2001年5月
Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus
CLINICAL NEPHROLOGY
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- 巻
- 55
- 号
- 5
- 開始ページ
- 357
- 終了ページ
- 364
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- DUSTRI-VERLAG DR KARL FEISTLE
Aim: We tried to establish the significance of quantifying urinary type IV collagen (W-C) excretion for the evaluation of renal involvement of type 2-diabetic patients. Methods: Twenty patients (13 males and 7 females, age range 31 to 69 years) with type 2 diabetes mellitus had undergone renal biopsy and relationship between the severity of morphological alteration, IV-C expression and urinary IV-C excretion were examined. Results. Urinary IV-C excretion significantly correlated with mesangial expansion score (rho = 0.49, p < 0.05) and tubulointerstitial injury score (rho = 0.56, p < 0.05). Furthermore, urinary IV-C excretion significantly correlated with both glomerular (r = 0.56, p < 0.01) and tubulointerstitial IV-C expression areas. Urinary protein excretion also correlated with mesangial expansion score and tubulointerstitial injury score. However, it did not correlate with the expression of IV-C in the kidney. Conclusions: These results suggest that urinary IV-C excretion reflects the pathogenetic process of diabetic nephropathy, which urinary protein excretion alone cannot do sufficiently. It can be concluded that urinary IV-C excretion could be a more useful marker for the evaluation of renal involvement of type 2-diabetic patients.
- リンク情報
- ID情報
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- ISSN : 0301-0430
- PubMed ID : 11393380
- Web of Science ID : WOS:000172184400003