2016年2月15日
C-C chemokine receptor type 4 antagonist Compound 22 ameliorates experimental autoimmune encephalomyelitis
Journal of Neuroimmunology
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- 巻
- 291
- 号
- 開始ページ
- 54
- 終了ページ
- 58
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jneuroim.2015.12.011
- 出版者・発行元
- ELSEVIER SCIENCE BV
© 2015 Elsevier B.V. Chemokines and chemokine receptors play important roles in the immune response. We previously reported the pathogenic role of C-C chemokine receptor type 4 (CCR4) in experimental autoimmune encephalomyelitis (EAE). Here, we examined whether CCR4 antagonism modulates the disease course of EAE. Wild-type and CCR4-knockout mice were induced EAE and were administered Compound 22, an antagonist of CCR4. Compound 22 significantly ameliorated the severity of EAE in wild-type mice, but not in the CCR4-knockout mice. Compound 22 inhibited Th1 and Th17 polarization of antigen-induced T-cell responses. Therefore, CCR4 antagonists might be potential therapeutic agents for multiple sclerosis.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.jneuroim.2015.12.011
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26857495
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000370906900008&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959358996&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84959358996&origin=inward
- ID情報
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- DOI : 10.1016/j.jneuroim.2015.12.011
- ISSN : 0165-5728
- eISSN : 1872-8421
- PubMed ID : 26857495
- SCOPUS ID : 84959358996
- Web of Science ID : WOS:000370906900008