Junya Mitoma

Profile Information

Affiliation: Professor, Kyushu University of Medical Science

Degree: 博士（理学）(九州大学)

J-GLOBAL ID: 201601012192644188
researchmap Member ID: B000251152

External link: https://kaken.nii.ac.jp/d/r/10281627.ja.html

Research Interests

Research Areas

Research History

Apr, 2015 - Present

Professor, School of Medical Life Sciences Department of Medical Life Sciences, Kyushu University of Health and Welfare
2008 - 2010

講師, 薬学部, 東北薬科大学

Papers

Vascular E-selectin Expression Detected in Formalin-fixed, Paraffin-embedded Sections With an E-selectin Monoclonal Antibody Correlates With Ulcerative Colitis Activity.

Masataka Murahashi, Akiya Kogami, Akifumi Muramoto, Hitomi Hoshino, Tomoya O Akama, Junya Mitoma, Takanori Goi, Atsuhiro Hirayama, Takuma Okamura, Tadanobu Nagaya …

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 70(4) 299-310, Apr, 2022
The Conspicuousness of High Endothelial Venules in Angioimmunoblastic T-cell Lymphoma Is Due to Increased Cross-sectional Area, Not Increased Distribution Density.

Akiya Kogami, Mana Fukushima, Hitomi Hoshino, Takuya Komeno, Tadakazu Okoshi, Masataka Murahashi, Tomoya O Akama, Junya Mitoma, Haruo Ohtani, Motohiro Kobayashi

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 69(10) 645-657, Oct, 2021
Close association of B2 bradykinin receptors with P2Y(2) ATP receptors

Sayo Yashima, Ayaka Shimazaki, Junya Mitoma, Tetsuto Nakagawa, Maya Abe, Hiroyuki Yamada, Hideyoshi Higashi

JOURNAL OF BIOCHEMISTRY, 158(2) 155-163, Aug, 2015 Peer-reviewed
Close association of B2 bradykinin receptors with P2Y(2) ATP receptors

Sayo Yashima, Ayaka Shimazaki, Junya Mitoma, Tetsuto Nakagawa, Maya Abe, Hiroyuki Yamada, Hideyoshi Higashi

JOURNAL OF BIOCHEMISTRY, 158(2) 155-163, Aug, 2015 Peer-reviewed
Loss of alpha 1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING

Wei Gu, Tomohiko Fukuda, Tomoya Isaji, Qinglei Hang, Ho-hsun Lee, Seiichiro Sakai, Jyoji Morise, Junya Mitoma, Hideyoshi Higashi, Naoyuki Taniguchi …

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(28) 17566-17575, Jul, 2015 Peer-reviewed
Gangliosides stimulate bradykinin B2 receptors to promote calmodulin kinase II-mediated neuronal differentiation

Yoshinori Kanatsu, Nai Hong Chen, Junya Mitoma, Tetsuto Nakagawa, Yoshio Hirabayashi, Hideyoshi Higashi

JOURNAL OF BIOCHEMISTRY, 152(1) 63-72, Jul, 2012
ガングリオシドによるB2ブラジキニン受容体の不応化

嶋崎彩佳, 中川哲人, 三苫純也, 東秀好

脂質生化学研究, 54 53-56, May, 2012
Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons

Kohta Takahashi, Junya Mitoma, Masahiro Hosono, Kazuhiro Shiozaki, Chihiro Sato, Kazunori Yamaguchi, Ken Kitajima, Hideyoshi Higashi, Kazuo Nitta, Hiroshi Shima …

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(18) 14816-14826, Apr, 2012 Peer-reviewed
Gangliosides and chondroitin sulfate desensitize and internalize B2 bradykinin receptors

Ayaka Shimazaki, Tetsuto Nakagawa, Junya Mitoma, Hideyoshi Higashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 420(1) 193-198, Mar, 2012 Peer-reviewed
An Integrin alpha 4 beta 7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue

Hitomi Hoshino, Motohiro Kobayashi, Junya Mitoma, Yoshiko Sato, Minoru Fukuda, Jun Nakayama

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 59(6) 572-583, Jun, 2011
Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma

Motohiro Kobayashi, Junya Mitoma, Hitomi Hoshino, Shin-Yi Yu, Yasuyo Shimojo, Kenichi Suzawa, Kay-Hooi Khoo, Minoru Fukuda, Jun Nakayama

JOURNAL OF PATHOLOGY, 224(1) 67-77, May, 2011 Peer-reviewed
CORE O-GLYCANS REQUIRED FOR LYMPHOCYTE HOMING: GENE KNOCKOUT MICE OF CORE 1 beta 1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE AND CORE 2 N-ACETYLGLUCOSAMINYLTRANSFERASE

Junya Mitoma, Minoru Fukuda

METHODS IN ENZYMOLOGY, VOL 479: FUNCTIONAL GLYCOMICS, 479 257-270, 2010 Peer-reviewed
The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells

Junya Mitoma, Tatsuo Miyazaki, Mark Sutton-Smith, Misa Suzuki, Hideo Saito, Jiunn-Chern Yeh, Takehiro Kawano, Ole Hindsgaul, Peter H. Seeberger, Maria Panico …

GLYCOCONJUGATE JOURNAL, 26(5) 511-523, Jul, 2009 Peer-reviewed
Oligosaccharides in lymphocyte homing

三苫純也

Protein, nucleic acid and enzyme, 53(12) 1598-1603, Sep, 2008
Structural basis of oligosaccharides for L-selectin-mediated lymphocyte homing

Junya Mitoma

Trends in Glycoscience and Glycotechnology, 19(110) 257-263, Nov, 2007
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment.

Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD …

Nature immunology, 8(4) 409-418, Apr, 2007 Peer-reviewed
Significant decrease in alpha 1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing

Nobuyoshi Hiraoka, Bronislawa Petryniak, Hiroto Kawashima, Junya Mitoma, Tomoya O. Akama, Michiko N. Fukuda, John B. Lowe, Minoru Fukuda

GLYCOBIOLOGY, 17(3) 277-293, Mar, 2007 Peer-reviewed
Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

Paula V. Cabrera, Maho Amano, Junya Mitoma, Jessica Chan, Jonathan Said, Minoru Fukuda, Linda G. Baum

BLOOD, 108(7) 2399-2406, Oct, 2006 Peer-reviewed
Cellular and molecular analysis of neural development of glycosyltransferase gene knockout mice

Kiyohiko Angata, Wenjau Lee, Junya Mitoma, Jamey D. Marth, Minoru Fukuda

FUNCTIONAL GLYCOMICS, 417 25-+, 2006 Peer-reviewed
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules

Hiroto Kawashima, Bronislawa Petryniak, Nobuyoshi Hiraoka, Junya Mitoma, Valerie Huckaby, Jun Nakayama, Kenji Uchimura, Kenji Kadomatsu, Takashi Muramatsu, John B. Lowe …

Nature Immunology, 6(11) 1096-1104, Nov, 2005 Peer-reviewed

Misc.

O-Glycans Carrying Non-Sulfated Sialyl Lewis X Appearing on HEV-Like Vessels in Gastric MALT Lymphoma Function as L-Selectin Ligands

Motohiro Kobayashi, Junya Mitoma, Hitomi Hoshino, Shin-Yi Yu, Kay-Hooi Khoo, Minoru Fukuda, Jun Nakayama

GLYCOBIOLOGY, 20(11) 1490-1490, Nov, 2010
The HECA-452-Positive But MECA-79-Negative Immunohistochemical Profile of HEV-Like Vessels is Characteristic for the Diagnosis of Gastric MALT Lymphoma

Motohiro Kobayashi, Junya Mitoma, Minoru Fukuda, Jun Nakayama

GLYCOBIOLOGY, 19(11) 1323-1323, Nov, 2009
Mucin-type O-linked oligosaccharides are dispensable for lymphocyte homing: Novel roles of N-glycan-based L-selectin ligands

Junya Mitoma, Xingfeng Bao, Bronislawa Petryanik, Jean-Marc Garguet, Patrick Schaevli, Shin Yi, Hiroto Kawashima, Hideo Saito, Kazuaki Ohtsubo, Kay-Hooi Khoo …

GLYCOBIOLOGY, 16(11) 1157-1157, Nov, 2006
Lymphocyte trafficking in mice deficient in MECA-79 antigen: Analysis of core 1 extension enzyme (beta 1,3-N-acetylglucosaminyltransferase-3) knockout mice

JY Mitoma, JM Gauguet, B Petryniak, H Kawashima, P Schaerli, JB Lowe, UH von Andrian, M Fukuda

GLYCOBIOLOGY, 15(11) 1199-1199, Nov, 2005
Extended core 1 O-glycans in lymphocyte trafficking: analysis of mice deficient in core 1 extension enzyme, beta1,3-N-acetylglucosaminyltransferase-3

J Mitoma, JM Gauguet, H Kawashima, B Petryniak, JB Lowe, UH von Andrian, M Fukuda

FASEB JOURNAL, 19(4) A871-A871, Mar, 2005
Roles of extended core 1 O-glycans in lymphocyte trafficking: Analysis of beta1,3-N-acetylglucosaminyltransferase-3 knockout mice

J Mitoma, H Kawashima, M Fukuda

GLYCOBIOLOGY, 14(11) 1144-1145, Nov, 2004
The role of extended core 1 O-glycans in leukocyte trafficking: beta 1,3-N-Acetylglucosaminyltransferase-3 is essential for synthesis of MECA-79 antigen in lymph nodes and plays a role in lymphocyte adhesion to high endothelial venules

J Mitoma, H Kawashima, M Fukuda

FASEB JOURNAL, 18(8) C30-C30, May, 2004
Core 2 branching beta 1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing

N Hiraoka, H Kawashima, B Petryniak, J Nakayama, J Mitoma, JD Marth, JB Lowe, M Fukuda

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(4) 3058-3067, Jan, 2004
N-acetylglucosamine-6-O-sulfotransferase-1 and-2 cooperatively control lymphocyte homing through an essential role in sulfation of L-selectin ligand oligosaccharides in high endothelial venules

H Kawashima, N Hiraoka, J Mitoma, B Petryniak, J Nakayama, JB Lowe, K Uchimura, K Kadomatsu, T Muramatsu, M Fukuda

GLYCOBIOLOGY, 13(11) 882-882, Nov, 2003
The role of extended core 1 O-glycans in leukocyte trafficking: b1,3-N-acetylglucosaminyltransferase-3 is essential for synthesis of MECA-79 antigen in lymph nodes and plays a role in lymphocyte adhesion to high endothelial venules

J Mitoma, H Kawashima, M Fukuda

GLYCOBIOLOGY, 13(11) 837-837, Nov, 2003
L-serine as an astrocyte-derived essential factor for CNS neurons: a previously unrecognized role of astrocytes in brain L-serine metabolism

S Furuya, J Mitoma, T Tabata, PM Watanabe, M Kano, Y Hirabayashi

JOURNAL OF NEUROCHEMISTRY, 78 107-107, Sep, 2001
L-Ser is a major astrocyte-derived trophic factor for cerebellar Purkinje neurons.

S Furuya, T Tabata, J Mitoma, M Watanabe, M Kano, Y Hirabayashi

MOLECULAR BIOLOGY OF THE CELL, 11 415A-415A, Dec, 2000
Nonessential amino acids L-serine and glycine are astroglia-derived trophic factors for central neurons.

S Furuya, J Mitoma, T Tabata, M Watanabe, M Kano, Y Hirabayashi

JOURNAL OF NEUROCHEMISTRY, 73 S178-S178, 1999

Research Projects

Studies on orphan G protein-coupled receptors which are related to body size : ligand search and their functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

MITOMA Junya
L−セリンを介する神経細胞とアストロサイトの代謝的相互作用の解析

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1999 - 1999

三苫純也
Molecular characterization of membrane sphingolipid function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1999

HIRABAYASHI Yoshio, IRIE Fumitoshi, ICHIKAWA Shinichi, FURUYA Shigeki
グリア細胞由来の神経細胞の生存に関わる新たな因子の発見とその作用機構の解析

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1997 - 1998

三苫純也

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