Hiroyuki Mishima

J-GLOBAL         Last updated: Oct 8, 2019 at 16:16
 
Avatar
Name
Hiroyuki Mishima
Affiliation
Nagasaki University
Section
Department of Human Genetics, Atomic Bomb Disease Instirute
Job title
Assistant Professor
Research funding number
10513319
ORCID ID
0000-0001-5050-2509

Profile

Working on human genetics, especially bioinformatics for disease gene hunting using high-throughput sequencers and public databases. Also working on designing databases for data sharing.

Research Areas

 
 

Academic & Professional Experience

 
Jun 2012
 - 
Today
Assistanst Professor, Nagasaki University Graduate School of Biomedical Sciences
 
May 2003
 - 
Feb 2008
Postdoctoral Research Fellow, University of Iowa
 

Education

 
Apr 1997
 - 
Mar 2001
Graduate School of Dental Medicine, Hokkaido University
 
Apr 1991
 - 
Mar 1997
School of Dentistry, Hokkaido University
 

Published Papers

 
Atypical phenotype without fever in a Japanese family with an autosomal dominant transmission of familial Mediterranean fever due to heterozygous MEFV Thr577Asn mutations.
Endo Y, Koga T, Nakashima M, Mishima H, Yoshiura KI, Kawakami A
Clinical and experimental rheumatology      Sep 2019   [Refereed]
Shibano M, Watanabe A, Takano N, Mishima H, Kinoshita A, Yoshiura KI, Shibahara T
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association   1055665619857650   Jul 2019   [Refereed]
Morimoto Y, Yoshida S, Kinoshita A, Satoh C, Mishima H, Yamaguchi N, Matsuda K, Sakaguchi M, Tanaka T, Komohara Y, Imamura A, Ozawa H, Nakashima M, Kurotaki N, Kishino T, Yoshiura KI, Ono S
Neurology   92(20) e2364-e2374   May 2019   [Refereed]
Taguchi M, Mishima H, Shiozawa Y, Hayashida C, Kinoshita A, Nannya Y, Makishima H, Horai M, Matsuo M, Sato S, Itonaga H, Kato T, Taniguchi H, Imanishi D, Imaizumi Y, Hata T, Takenaka M, Moriuchi Y, Shiraishi Y, Miyano S, Ogawa S, Yoshiura KI, Miyazaki Y
Haematologica      May 2019   [Refereed]
Mishima H, Suzuki H, Doi M, Miyazaki M, Watanabe S, Matsumoto T, Morifuji K, Moriuchi H, Yoshiura KI, Kondoh T, Kosaki K
Journal of human genetics      May 2019   [Refereed]
Hitomi Shimizu, Satoshi Watanabe, Akira Kinoshita, Hiroyuki Mishima, Gen Nishimura, Hiroyuki Moriuchi, Koh-ichiro Yoshiura, Sumito Dateki
Journal of Human Genetics   64 467-471   Feb 2019   [Refereed]
Sumito Dateki, Satoshi Watanabe, Hiroyuki Mishima, Toshihiko Shirakawa, Minoru Morikawa, Eiichi Kinoshita, Koh-ichiro Yoshiura, Hiroyuki Moriuchi
Journal of Human Genetics   64 341-346   Jan 2019   [Refereed]
Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI, Yoshiura KI, Kaisho T, Sonoki T, Tamura S
International journal of hematology      Jan 2019   [Refereed]
Hidaka H, Higashimoto K, Aoki S, Mishima H, Hayashida C, Maeda T, Koga Y, Yatsuki H, Joh K, Noshiro H, Iwakiri R, Kawaguchi A, Yoshiura KI, Fujimoto K, Soejima H
Clinical epigenetics   10(1) 150   Dec 2018   [Refereed]
Matsuno S, Furuta H, Kosaka K, Doi A, Yorifuji T, Fukuda T, Senmaru T, Uraki S, Matsutani N, Furuta M, Mishima H, Iwakura H, Nishi M, Yoshiura K, Fukui M, Akamizu T
Journal of diabetes investigation      Nov 2018   [Refereed]
Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S
Translational psychiatry   8(1) 41   Feb 2018   [Refereed]
Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y
International journal of hematology   108(2) 213-217   Feb 2018   [Refereed]
Kikuiri T, Mishima H,Imura H, Suzuki S,Matsuzawa Y, NakamuraT, Fukumoto S, Yoshimura Y, Watanabe S, Kinoshita A, Yamada T, Shindoh M, Sugita Y, Maeda H, Yawaka Y, Mikoya T, Natsume N, Yoshiura K-i
American Journal of Medical Genetics Part A      Dec 2018   [Refereed]
Horai M, Mishima H, Hayashida C, Kinoshita A, Nakane Y, Matsuo T, Tsuruda K, Yanagihara K, Sato S, Imanishi D, Imaizumi Y, Hata T, Miyazaki Y, Yoshiura KI
Journal of human genetics      Dec 2017   [Refereed]
Chisei Satoh, Ryuta Maekawa, Akira Kinoshita, Hiroyuki Mishima, Michiko Doi, Mutsuko Miyazaki, Masafumi Fukuda, Haruo Takahashi, Tatsuro Kondoh, Koh-ichiro Yoshiura
Human Genome Variation   4 17045   Nov 2017   [Refereed]
Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, Nishii K, Saito K, Urano M, Ohno S, Otsuki S, Kimoto H, Baruteau AE, Thollet A, Fouchard S, Bonnaud S, Parent P, Shibata Y, Perrin JP, Le Marec H, Hagiwara N, Mercier S, Horie M, Probst V, Yoshiura KI, Redon R, Schott JJ, Makita N
Journal of the American College of Cardiology   70(3) 358-370   Jul 2017   [Refereed]
Oshima Y, Yamamoto T, Ishikawa T, Mishima H, Matsusue A, Umehara T, Murase T, Abe Y, Kubo SI, Yoshiura KI, Makita N, Ikematsu K
Journal of human genetics      Jul 2017   [Refereed]
Morimoto Y, Ono S, Imamura A, Okazaki Y, Kinoshita A, Mishima H, Nakane H, Ozawa H, Yoshiura KI, Kurotaki N
Human genome variation   4 17032   Jul 2017   [Refereed]
Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A
The Journal of dermatology   44(6) 644-650   Jun 2017   [Refereed]
Taisuke Ishikawa, Seiko Ohno, Takashi Murakami, Kentaro Yoshida, Hiroyuki Mishima, Tetsuya Fukuoka, Hiroki Kimoto, Risa Sakamoto, Takafumi Ohkusa, Takeshi Aiba, Akihiko Nogami, Naokata Sumitomo, Wataru Shimizu, Koh-ichiro Yoshiura, Hitoshi Horigome, Minoru Horie, Naomasa Makita
Heart Rhythm      Jan 2017   [Refereed]
Kiyonori Miura, Hiroyuki Mishima, Michio Yasunami, Masanori Kaneuchi, Michio Kitajima, Shuhei Abe, Ai Higashijima, Naoki Fuchi, Shoko Miura, Koh-Ichiro Yoshiura, Hideaki Masuzaki
Journal of Human Genetics      Sep 2016   [Refereed]
Uchiyama Y, Nakashima M, Watanabe S, Miyajima M, Taguri M, Miyatake S, Miyake N, Saitsu H, Mishima H, Kinoshita A, Arai H, Yoshiura K, Matsumoto N
Scientific reports   6 22985   Mar 2016   [Refereed]
Yamamoto T, Mishima H, Mizukami H, Fukahori Y, Umehara T, Murase T, Kobayashi M, Mori S, Nagai T, Fukunaga T, Yamaguchi S, Yoshiura K, Ikematsu K
Molecular Genetics and Metabolism Reports   5 26-32   Dec 2015   [Refereed]
Tamura S, Higuchi K, Tamaki M, Inoue C, Awazawa R, Mitsuki N, Nakazawa Y, Mishima H, Takahashi K, Kondo O, Imai K, Morio T, Ohara O, Ogi T, Furukawa F, Inoue M, Yoshiura K, Kanazawa N
Clinical immunology (Orlando, Fla.)   160(2) 255-260   Oct 2015   [Refereed]
Tomoshige K, Matsumoto K, Tsuchiya T, Oikawa M, Miyazaki T, Yamasaki N, Mishima H, Kinoshita A, Kubo T, Fukushima K, Yoshiura KI, Nagayasu T
Journal of human genetics      Jul 2015   [Refereed]
Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura KI, Masuzaki H
Fertility and sterility      Mar 2015   [Refereed]
Miura K, Mishima H, Kinoshita A, Hayashida C, Abe S, Tokunaga K, Masuzaki H, Yoshiura K
Journal of medical virology   86 1153-1158   Jul 2014   [Refereed]
Tsukamoto O, Miura K, Mishima H, Abe S, Kaneuchi M, Higashijima A, Miura S, Kinoshita A, Yoshiura K, Masuzaki H
Gynecologic oncology   132 715-721   Mar 2014   [Refereed]
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H
Journal of human genetics      Feb 2014   [Refereed]
Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H
Prenatal diagnosis      Dec 2013   [Refereed]
Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, Miura S, Yamasaki K, Yoshida A, Yoshiura K, Masuzaki H
Prenatal diagnosis   33 214-222   Mar 2013   [Refereed]
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura KI, Masuzaki H
Journal of human genetics   58(5) 250-253   Mar 2013   [Refereed]
Mishima H, Aerts J, Katayama T, Bonnal RJ, Yoshiura KI
BMC bioinformatics   13 240   Sep 2012   [Refereed]
Bonnal RJ, Aerts J, Githinji G, Goto N, MacLean D, Miller CA, Mishima H, Pagani M, Ramirez-Gonzalez R, Smant G, Strozzi F, Syme R, Vos R, Wennblom TJ, Woodcroft BJ, Katayama T, Prins P
Bioinformatics (Oxford, England)   28(7) 1035-1037   Apr 2012   [Refereed]
Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, Takahashi Y, Ohyama K, Ito K, Mishima H, Nomura M, Kinoshita A, Ono S, Takenaka K, Masuyama R, Kudo T, Slor H, Utani A, Tateishi S, Yamashita S, Stefanini M, Lehmann AR, Yoshiura K, Ogi T
Nature genetics   44 586-592   2012   [Refereed]
Mishima H, Sasaki K, Tanaka M, Tatebe O, Yoshiura K
BMC research notes   4 331   Sep 2011   [Refereed]
Arima K, Kinoshita A, Mishima H, Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A, Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, Mimori T, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A, Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, Yoshiura K
Proceedings of the National Academy of Sciences of the United States of America   108(36) 14914-14919   Sep 2011   [Refereed]
Kurotaki N, Tasaki S, Mishima H, Ono S, Imamura A, Kikuchi T, Nishida N, Tokunaga K, Yoshiura K, Ozawa H
PloS one   6 e20589   2011   [Refereed]
Sasaki K, Okamoto N, Kosaki K, Yorifuji T, Shimokawa O, Mishima H, Yoshiura KI, Harada N
Clinical genetics   80(5) 478-483   Dec 2010   [Refereed]
Mishima H, Lidral AC, Ni J
BMC bioinformatics   9 Suppl 6 S10   May 2008   [Refereed]

Books etc

 
Igaku no Ayumi
Hiroyuki Mishima (Part:Contributor, Information Processing in whole exome analyses)
Ishiyaku Pablishers   May 2013   

Conference Activities & Talks

 
Evaluation of Face2Gene using facial images of patients with congenital dysmorphic syndromes recruited in Japan [Invited]
Hiroyuki Mishima
30th Fukuoka International Symposium on Pediatric/Maternal-Child Health Research   31 Aug 2019   
Detection of genomic structural variations in monozygotic twins using Nanopore long-read sequencing technology
Hiroyuki Mishima, Shintaro Yoshida, Yoshiro Morimoto, Shinji Ono, Akira Kinoshita, Akira Imamura, Hiroki Ozawa, Koh-ichiro Yoshiura
13 Jan 2019   
患者顔貌画像による先天性形態異常症候群診断補助システムFace2Geneの本邦症例を用いた性能評価
日本小児学会長崎地方会   16 Dec 2018   
Building and Application of AMED's Genomic Variation Database. [Invited]
Hiroyuki Mishima
NBDC/DBCLS BioHackathon 2017 Symposium   10 Sep 2017   
(Mon(2)-P-109) Bio-Virtuoso: A package of Docker containers for multiple source data retrieval, RDF conversion, and triplesore deployment in a simplified manner.
Hiroyuki Mishima
The 13th International Congress of Human Genetics   2 Apr 2016   

Works

 
Hiroyuki Mishima   Software   Apr 2011 - Today

Research Grants & Projects

 
Japan Society for Promotion of Sciences: KAKENHI (KIBAN (C))
Project Year: Apr 2018 - Mar 2021    Investigator(s): Hiroyuki Mishima
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Hiroyuki MISHIMA
We hypothesized that the genomic structural variation of the defensin genes affects the individual variation of the cervical cancer susceptibility. Two groups, 200 patients with cervical cancer with persistent HPV infection and 200 control pregnan...