2017年
How autophagy eats large mitochondria: Autophagosome formation coupled with mitochondrial fragmentation
AUTOPHAGY
- ,
- 巻
- 13
- 号
- 5
- 開始ページ
- 980
- 終了ページ
- 981
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1080/15548627.2017.1291113
- 出版者・発行元
- TAYLOR & FRANCIS INC
Mitochondrial autophagy (mitophagy) is thought to be a multi-step pathway wherein mitochondria are first divided into small fragments, which are subsequently recognized by the phagophore. DNM1L (dynamin 1 like) plays a pivotal role in mitochondrial division; however, its role in mitophagy remains controversial. In our recent study, we examined the contribution of DNM1L to mitophagy and showed that mitophagy and mitochondrial division occur even in DNM1L-defective cells. Furthermore, time-lapse imaging of mitophagy showed that DNM1L-independent mitochondrial division occurs concomitantly with autophagosome formation. Upstream factors of autophagosome formation, i.e., RB1CC1/FIP200, ATG14, and WIPIs, are required for mitochondrial division, whereas ATG5 and ATG3 are dispensable. These results indicate that a portion of the tubular mitochondria is first recognized and then divided into small fragments by a phagophore-mediated event, independently of DNM1L. This autophagic process suggests that autophagy has the potential to degrade substrates larger than autophagosomes.
- リンク情報
- ID情報
-
- DOI : 10.1080/15548627.2017.1291113
- ISSN : 1554-8627
- eISSN : 1554-8635
- PubMed ID : 28521613
- Web of Science ID : WOS:000401707200019