論文

査読有り
2018年5月4日

Analyses of the relationship between a ‘number of reflux episodes’ exceeding 70 and the pH index in neurologically impaired children by evaluating esophageal combined pH-multichannel intraluminal impedance measurements

Scandinavian Journal of Gastroenterology
  • Suguru Fukahori
  • ,
  • Minoru Yagi
  • ,
  • Shinji Ishii
  • ,
  • Kimio Asagiri
  • ,
  • Nobuyuki Saikusa
  • ,
  • Naoki Hashizume
  • ,
  • Motomu Yoshida
  • ,
  • Daisuke Masui
  • ,
  • Naruki Higashidate
  • ,
  • Saki Sakamoto
  • ,
  • Hirotomo Nakahara
  • ,
  • Yoshiaki Tanaka

53
5
開始ページ
519
終了ページ
526
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/00365521.2017.1393558
出版者・発行元
Taylor and Francis Ltd

Background: The present study aimed to evaluate the characteristics associated with a number of reflux episodes (NoRE) of 70 by comparing the clinical and multichannel intraluminal impedance pH measurements (pH/MII) and pH index (pHI) in neurologically impaired (NI) children. Patients and methods: NI children (1–16 years of age) in whom pH/MII had been measured for GERD study were enrolled in this study. All children were divided into NoRE &gt
70 or ≤70 and pHI &gt
4.0 or ≤4.0, &gt
5.0 or ≤5.0 or &gt
7.0 or ≤7.0. In addition, the NI children with pHI &gt
4.0, &gt
5.0 and &gt
7.0 were subdivided into NoRE &gt
70 and ≤70 groups. The clinical and pH/MII measurements were compared between each of the two groups. The cutoff values of pHI and baseline impedance (BI) (Z6) were calculated to discriminate NoRE &gt
70 and ≤70. Results: A total of 61 NI children were enrolled in this study. There was a significant difference in the acid-related parameters, the NoRE (nonacid) and BI between NoRE &gt
70 and ≤70, acid-related parameters and BI between pHI &gt
4.0 and ≤4.0, &gt
5.0 and ≤5.0 and &gt
7.0 and ≤7.0 groups. Furthermore, a significant difference was still observed in the BI between NoRE &gt
70 and ≤70 groups among patients with pHI &gt
4.0, &gt
5.0 or &gt
7.0. The cutoff values of pHI and BI (Z6) for discriminating NoRE &gt
70 and ≤70 were 9.2 and 1049Ω, respectively. Conclusion: The present study indicates that NoRE 70 corresponds to GERD in which patients suffer severe acid exposure with pH of around 9% and esophageal mucosal damage with low BI value in NI children.

リンク情報
DOI
https://doi.org/10.1080/00365521.2017.1393558
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29069993

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