Misako Nakayama

Profile Information

Affiliation: Postdoctoral researcher with an EU MCSA fellowship, Institute of Lung Health and Immunity, Helmholtz Center Munich

J-GLOBAL ID: 200901058134562567
researchmap Member ID: 6000018197

External link: https://www.helmholtz-munich.de/en/lhi

Research Interests

Research Areas

Research History

Sep, 2023 - Present

Postdoctoral researcher with an EU MCSA fellowship, Institute of Lung Health and Immunity, Helmholtz Center Munich
Dec, 2008 - Aug, 2023

Assistant Professor, Department of Pathology, Shiga University of Medical Science
Nov, 2017 - Mar, 2019

Guest Scientist, Comprehensive Pneumology Center, Helmholtz Center Munich
Jan, 2017 - May, 2017

Parental Leave
Jan, 2011 - May, 2011

Parental Leave
Apr, 2008 - Nov, 2008

Medical Staff, Department of Pathology, Shiga University of Medical Science
Apr, 2006 - Mar, 2008

Clinical Training, Hikone Municipal Hospital

Education

Apr, 2009 - Mar, 2014

Faculty of Medicine, PhD course, Shiga University of Medical Science
Apr, 2000 - Mar, 2006

Faculty of Medicine, Shiga University of Medical Science
Mar, 2005 - Apr, 2005

Medical Oncology, St George's University of London

Awards

Oct, 2014

Best Research Prize for Women Investigators, Shiga University of Medical Science

NAKAYAMA Misako
Apr, 2014

Pathology Research Prize for Young Investigators, Japanese Society of Pathology

NAKAYAMA Misako

Major Papers

SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates

Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh …

Journal of Neuroimmunology, 578288-578288, Jan, 2024 Peer-reviewed
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

Eri Kawakami, Norikazu Saiki, Yosuke Yoneyama, Chiharu Moriya, Mari Maezawa, Shuntaro Kawamura, Akiko Kinebuchi, Tamaki Kono, Masaaki Funata, Ayaka Sakoda …

Cell stem cell, 30(10) 1315-1330, Oct 5, 2023
Antiviral CD8+ T-cell immune responses are impaired by cigarette smoke and in COPD.

Jie Chen, Xinyuan Wang, Adrian Schmalen, Sophia Haines, Martin Wolff, Huan Ma, Huabin Zhang, Mircea Gabriel Stoleriu, Johannes Nowak, Misako Nakayama …

The European respiratory journal, 62(2), Aug, 2023 Peer-reviewed
134

Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection.

Misako Nakayama, Hannah Marchi, Anna M Dmitrieva, Ashesh Chakraborty, Juliane Merl-Pham, Elisabeth Hennen, Ronan Le Gleut, Clemens Ruppert, Andreas Guenther, Kathrin Kahnert …

Frontiers in microbiology, 13 957830-957830, Jan, 2023 Peer-reviewedLead author
An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants

Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda …

Frontiers in Microbiology, 13 967019-967019, Nov 18, 2022 Peer-reviewedLead author
Lectin Staining to Detect Human and Avian Influenza Virus Receptors in the Airway of Nonhuman Primates.

Misako Nakayama, Yasushi Itoh

Methods in molecular biology (Clifton, N.J.), 2556 37-43, 2022 Lead author
Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

Hirohito Ishigaki, Misako Nakayama, Yoshinori Kitagawa, Cong Thanh Nguyen, Kaori Hayashi, Masanori Shiohara, Bin Gotoh, Yasushi Itoh

Virology, 554 97-105, Feb, 2021 Peer-reviewed
The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.

Kaori Hayashi, Misako Nakayama, Chizuru Iwatani, Hideaki Tsuchiya, Shinichiro Nakamura, Kosuke Nonoguchi, Yasushi Itoh, Shunichiro Tsuji, Hirohito Ishigaki, Takahide Mori …

The Tohoku journal of experimental medicine, 251(4) 241-253, Aug, 2020 Peer-reviewedCorresponding author
Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus

Misako Nakayama, Yasushi Itoh, Shintaro Shichinohe, Rumi Nakabayashi, Hirohito Ishigaki, Yoshihiro Sakoda, Quynh Mai Le, Yoshihiro Kawaoka, Hiroshi Kida, Kazumasa Ogasawara

VACCINE, 35(7) 1008-1017, Feb, 2017 Peer-reviewedLead author
Vaccination against H9N2 avian influenza virus reduces bronchus-associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection

Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida …

PATHOLOGY INTERNATIONAL, 66(12) 678-686, Dec, 2016 Peer-reviewedLead author
Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine

Misako Nakayama, Shintaro Shichinohe, Yasushi Itoh, Hirohito Ishigaki, Mitsutaka Kitano, Masahiko Arikata, Van Loi Pham, Hideaki Ishida, Naoko Kitagawa, Masatoshi Okamatsu …

PLOS ONE, 8(12) e82740, Dec, 2013 Lead author
Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques

Van Loi Pham, Misako Nakayama, Yasushi Itoh, Hirohito Ishigaki, Mitsutaka Kitano, Masahiko Arikata, Hideaki Ishida, Naoko Kitagawa, Shintaro Shichinohe, Masatoshi Okamatsu …

PLOS ONE, 8(9) e75910, Sep, 2013 Lead author

Major Misc.

「感染・免疫研究の新潮流」非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態

清水志乃, 仲山美沙子, 石垣宏仁, Nguyen Thanh Cong, 北川善紀, 伊藤靖, 清水猛史

日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 3回 84-84, Mar, 2023 Peer-reviewed
Long-term efficacy of an inactivated whole particle H5N1 virus against H5N1 highly pathogenic avian influenza virus challenge in cynomolgus monkeys

M Nakayama, H Ishigaki, N Thanh Cong, S Suzuki, H Ishida, N Kitagawa, K Ogasawara, Y Itoh

European Respiratory Journal, 60 (suppl 66) 662-662, Dec 1, 2022 Peer-reviewedLead author
Proteomics of fully differentiated bronchial epithelial cells derived from COPD or control shows no significant differences in susceptibility or response to influenza virus infection

Misako Nakayama, Juliane Merl-Pham, Hannah Busen, Anna Dmitrieva, Ashesh Chakraborty, Andrea Schamberger, Clemens Ruppert, Andreas Guenther, Jürgen Behr, Anne Hilgendorff …

European Respiratory Society, 58(suppl 65), Nov, 2021 Peer-reviewedLead author

Major Presentations

102

Expression of avian-type flu receptor is negatively correlated with differentiation in primary human bronchial epithelial cells

Misako Nakayama, Yuri Morikawa, Jun Terai, Takako Sasamura, Yasushi Itoh

European Respiratory Society International Congress 2023, Milan, Italy, Sep 12, 2023
Influenza and SARS-CoV-2 receptors in an airway organoid from patients with chronic lung diseases

Yuri Morikawa, Misako Nakayama, Takako Sasamura, Hirohito Ishigaki, Yasushi Itoh

The 112th annual congress of Japanese Society of Pathology, Apr 15, 2023
Five-year efficacy of an H5N1 inactivated whole virus particle vaccine against pneumonia in monkeys

Misako Nakayama, Naoko Kitagawa, Hirohito Ishigaki, Nguyen Thanh Cong, Hideaki Ishida, Saori Suzuki, Kazumasa Ogasawara, Yasushi Itoh

The 112th annual congress of Japanese Society of Pathology, Apr 13, 2023
The utility of air-liquid interface culture in respiratory virus research

Misako Nakayama

Reiwa science talk, Mar 24, 2023 Invited
An inactivated whole particle H5N1 vaccine confers protective antibody responses for 5 years in cynomolgus monkeys

Misako Nakayama, Naoko Kitagawa, Hirohito Ishigaki, Thanh Cong Nguyen, Saori Suzuki, Hideaki Ishida, Kazumasa Ogasawara, Yasushi Itoh

The 51th Annual Meeting of the Japanese Soceity for Immunology, Dec 8, 2022
サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について

清水志乃, 仲山美沙子, 石垣宏仁, Nguyen Thanh Cong, 北川善紀, 伊藤靖, 清水猛史, 日本鼻科学

Oct, 2022
Long-term efficacy of an inactivated whole particle H5N1 virus against H5N1 highly pathogenic avian influenza virus challenge in cynomolgus monkeys

M. Nakayama, H. Ishigaki, N. Thanh Cong, S. Suzuki, H. Ishida, N. Kitagawa, K. Ogasawara, Y. Itoh

European Respiratory Society International Congress 2022;Barcelona, Spain, Sep 4, 2022
Pathological research of influenza virus in an animal model and organotypic airway

Misako Nakayama

Summer seminar for medical students and young medical doctors organized by the Japanese Society of Pathology, Aug 20, 2022 Invited
日本におけるワクチン開発「霊長類モデルを用いたインフルエンザとCOVID-19のワクチン開発」

伊藤靖, 石垣宏仁, 仲山美沙子, Nguyen Thanh Cong, 北川善紀, 安井文彦, 小原道法, 石井健, 新開大史, 迫田義博, 喜田宏

第69回日本実験動物学会総会（仙台）, May 20, 2022
Influenza virus and SARS-CoV-2 receptors in chronic respiratory disease-derived epithelial cells

The 111th annual congress of Japanese Society of Pathology, Apr 16, 2022
Proteomics of fully differentiated bronchial epithelial cells derived from COPD or control shows no significant differences in susceptibility or response to influenza virus infection

M. Nakayama, J. Merl-Pham, H. Busen, A. Dmitrieva, A. Chakraborty, A. Schamberger, C. Ruppert, A. Guenther, J. Behr, A. Hilgendorff, S. Hauck, H. Adler, C. A. Staab-Weijnitz

European Respiratory Society International Congress 2021, Online, Sep 5, 2021
コロナウイルス感染症の実験モデルと選択「霊長類モデルを用いた新型コロナウイルス研究」

伊藤靖, 石垣宏仁, 仲山美沙子

第68回日本実験動物学会総会, 2021
カニクイザルで自然発症した子宮内膜症の2年間の腹腔鏡観察による評価

林香里, 仲山美沙子, 中村紳一郎, 辻俊一郎, 木村文則, 伊藤靖, 村上節

第42回日本エンドメトリオーシス学会, 2021
SARS-CoV2感染カニクイザルモデルの病態解析

石垣宏仁, 仲山美沙子, 伊藤靖

第110回日本病理学会総会（東京&Web開催）, 2021

Teaching Experience

Oct, 2020 - Present

Pneumology, Lung Pathology (Shiga University of Medical Science, Department of Medicine)
Apr, 2020 - Present

Pathology of disease, Chronic Obstructive and Restrictive Lung diseases and Infectious diseases of the lung (Shiga University of Medical Science)
Apr, 2010 - Sep, 2017

Pathology (Nagahama Institute of Bio-Science and Technology)
Mechanism of Disease, Inflammation and autoimmune diseases (Shiga University of Medical Science, Department of Nursing)
Pathology of diseases, Endocrine Pathology (Shiga University of Medical Science, Department of Medicine)

Professional Memberships

Research Projects

Epithelial-mesenchymal crosstalk in the pathology of influenza virus infection: https://cordis.europa.eu/project/id/101107766

Marie Skłodowska-Curie Actions, Postdoctoral Fellowship, European Commission, Sep, 2023 - Aug, 2025

Misako Nakayama
Revealing pathology of COPD exacerbation caused by influenza virus in an in vitro COPD model

The Naito Foundation, Jan, 2020 - Dec, 2022

Misako Nakayama
Elucidation of mechanisms involved in increased severety of influenza virus infection by using in vitro models of asthma and COPD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022

Nakayama Misako
ヒト単球上の潜在型TGF-βの発現調節機構とその発現比率による単球の機能差の解明

科学研究費若手研究(B), 日本学術振興会, 2016 - 2019

仲山美沙子
Grants for overseas study for postdoctoral researchers

The Uehara Memorial Foundation, Jan, 2018 - Dec, 2018

NAKAYAMA Misako
Search for host factors in severe influenza virus infection using a nonhuman primate model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Itoh Yasushi
Grants for overseas study for young academic staffs

Shiga University of Medical Science, Sep, 2017 - Mar, 2018

NAKAYAMA Misako

Industrial Property Rights

特開WO/2022/065445 SARS-CoV-2 NEUTRALIZING ANTIBODY OR FRAGMENT THEREOF

Takeshita M, Takeuchi T, SUZUKI K, Saya H, Takahashi Y, Moriyama S, Fukuyama H, Okamura C, Shirouzu M, Matsumoto T, Kamada K, Itoh Y, Ishigaki H, Nakayama M, Kitagawa Y, Kawaoka Y
特開WO/2022/025029 METHOD FOR IN VITRO PROLIFERATING VIRUS BELONGING TO FAMILY CORONAVIRIDAE, METHOD FOR PRODUCING NEUTRALIZING ANTIBODY TO VIRUS BELONGING TO FAMILY CORONAVIRIDAE, AND METHOD FOR PRODUCING INFECTION MODEL OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2

ITOH Yasushi, ISHIGAKI Hirohito, NAKAYAMA Misako, KITAGAWA Yoshinori
特願2021-193428 細胞補集材及び細胞補集用カラム

Other

病理専門医研修指導医

2019 - Present
Pathologist Certified by the Japanese Society of Pathology

Oct, 2014 - Present
Medical doctor

Apr, 2006 - Present
Cambridge English, Certificate of Proficiency in English (CPE, grade B)

Aug, 2001
Certificate to perform autosies

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Major Misc.

Major Presentations

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

Other

Menu

Coauthors