens JR (Role: Joint author, Microcircuits, molecules and motivated behavior – microcircuits in the striatum.)

The MIT press, Sep, 2006 (ISBN: 9780262072786)

Presentations

Roles of thalamostriatal projection from posterior intralaminar nuclei in associative learning of external events

Minoru Kimura

国際シンポジウムComputational Basal Ganglia, Dec 14, 2016, National Institute for Physiological Science Invited
Activity of dopamine D2 receptor-expressing striatal neurons during decision-making task

S. Nonomura, K. Yamanaka, K. Nishizawa, K. Kobayashi, Y. Sakai, Y. Kawaguchi, A. Nambu, Y. Isomura, M. Kimura

The 39th Annual Meeting of the Japan Neuroscience Society, Jul 22, 2016, Japan Neuroscience Society
Roles of nigrostriate and thalamostriate systems in motivation and learning

Minoru Kimura

The Third CiNet Conference Neural mechanisms of decision making: Achievements and new directions, Feb 5, 2016, NICT,Center for information and Neural Networks(CiNet/NICT) Invited
Roles of the centromedian nucleus of thalamus and its projection to the striatum in cognitive and behavioral biases

Kimura M, Yamanaka K, Minamimoto T, Hori Y, Ueda Y

Neuroscience 2015, SfN's 45th annual meeting, Oct 21, 2015, Society for Neuroscience
Centromedian nucleus of thalamus exhibits neuron circuit-specific signals during a new learning of action-outcome associations

Ko Yamanaka, Yukiko Hori, Yasumasa Ueda, Kazuki Enomoto, Takafumi Minamimoto, Minoru Kimura

Jul 28, 2015, Japan Neuroscience Society
大脳基底核による行動選択と学習機能

Minoru Kimura

Jul 19, 2015, Japan Basal Ganglia Society：JBAGS Invited
Neural basis of congnitive control of behavior in the centromedian nucleus of thalamus and its projection to the striatum

Kimura M, Yamanaka K, Minamimoto T, Hori T, Ueda Y

Thalamus and Corticothalamic Interactions, Apr 27, 2015, Janelia Rserch Campus Invited
大脳基底核の機能におけるドーパミンの役割

木村實

エビリファイ発売8周年記念講演会第2回ドーパミンシステムを再考する, Nov 29, 2014 Invited
The role of endocannabinoid signaling in the striatum for reinforcement learning

Yasumasa Ueda, Satoru R Okazaki, Ko Yamanaka, Kazuyuki Samejima, Kazuki Enomoto, Masanobu Kano, Minoru Kimura

Sep 12, 2014, Japan Neuroscience Society
Heterogeneous reward signals of midbrain dopamine neurons in over-trained monkeys

Kazuki Enomoto, Naoyuki Matsumoto, Masahiko Harun, Minoru Kimura

Neuroscience 2014, Sep 11, 2014, Japan Neuroscience Society
Monitoring action bias and external demands in the centromedian nucleus of thalamus

Ko Yamanaka, Yukiko Hori, Yasumasa Ueda, Takafumi Minamimoto, Minoru Kimura

Neuroscience 2014, Sep 11, 2014, Japan Neuroscience Society
Dopamine neurons evolve to signal future rewards expected across blocks of multiple choices when monkeys are overtrained

Kazuki Enomoto, Naoyuki Matsumoto, Minoru Kimura

Neuroscience 2013, SfN's 43nd annual meeting, Nov 13, 2013, Society for Neuroscience
Optimization of reward-based response bias through the CM-striatum projection.

Yamanaka K, Kimura M

Neuro2013, Jun 22, 2013, Japan Neuroscience Society
Midbrain dopamine neuron signals supra-long term minimum-discounted future rewards in over-trained monkeys.

Enomoto K, Matsumoto N, Kimura M

Neuro2013, Jun 22, 2013, Japan Neuroscience Society
Striatal event-related activity reflects intrinsic discount rate in a multi-step reward task.

Tanaka S, Takaoka M, Yoneda H, Enomoto K, Samejima K, Haruno M, Kimura M, Ohtake F

Neuro2013, Jun 20, 2013, Japan Neuroscience Society
大脳基底核における意志決定の神経機構

minoru kimura

つくばブレインサイエンスセミナー第200回記念特別講演会, Feb 9, 2013 Invited
大脳基底核における意志決定の神経機構

minoru kimura

京都府立医科大学生理学教室130周年記念シンポジウム, Feb 2, 2013 Invited
Impairment of reward-based adaptive choice of actions by local injection of cannabinoid CB1 receptor antagonist into the striatum of behaving monkeys

Ueda Y, Okazaki S. R, Yamanaka K, Enomoto K, Kano M, Kimura M

Oct 17, 2012, Society for Neuroscience
Signals projected from the centromedian nucleus of thalamus to the putamen during reward-based action selection in monkey

Yamanaka K, Kimura M

Neuroscience 2012, SfN's 42nd annual meeting, Oct 15, 2012, Society for Neuroscience
Activity in the nucleus accumbens and amygdala encodes prosocial and individualistic intuitions in social decision making.

Haruno M, Kimura M, Frith CD

Neuroscience 2012, SfN's 42nd annual meeting, Oct 15, 2012, Society for Neuroscience

Professional Memberships

Research Projects

光遺伝学を用いた線条体直接路・間接路細胞の学習メカニズム

科学研究費助成金（挑戦的萌芽研究）, 文部科学省, Apr, 2015 - Mar, 2017

木村實
視床CM核―線条体系による行動選択の学習と制御の神経回路基盤

科学研究費補助金(基盤研究(B)), 文部科学省, Apr, 2014 - Mar, 2017

木村實
Neuronal basis of prediction and decision in the basal ganglia and amygdala.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, 2011 - 2015

KIMURA Minoru, HARUNO Masahiko, SAMEJIMA Kazuyuki, ENOMOTO Kazuki, YAMANAKA Ko
社会的行動を支える脳基盤の計測・支援技術の開発「霊長類モデルによる意思決定と行動発現を支える神経回路基盤と制御」

脳科学研究戦略推進プログラム, 文部科学省, Apr, 2010 - Mar, 2014

木村實
包括型脳科学研究推進支援ネットワーク

科学研究費補助金, 文部科学省, 2010 - 2014

木村實, 丹治順, 村山繁雄, 笠井清登, 崎村建司, 小林和人
Involvement of dopamine system and orbito frontal cortex in update and memory of value signals

Grants-in-Aid for Scientific Research(基盤研究(A)), 基盤研究(A), Ministry of Education, Culture, Sports, Science and Technology, 2008 - 2010

Minoru KIMURA, Naoyuki MATSUMOTO
Role of the cortico-basal ganglia system in action and cognition

Grants-in-Aid for Scientific Research(特定領域研究), 特定領域研究, Ministry of Education, Culture, Sports, Science and Technology, 2005 - 2010

Minoru KIMURA, 伏木信次, 中川正法, 上田康雅, Shinji FUSHIKI, Masanori NAKAGAWA, Yasumasa UEDA
System study on higher-order brain functions

Grants-in-Aid for Scientific Research(特定領域研究), 特定領域研究, Ministry of Education, Culture, Sports, Science and Technology, 2004 - 2010

Minoru KIMURA, 小松英彦, 田中啓治, 福島菊郎, 川人光男, 泰羅雅登, Hidehiko KOMATSU, Keiji TANAKA, Kikuro FUKUSHIMA, Mitsuo KAWATO, Masato TAIRA, Kuniyoshi SAKAI
Role of the basal ganglia in modification of action and cognition signals by motivation

Grants-in-Aid for Scientific Research(基盤研究(B)), 基盤研究(B), Ministry of Education, Culture, Sports, Science and Technology, 2002 - 2004

Minoru KIMURA, Yasumasa UEDA, Naoyuki MATSUMOTO
Neural organization of learning and thought in the cortico-basal ganglia system

Grants-in-Aid for Scientific Research(特定領域研究(C), 特定領域研究), 特定領域研究(C), 特定領域研究, Ministry of Education, Culture, Sports, Science and Technology, 2000 - 2004

Minoru KIMURA, Minoru MATSUMOTO, Yasumasa UEDA
Neural mechanisms for the selection of behavior and for the strategy of movement

Grants-in-Aid for Scientific Research(重点領域研究, 特定領域研究(A)), 重点領域研究, 特定領域研究(A), Ministry of Education, Culture, Sports, Science and Technology, 1996 - 1999

Minoru KIMURA, Noboru MIZUNO, Hiroshi SHIBASAKI, 川人光男, Okihide HIKOSAKA, Jun TANJI, Mitsuo KAWATO
Role of the basal ganglia in learning and initiation of purposeful behavior

Grants-in-Aid for Scientific Research(基盤研究(A)), 基盤研究(A), Ministry of Education, Culture, Sports, Science and Technology, 1995 - 1997

Minoru KIMURA, Naoyuki MATSUMOTO
Functinal Role of Modular Organization in the Basal Ganglia

Grants-in-Aid for Scientific Research(一般研究(B)), 一般研究(B), Ministry of Education, Culture, Sports, Science and Technology, 1993 - 1994

木村実, Minoru KIMURA, Naoyuki MATSUMOTO
運動のプログラムと制御に関与する大脳基底核の後割

科学研究費補助金(重点領域研究), 重点領域研究, 文部科学省, 1992 - 1992

木村実, 木村實
運動のプログラムと制御に関与する大脳基底核の役割

科学研究費補助金(重点領域研究), 重点領域研究, 文部科学省, 1991 - 1991

木村実, 青崎敏彦
被殻ー淡蒼球系と尾状核ー黒質系が随意運動の発現と制御に果たす役割の相違

科学研究費補助金(一般研究(C)), 一般研究(C), 文部科学省, 1991 - 1991

木村実, 青崎敏彦
運動のプログラムと制御に関与する大脳基底核の役割

科学研究費補助金(重点領域研究), 重点領域研究, 文部科学省, 1990 - 1990

木村実
大脳基底核内の神経情報処理における黒質線条体ドーパミン系の役割

科学研究費補助金(一般研究(C)), 一般研究(C), 文部科学省, 1988 - 1988

木村実
随意運動発現の神経機序における被殼-淡蒼球系の役割

科学研究費補助金(一般研究(C)), 一般研究(C), 文部科学省, 1986 - 1986

木村実
髄意運動発現における大脳基底核の役割-神経生理学的研究-

科学研究費補助金(特定研究), 特定研究, 文部科学省, 1985 - 1985

木村実