三苫純也 (Junya Mitoma) - マイポータル

基本情報

所属: 九州医療科学大学生命医科学部教授 (がん細胞研究所長)

学位: 博士（理学）(九州大学)

J-GLOBAL ID: 201601012192644188
researchmap会員ID: B000251152

外部リンク: https://kaken.nii.ac.jp/d/r/10281627.ja.html

研究キーワード

研究分野

経歴

2015年4月 - 現在

九州保健福祉大学, 生命医科学部生命医科学科, 教授
2008年 - 2010年

東北薬科大学, 薬学部, 講師

論文

Vascular E-selectin Expression Detected in Formalin-fixed, Paraffin-embedded Sections With an E-selectin Monoclonal Antibody Correlates With Ulcerative Colitis Activity.

Masataka Murahashi, Akiya Kogami, Akifumi Muramoto, Hitomi Hoshino, Tomoya O Akama, Junya Mitoma, Takanori Goi, Atsuhiro Hirayama, Takuma Okamura, Tadanobu Nagaya …

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 70(4) 299-310 2022年4月
The Conspicuousness of High Endothelial Venules in Angioimmunoblastic T-cell Lymphoma Is Due to Increased Cross-sectional Area, Not Increased Distribution Density.

Akiya Kogami, Mana Fukushima, Hitomi Hoshino, Takuya Komeno, Tadakazu Okoshi, Masataka Murahashi, Tomoya O Akama, Junya Mitoma, Haruo Ohtani, Motohiro Kobayashi

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 69(10) 645-657 2021年10月
Close association of B2 bradykinin receptors with P2Y₂ ATP receptors

Yashima Sayo, Shimazaki Ayaka, Mitoma Junya

The journal of biochemistry 158(2) 155-163 2015年8月査読有り
Close association of B2 bradykinin receptors with P2Y(2) ATP receptors

Sayo Yashima, Ayaka Shimazaki, Junya Mitoma, Tetsuto Nakagawa, Maya Abe, Hiroyuki Yamada, Hideyoshi Higashi

JOURNAL OF BIOCHEMISTRY 158(2) 155-163 2015年8月査読有り
Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation: IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING.

Gu W, Fukuda T, Isaji T, Hang Q, Lee HH, Sakai S, Morise J, Mitoma J, Higashi H, Taniguchi N …

The Journal of biological chemistry 290(28) 17566-17575 2015年7月査読有り
Gangliosides stimulate bradykinin B2 receptors to promote calmodulin kinase Ⅱ-mediated neuronal differentiation

Kanatsu Yoshinori, Chen Nai Hong, Mitoma Junya, NAKAGAWA Tetsuto, HIRABAYASHI Yoshio, HIGASHI Hideyoshi

The journal of biochemistry 152(1) 63-72 2012年7月
ガングリオシドによるB2ブラジキニン受容体の不応化

嶋崎彩佳, 中川哲人, 三苫純也, 東秀好

脂質生化学研究 54 53-56 2012年5月
Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

Kohta Takahashi, Junya Mitoma, Masahiro Hosono, Kazuhiro Shiozaki, Chihiro Sato, Kazunori Yamaguchi, Ken Kitajima, Hideyoshi Higashi, Kazuo Nitta, Hiroshi Shima …

JOURNAL OF BIOLOGICAL CHEMISTRY 287(18) 14816-14826 2012年4月査読有り
Gangliosides and chondroitin sulfate desensitize and internalize B2 bradykinin receptors

Ayaka Shimazaki, Tetsuto Nakagawa, Junya Mitoma, Hideyoshi Higashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 420(1) 193-198 2012年3月査読有り
An Integrin alpha 4 beta 7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue

Hitomi Hoshino, Motohiro Kobayashi, Junya Mitoma, Yoshiko Sato, Minoru Fukuda, Jun Nakayama

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 59(6) 572-583 2011年6月
Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma

Motohiro Kobayashi, Junya Mitoma, Hitomi Hoshino, Shin-Yi Yu, Yasuyo Shimojo, Kenichi Suzawa, Kay-Hooi Khoo, Minoru Fukuda, Jun Nakayama

JOURNAL OF PATHOLOGY 224(1) 67-77 2011年5月査読有り
CORE O-GLYCANS REQUIRED FOR LYMPHOCYTE HOMING: GENE KNOCKOUT MICE OF CORE 1 beta 1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE AND CORE 2 N-ACETYLGLUCOSAMINYLTRANSFERASE

Junya Mitoma, Minoru Fukuda

METHODS IN ENZYMOLOGY, VOL 479: FUNCTIONAL GLYCOMICS 479 257-270 2010年査読有り
The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells

Junya Mitoma, Tatsuo Miyazaki, Mark Sutton-Smith, Misa Suzuki, Hideo Saito, Jiunn-Chern Yeh, Takehiro Kawano, Ole Hindsgaul, Peter H. Seeberger, Maria Panico …

GLYCOCONJUGATE JOURNAL 26(5) 511-523 2009年7月査読有り
リンパ球ホーミングにおける修飾糖鎖 (糖鎖情報の独自性と普遍性) -- (細胞間および細胞外の複合糖質の機能)

三苫純也

蛋白質核酸酵素 53(12) 1598-1603 2008年9月
L-セレクチンを介するリンパ球ホーミングに寄与する糖鎖構造

Mitoma Junya

Trends in glycoscience and glycotechnology 19(110) 257-263 2007年11月
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment

Junya Mitoma, Xingfeng Bao, Bronislawa Petryanik, Patrick Schaerli, Jean-Marc Gauguet, Shin-Yi Yu, Hiroto Kawashima, Hideo Saito, Kazuaki Ohtsubo, Jamey D Marth …

Nature Immunology 8(4) 409-418 2007年4月査読有り
Significant decrease in alpha 1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing

Nobuyoshi Hiraoka, Bronislawa Petryniak, Hiroto Kawashima, Junya Mitoma, Tomoya O. Akama, Michiko N. Fukuda, John B. Lowe, Minoru Fukuda

GLYCOBIOLOGY 17(3) 277-293 2007年3月査読有り
Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

Paula V. Cabrera, Maho Amano, Junya Mitoma, Jessica Chan, Jonathan Said, Minoru Fukuda, Linda G. Baum

BLOOD 108(7) 2399-2406 2006年10月査読有り
Cellular and molecular analysis of neural development of glycosyltransferase gene knockout mice

Kiyohiko Angata, Wenjau Lee, Junya Mitoma, Jamey D. Marth, Minoru Fukuda

FUNCTIONAL GLYCOMICS 417 25-+ 2006年査読有り
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules

Hiroto Kawashima, Bronislawa Petryniak, Nobuyoshi Hiraoka, Junya Mitoma, Valerie Huckaby, Jun Nakayama, Kenji Uchimura, Kenji Kadomatsu, Takashi Muramatsu, John B. Lowe …

Nature Immunology 6(11) 1096-1104 2005年11月査読有り

もっとみる

MISC

O-Glycans Carrying Non-Sulfated Sialyl Lewis X Appearing on HEV-Like Vessels in Gastric MALT Lymphoma Function as L-Selectin Ligands

Motohiro Kobayashi, Junya Mitoma, Hitomi Hoshino, Shin-Yi Yu, Kay-Hooi Khoo, Minoru Fukuda, Jun Nakayama

GLYCOBIOLOGY 20(11) 1490-1490 2010年11月
The HECA-452-Positive But MECA-79-Negative Immunohistochemical Profile of HEV-Like Vessels is Characteristic for the Diagnosis of Gastric MALT Lymphoma

Motohiro Kobayashi, Junya Mitoma, Minoru Fukuda, Jun Nakayama

GLYCOBIOLOGY 19(11) 1323-1323 2009年11月
Mucin-type O-linked oligosaccharides are dispensable for lymphocyte homing: Novel roles of N-glycan-based L-selectin ligands

Junya Mitoma, Xingfeng Bao, Bronislawa Petryanik, Jean-Marc Garguet, Patrick Schaevli, Shin Yi, Hiroto Kawashima, Hideo Saito, Kazuaki Ohtsubo, Kay-Hooi Khoo …

GLYCOBIOLOGY 16(11) 1157-1157 2006年11月
Lymphocyte trafficking in mice deficient in MECA-79 antigen: Analysis of core 1 extension enzyme (beta 1,3-N-acetylglucosaminyltransferase-3) knockout mice

JY Mitoma, JM Gauguet, B Petryniak, H Kawashima, P Schaerli, JB Lowe, UH von Andrian, M Fukuda

GLYCOBIOLOGY 15(11) 1199-1199 2005年11月
Extended core 1 O-glycans in lymphocyte trafficking: analysis of mice deficient in core 1 extension enzyme, beta1,3-N-acetylglucosaminyltransferase-3

J Mitoma, JM Gauguet, H Kawashima, B Petryniak, JB Lowe, UH von Andrian, M Fukuda

FASEB JOURNAL 19(4) A871-A871 2005年3月
Roles of extended core 1 O-glycans in lymphocyte trafficking: Analysis of beta1,3-N-acetylglucosaminyltransferase-3 knockout mice

J Mitoma, H Kawashima, M Fukuda

GLYCOBIOLOGY 14(11) 1144-1145 2004年11月
The role of extended core 1 O-glycans in leukocyte trafficking: beta 1,3-N-Acetylglucosaminyltransferase-3 is essential for synthesis of MECA-79 antigen in lymph nodes and plays a role in lymphocyte adhesion to high endothelial venules

J Mitoma, H Kawashima, M Fukuda

FASEB JOURNAL 18(8) C30-C30 2004年5月
Core 2 branching beta 1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing

N Hiraoka, H Kawashima, B Petryniak, J Nakayama, J Mitoma, JD Marth, JB Lowe, M Fukuda

JOURNAL OF BIOLOGICAL CHEMISTRY 279(4) 3058-3067 2004年1月
N-acetylglucosamine-6-O-sulfotransferase-1 and-2 cooperatively control lymphocyte homing through an essential role in sulfation of L-selectin ligand oligosaccharides in high endothelial venules

H Kawashima, N Hiraoka, J Mitoma, B Petryniak, J Nakayama, JB Lowe, K Uchimura, K Kadomatsu, T Muramatsu, M Fukuda

GLYCOBIOLOGY 13(11) 882-882 2003年11月
The role of extended core 1 O-glycans in leukocyte trafficking: b1,3-N-acetylglucosaminyltransferase-3 is essential for synthesis of MECA-79 antigen in lymph nodes and plays a role in lymphocyte adhesion to high endothelial venules

J Mitoma, H Kawashima, M Fukuda

GLYCOBIOLOGY 13(11) 837-837 2003年11月
L-serine as an astrocyte-derived essential factor for CNS neurons: a previously unrecognized role of astrocytes in brain L-serine metabolism

S Furuya, J Mitoma, T Tabata, PM Watanabe, M Kano, Y Hirabayashi

JOURNAL OF NEUROCHEMISTRY 78 107-107 2001年9月
L-Ser is a major astrocyte-derived trophic factor for cerebellar Purkinje neurons.

S Furuya, T Tabata, J Mitoma, M Watanabe, M Kano, Y Hirabayashi

MOLECULAR BIOLOGY OF THE CELL 11 415A-415A 2000年12月
Nonessential amino acids L-serine and glycine are astroglia-derived trophic factors for central neurons.

S Furuya, J Mitoma, T Tabata, M Watanabe, M Kano, Y Hirabayashi

JOURNAL OF NEUROCHEMISTRY 73 S178-S178 1999年

共同研究・競争的資金等の研究課題

個体の大きさに関与するGタンパク共役型受容体のリガンド探索とその作用

日本学術振興会科学研究費助成事業基盤研究(C) 2008年 - 2010年

三苫純也
L−セリンを介する神経細胞とアストロサイトの代謝的相互作用の解析

日本学術振興会科学研究費助成事業奨励研究(A) 1999年 - 1999年

三苫純也
スフィンゴ脂質による細胞膜の極性形成と生物機能発現機構の解析

日本学術振興会科学研究費助成事業基盤研究(B) 1997年 - 1999年

平林義雄, 入江史敏, 市川進一, 古屋茂樹, 三苫純也, 金森容子
グリア細胞由来の神経細胞の生存に関わる新たな因子の発見とその作用機構の解析

日本学術振興会科学研究費助成事業奨励研究(A) 1997年 - 1998年

三苫純也

三苫純也

基本情報

研究キーワード

研究分野

経歴

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

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