原田美由紀 (Miyuki Harada) - マイポータル

基本情報

所属: 東京大学大学院医学系研究科産婦人科学

学位: 医学博士(2007年3月東京大学)

研究者番号: 70451812
J-GLOBAL ID: 201801005743539389
researchmap会員ID: B000306237

研究キーワード

研究分野

経歴

2025年7月 - 現在

東京大学大学院医学系研究科, 産婦人科学, 教授
2020年4月 - 2025年7月

東京大学, 産婦人科, 准教授
2016年12月 - 2020年3月

東京大学, 産婦人科, 講師
2009年10月 - 2016年11月

東京大学, 産婦人科, 助教
2008年10月 - 2009年9月

ミシガン大学, 産婦人科/生化学教室, 日本学術振興会若手研究者International Training Program 研究員
2008年5月 - 2008年9月

東京大学, 産婦人科, 助教
2007年4月 - 2008年4月

東京大学, 産婦人科, 医員

学歴

- 2007年3月

東京大学大学院, 医学系研究科, 生殖発達加齢医学専攻
- 2000年3月

東京大学, 医学部, 医学科

主要な委員歴

もっとみる

受賞

2025年6月

2024年度（第27回）神澤医学賞, 多嚢胞性卵巣症候群（PCOS）の謎に迫る―病態解明から新規治療開発、発症予防へ向けた挑戦ー, 公益財団法人神澤医学研究振興財団
2020年9月

第20回日本抗加齢医学会総会最優秀演題賞

原田美由紀
2020年1月

第11回ロート女性健康科学研究賞

原田美由紀
2018年

平成30年度日本女性医学学会学会奨励賞

原田美由紀
2011年

第62回日本産科婦人科学会IS Award

原田美由紀
2005年

第50回日本不妊学会優秀演題賞

原田美由紀

主要な論文

248

12

Assessment and prediction models for the quantitative and qualitative reserve of the ovary using machine learning.

Hiroshi Koike, Miyuki Harada, Kaname Yoshida, Katsuhiko Noda, Chihiro Tsuchida, Toshihiro Fujiwara, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi …

Journal of ovarian research 18(1) 153-153 2025年7月18日査読有り責任著者
8

Trends in fertility preservation treatments in Japan until 2023: analysis of the Japan Oncofertility Registry

Takao Kawai, Miyuki Harada, Yoko Urata, Yuko Sanada, Youtaro Kaneda, Yasushi Takai, Yutaka Osuga, Nao Suzuki

International Journal of Clinical Oncology 30(4) 684-695 2025年2月28日査読有り責任著者
4

Effect of embryo cryopreservation before surgery on clinical outcomes in IVF patients with endometrioma.

Nozomi Takahashi, Yuma Kawahara, Miyuki Harada, Tomoko Makabe, Gentaro Izumi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga

Reproductive medicine and biology 24(1) e12654 2025年
65

Cellular senescence in the pathogenesis of ovarian dysfunction.

Miyuki Harada

The journal of obstetrics and gynaecology research 50(5) 800-808 2024年5月査読有り招待有り筆頭著者責任著者
21

Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome.

Tsurugi Tanaka, Yoko Urata, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Zixin Xu, Nanoka Sakaguchi, Chihiro Tsuchida, Airi Komura …

Molecular human reproduction 2024年4月11日査読有り責任著者
60

The Association between Endometriosis and Obstructive Müllerian Anomalies.

Nozomi Takahashi, Miyuki Harada, Mayuko Kanatani, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga

Biomedicines 12(3) 2024年3月14日査読有り責任著者
65

The prevalence of vulvovaginal symptoms in Japanese women of reproductive and perimenopausal ages: A cross-sectional study across generations.

Takao Kawai, Miyuki Harada, Katsuki Yamada, Rui Ugomori, Yutaka Osuga

The journal of obstetrics and gynaecology research 2024年3月4日査読有り責任著者
21

Lifestyle and fertility-specific quality of life affect reproductive outcomes in couples undergoing in vitro fertilization.

Yoko Urata, Miyuki Harada, Shinnosuke Komiya, Ikumi Akiyama, Chihiro Tuchida, Yoshiharu Nakaoka, Aisaku Fukuda, Yoshiharu Morimoto, Takuya Kawahara, Yusuke Ishikawa …

Frontiers in endocrinology 15 1346084-1346084 2024年査読有り責任著者
14

Effects of the prenatal and postnatal nurturing environment on the phenotype and gut microbiota of mice with polycystic ovary syndrome induced by prenatal androgen exposure: a cross-fostering study.

Akari Kusamoto, Miyuki Harada, Ayaka Minemura, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Nanoka Sakaguchi, Jerilee M K Azhary, Hiroshi Koike, Zixin Xu …

Frontiers in cell and developmental biology 12 1365624-1365624 2024年査読有り責任著者
62

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency.

Zixin Xu, Nozomi Takahashi, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Tsurugi Tanaka, Nanoka Sakaguchi, Yoko Urata, Osamu Wada-Hiraike …

International journal of molecular sciences 24(24) 2023年12月6日査読有り責任著者
49

Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome.

Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Jerilee M K Azhary, Nozomi Takahashi, Yoko Urata …

Frontiers in endocrinology 14 1124405-1124405 2023年査読有り招待有り責任著者
45

Notch Signaling Induced by Endoplasmic Reticulum Stress Regulates Cumulus-Oocyte Complex Expansion in Polycystic Ovary Syndrome.

Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Chisato Kunitomi, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Emi Nose, Nozomi Takahashi, Osamu Wada-Hiraike …

Biomolecules 12(8) 2022年7月27日査読有り責任著者
16

Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1.

Miyuki Harada, Fuminori Kimura, Yasushi Takai, Takeshi Nakajima, Kimio Ushijima, Hiroaki Kobayashi, Toyomi Satoh, Akiko Tozawa, Kohei Sugimoto, Shigehira Saji …

International journal of clinical oncology 27(2) 265-280 2022年2月査読有り筆頭著者
88

Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research.

Miyuki Harada

Reproductive medicine and biology 21(1) e12487 2022年査読有り招待有り筆頭著者責任著者
39

The possible effects of the Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 on the practice of fertility preservation in female cancer patients in Japan.

Chisato Kunitomi, Miyuki Harada, Yuko Sanada, Akari Kusamoto, Yasushi Takai, Tatsuro Furui, Yuko Kitagawa, Mitsutoshi Yamada, Chie Watanabe, Koichiro Tsugawa …

Reproductive medicine and biology 21(1) e12453 2022年査読有り責任著者
210

Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome-like phenotypes in prenatally androgenized female mice.

Kusamoto A, Harada M, Azhary JMK, Kunitomi C, Nose E, Koike H, Xu Z, Urata Y, Kaku T, Takahashi N …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35(11) 2021年11月査読有り責任著者
115

Pregnancy outcomes in children, adolescents, and young adults that survived cancer: A nationwide survey in Japan

Toshiaki Yasuoka, Noriyuki Iwama, Kuniaki Ota, Miyuki Harada, Junichi Hasegawa, Nobuo Yaegashi, Takashi Sugiyama, Nao Suzuki, Yutaka Osuga

Journal of Obstetrics and Gynaecology Research 47(9) 3352-3361 2021年9月査読有り責任著者
230

Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome.

Chisato Kunitomi, Miyuki Harada, Akari Kusamoto, Jerilee Mk Azhary, Emi Nose, Hiroshi Koike, Zixin Xu, Yoko Urata, Nozomi Takahashi, Osamu Wada-Hiraike …

Molecular human reproduction 27(3) 2021年2月27日査読有り責任著者
88

National survey of primary amenorrhea and relevant conditions in Japan

Hirofumi Haraguchi, Miyuki Harada, Kenichi Kashimada, Reiko Horikawa, Hideya Sakakibara, Makio Shozu, Tomoyuki Fujii, Yutaka Osuga, Koji Kugu

Journal of Obstetrics and Gynaecology Research 47(2) 774-777 2021年2月査読有り責任著者
307

Endoplasmic reticulum stress: a key regulator of the follicular microenvironment in the ovary.

Miyuki Harada, Nozomi Takahashi, Jerilee Mk Azhary, Chisato Kunitomi, Tomoyuki Fujii, Yutaka Osuga

Molecular human reproduction 27(1) 2021年1月22日査読有り筆頭著者責任著者
118

Does polycystic ovary syndrome independently affect oncologic and reproductive outcomes in patients with endometrial cancer receiving fertility-sparing treatment?

Miyuki Harada, Yutaka Osuga

Journal of Gynecologic Oncology 32(5) 2021年招待有り筆頭著者
209

Androgens Increase Accumulation of Advanced Glycation End Products in Granulosa Cells by Activating ER Stress in PCOS

Jerilee M K Azhary, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Nozomi Takahashi, Emi Nose, Nagisa Oi, Osamu Wada-Hiraike, Yoko Urata, Tetsuya Hirata …

Endocrinology 161(2) 2020年2月1日査読有り責任著者
216

Preclinical validation of the new vitrification device possessing a feature of absorbing excess vitrification solution for the cryopreservation of human embryos.

Nozomi Takahashi, Miyuki Harada, Nagisa Oi, Gentaro Izumi, Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Tetsuya Hirata, Tomoyuki Fujii, Yutaka Osuga

The journal of obstetrics and gynaecology research 46(2) 302-309 2020年2月査読有り責任著者
Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma.

Chisato Kunitomi, Miyuki Harada, Nozomi Takahashi, Jerilee M K Azhary, Akari Kusamoto, Emi Nose, Nagisa Oi, Arisa Takeuchi, Osamu Wada-Hiraike, Tetsuya Hirata …

Molecular human reproduction 26(1) 40-52 2020年1月1日査読有り責任著者
Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence.

Takahashi N, Harada M, Azhary JMK, Kunitomi C, Nose E, Terao H, Koike H, Wada-Hiraike O, Hirata T, Hirota Y …

Molecular human reproduction 25(11) 684-694 2019年11月30日査読有り責任著者
26

A Japanese nationwide survey on the cryopreservation of embryos, oocytes and ovarian tissue for cancer patients.

Yuko Sanada, Miyuki Harada, Chisato Kunitomi, Mayuko Kanatani, Gentaro Izumi, Tetsuya Hirata, Tomoyuki Fujii, Nao Suzuki, Ken-Ichirou Morishige, Daisuke Aoki …

The journal of obstetrics and gynaecology research 45(10) 2021-2028 2019年10月査読有り責任著者
48

Fertility preservation for female cancer patients.

Miyuki Harada, Yutaka Osuga

International journal of clinical oncology 24(1) 28-33 2019年1月査読有り招待有り筆頭著者
36

Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.

Jerilee M K Azhary, Miyuki Harada, Nozomi Takahashi, Emi Nose, Chisato Kunitomi, Hiroshi Koike, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Osamu Wada-Hiraike …

Endocrinology 160(1) 119-132 2019年1月1日査読有り責任著者
26

Factors associated with successful pregnancy in women of late reproductive age with uterine fibroids who undergo embryo cryopreservation before surgery.

Nozomi Takahashi, Miyuki Harada, Ryosuke Tanabe, Akane Takayanagi, Gentaro Izumi, Nagisa Oi, Tetsuya Hirata, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga

The journal of obstetrics and gynaecology research 44(10) 1956-1962 2018年10月査読有り責任著者
46

Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis.

Nozomi Takahashi, Miyuki Harada, Yasushi Hirota, Emi Nose, Jerilee Mk Azhary, Hiroshi Koike, Chisato Kunitomi, Osamu Yoshino, Gentaro Izumi, Tetsuya Hirata …

Scientific reports 7(1) 10824-10824 2017年9月7日査読有り責任著者
28

A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women.

Nozomi Takahashi, Miyuki Harada, Yasushi Hirota, Lin Zhao, Jerilee M K Azhary, Osamu Yoshino, Gentaro Izumi, Tetsuya Hirata, Kaori Koga, Osamu Wada-Hiraike …

Endocrinology 158(1) 84-97 2017年1月1日査読有り責任著者
16

Where are oncofertility and fertility preservation treatments heading in 2016?

Miyuki Harada, Yutaka Osuga

Future oncology (London, England) 12(20) 2313-21 2016年10月査読有り招待有り筆頭著者
23

A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome.

Nozomi Takahashi, Miyuki Harada, Yasushi Hirota, Lin Zhao, Osamu Yoshino, Yoko Urata, Gentaro Izumi, Masashi Takamura, Tetsuya Hirata, Kaori Koga …

Molecular and cellular endocrinology 428(C) 161-9 2016年6月15日査読有り責任著者
25

Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.

Masakazu Sato, Miyuki Harada, Hajime Oishi, Osamu Wada-Hiraike, Tetsuya Hirata, Kazunori Nagasaka, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga

Journal of lower genital tract disease 20(2) e11-3-e13 2016年4月査読有り責任著者
47

Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation.

Miyuki Harada, Emi Nose, Nozomi Takahashi, Yasushi Hirota, Tetsuya Hirata, Osamu Yoshino, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 31(10) 783-7 2015年10月査読有り筆頭著者責任著者
17

Laparoscopic excision of ovarian endometrioma does not exert a qualitative effect on ovarian function: insights from in vitro fertilization and single embryo transfer cycles.

Miyuki Harada, Nozomi Takahashi, Tetsuya Hirata, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga

Journal of assisted reproduction and genetics 32(5) 685-9 2015年5月査読有り筆頭著者責任著者
Molecular regulation of gonadotropin receptor expression: Relationship to sterol metabolism

K. M. J. Menon, B. Menon, L. Wang, T. Gulappa, M. Harada

MOLECULAR AND CELLULAR ENDOCRINOLOGY 329(1-2) 26-32 2010年11月査読有り
34

Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary

M. Harada, H. Peegel, K. M. J. Menon

MOLECULAR AND CELLULAR ENDOCRINOLOGY 328(1-2) 28-33 2010年10月査読有り筆頭著者
Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells.

Senait Fisseha, Roberto Towns, Miyuki Harada, Helle Peegel, K M J Menon

Endocrine 37(1) 187-93 2010年2月査読有り