Miyuki Harada

Last updated: Jul 17, 2019 at 14:16

Name	Miyuki Harada
Research funding number	70451812

Research Interests

Unfolded Protein Response (UPR)(1) , Endoplasmic Reticulum stress (ER stress)(1) , granulosa cell(2) , PCOS(2) , ovary(20)

Research Areas

Biological Science / Molecular biology /
Laboratory animal science / Laboratory animal science /
Basic medicine / General physiology /
Clinical surgery / Obstetrics and gynecology /

Published Papers

Plain Text1 2 >

Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment.

Terao H, Wada-Hiraike O, Nagumo A, Kunitomi C, Azhary JMK, Harada M, Hirata T, Hirota Y, Koga K, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research Jul 2019 [Refereed]

A new vitrification device that absorbs excess vitrification solution adaptable to a closed system for the cryopreservation of mouse embryos.

Momozawa K, Matsuzawa A, Tokunaga Y, Ohi N, Harada M

Cryobiology 88 9-14 Jun 2019 [Refereed]

Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway.

Takeuchi A, Koga K, Satake E, Makabe T, Taguchi A, Miyashita M, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Wada-Hiraike O, Fujii T, Osuga Y

The Journal of clinical endocrinology and metabolism Jun 2019 [Refereed]

Contralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy.

Hidari T, Hirata T, Arakawa T, Koga K, Neriishi K, Fukuda S, Nakazawa A, Nagashima N, Ma S, Sun H, Takamura M, Harada M, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

BMC women's health 19(1) 59 May 2019 [Refereed]

Risk factors of stress fractures due to the female athlete triad: Differences in teens and twenties.

Nose-Ogura S, Yoshino O, Dohi M, Kigawa M, Harada M, Hiraike O, Onda T, Osuga Y, Fujii T, Saito S

Scandinavian journal of medicine & science in sports May 2019 [Refereed]

Serum Brain-derived Neurotrophic Factor Levels Mirror Bone Mineral Density in Amenorrheic and Eumenorrheic Athletes.

Nose S, Yoshino O, Nomoto K, Harada M, Dohi M, Kawahara T, Osuga Y, Fujii T, Saito S

International journal of sports medicine 40(4) 276-282 Apr 2019 [Refereed]

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary.

Akino N, Wada-Hiraike O, Isono W, Terao H, Honjo H, Miyamoto Y, Tanikawa M, Sone K, Hirano M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Fujii T, Osuga Y

Reproductive biology and endocrinology : RB&E 17(1) 23 Feb 2019 [Refereed]

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis.

Arakawa T, Fukuda S, Hirata T, Neriishi K, Wang Y, Takeuchi A, Saeki A, Harada M, Hirota Y, Matsumoto T, Koga K, Wada-Hiraike O, Kurihara M, Fujii T, Osuga Y

Reproductive sciences (Thousand Oaks, Calif.) 1933719119828095 Feb 2019 [Refereed]

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis.

Sun H, Fukuda S, Hirata T, Arakawa T, Ma S, Neriishi K, Wang Y, Takeuchi A, Saeki A, Harada M, Hirota Y, Matsumoto T, Koga K, Wada-Hiraike O, Kurihara M, Fujii T, Osuga Y

Reproductive sciences (Thousand Oaks, Calif.) 1933719119831782 Feb 2019 [Refereed]

ER Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.

Azhary JMK, Harada M, Takahashi N, Nose E, Kunitomi C, Koike H, Hirata T, Hirota Y, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

Endocrinology Nov 2018 [Refereed]

Long-term dienogest administration in patients with symptomatic adenomyosis.

Neriishi K, Hirata T, Fukuda S, Izumi G, Nakazawa A, Yamamoto N, Harada M, Hirota Y, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research 44(8) 1439-1444 Aug 2018 [Refereed]

Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality.

Haraguchi H, Hirota Y, Saito-Fujita T, Tanaka T, Shimizu-Hirota R, Harada M, Akaeda S, Hiraoka T, Matsuo M, Matsumoto L, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

FASEB journal : official publication of the Federation of American Societies for Experimental Biology fj201801401R Sep 2018 [Refereed]

The efficacy of non-assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s.

Isono W, Wada-Hiraike O, Akino N, Terao H, Harada M, Hirata T, Hirota Y, Koga K, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research 45(2) 368-375 Oct 2018 [Refereed]

Factors associated with successful pregnancy in women of late reproductive age with uterine fibroids who undergo embryo cryopreservation before surgery.

Takahashi N, Harada M, Tanabe R, Takayanagi A, Izumi G, Oi N, Hirata T, Wada-Hiraike O, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research 44(10) 1956-1962 Jul 2018 [Refereed]

Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis.

Miyashita M, Koga K, Takeuchi A, Makabe T, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Yoshino O, Fujii T, Osuga Y

Reproductive sciences (Thousand Oaks, Calif.) 1933719118806395 Oct 2018 [Refereed]

Activation of Nrf2 might reduce oxidative stress in human granulosa cells.

Akino N, Wada-Hiraike O, Terao H, Honjoh H, Isono W, Fu H, Hirano M, Miyamoto Y, Tanikawa M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Kawana K, Fujii T, Osuga Y

Molecular and cellular endocrinology 470 96-104 Jul 2018 [Refereed]

Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis.

Fukuda S, Hirata T, Neriishi K, Nakazawa A, Takamura M, Izumi G, Harada M, Hirota Y, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

European journal of obstetrics, gynecology, and reproductive biology 225 118-123 Jun 2018 [Refereed]

Management of the female athlete triad.

Nose-Ogura S, Harada M, Hiraike O, Osuga Y, Fujii T

The journal of obstetrics and gynaecology research 44(6) 1007-1014 Jun 2018 [Refereed]

Development of endometrioma after cervical conization.

Takahashi N, Koga K, Arakawa I, Harada M, Oda K, Kawana K, Fujii T, Osuga Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 34(4) 341-344 Apr 2018 [Refereed]

Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens.

Nose-Ogura S, Yoshino O, Dohi M, Kigawa M, Harada M, Kawahara T, Osuga Y, Saito S

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine Mar 2018 [Refereed]

Fertility preservation for female cancer patients.

Harada M, Osuga Y

International journal of clinical oncology Mar 2018 [Refereed]

Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis.

Takahashi N, Harada M, Hirota Y, Nose E, Azhary JM, Koike H, Kunitomi C, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Chang RJ, Shimasaki S, Fujii T, Osuga Y

Scientific reports 7(1) 10824 Sep 2017 [Refereed]

A survey of public attitudes towards third-party reproduction in Japan in 2014.

Yamamoto N, Hirata T, Izumi G, Nakazawa A, Fukuda S, Neriishi K, Arakawa T, Takamura M, Harada M, Hirota Y, Koga K, Wada-Hiraike O, Fujii T, Irahara M, Osuga Y

PloS one 13(10) e0198499 2018 [Refereed]

PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-β and TNF-α in mononuclear cells by insulin-sensitizing drugs.

Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S

American journal of reproductive immunology (New York, N.Y. : 1989) 78(1) Jul 2017 [Refereed]

Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility.

Izumi G, Koga K, Takamura M, Bo W, Nagai M, Miyashita M, Harada M, Hirata T, Hirota Y, Yoshino O, Fujii T, Osuga Y

Journal of immunology (Baltimore, Md. : 1950) 198(11) 4277-4284 Jun 2017 [Refereed]

Oral contraceptive therapy reduces serum relaxin-2 in elite female athletes.

Nose-Ogura S, Yoshino O, Yamada-Nomoto K, Nakamura M, Harada M, Dohi M, Okuwaki T, Osuga Y, Kawahara T, Saito S

The journal of obstetrics and gynaecology research 43(3) 530-535 Mar 2017 [Refereed]

Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells.

Makabe T, Koga K, Miyashita M, Takeuchi A, Sue F, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

Journal of reproductive immunology 119 44-48 Feb 2017 [Refereed]

Preoperative assessment of factors associated with difficulty in performing total laparoscopic hysterectomy.

Saito A, Hirata T, Koga K, Takamura M, Fukuda S, Neriishi K, Pastorfide G, Harada M, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research 43(2) 320-329 Feb 2017 [Refereed]

The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis.

Hirano M, Wada-Hiraike O, Fu H, Akino N, Isono W, Sakurabashi A, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Nishi Y, Yanase T, Harada M, Oishi H, Yano T, Koga K, Oda K, Kawana K, Fujii T, Osuga Y

Reproductive sciences (Thousand Oaks, Calif.) 24(1) 133-141 Jan 2017 [Refereed]

Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis.

Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y

Fertility and sterility 107(1) 167-173.e2 Jan 2017 [Refereed]

A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women.

Takahashi N, Harada M, Hirota Y, Zhao L, Azhary JM, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

Endocrinology 158(1) 84-97 Jan 2017 [Refereed]

Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis.

Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y

European journal of obstetrics, gynecology, and reproductive biology 207 157-161 Dec 2016 [Refereed]

Development of ovarian cancer after excision of endometrioma.

Haraguchi H, Koga K, Takamura M, Makabe T, Sue F, Miyashita M, Urata Y, Izumi G, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Oda K, Kawana K, Fujii T, Osuga Y

Fertility and sterility 106(6) 1432-1437.e2 Nov 2016 [Refereed]

Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study.

Fujii T, Wada-Hiraike O, Nagamatsu T, Harada M, Hirata T, Koga K, Fujii T, Osuga Y

Reproductive biology and endocrinology : RB&E 14(1) 73 Nov 2016 [Refereed]

Where are oncofertility and fertility preservation treatments heading in 2016?

Harada M, Osuga Y

Future oncology (London, England) 12(20) 2313-2321 Oct 2016 [Refereed]

Usefulness of T2 star-weighted imaging in ovarian cysts and tumors.

Takahashi N, Yoshino O, Maeda E, Naganawa S, Harada M, Koga K, Hiraike O, Nakamura M, Tabuchi T, Hori M, Saito S, Fujii T, Osuga Y

The journal of obstetrics and gynaecology research 42(10) 1336-1342 Oct 2016 [Refereed]

Neutrophil depletion reduces endometriotic lesion formation in mice.

Takamura M, Koga K, Izumi G, Urata Y, Nagai M, Hasegawa A, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

American journal of reproductive immunology (New York, N.Y. : 1989) 76(3) 193-198 Sep 2016 [Refereed]

A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome.

Takahashi N, Harada M, Hirota Y, Zhao L, Yoshino O, Urata Y, Izumi G, Takamura M, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

Molecular and cellular endocrinology 428 161-169 Jun 2016 [Refereed]

Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis.

Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

The Journal of clinical endocrinology and metabolism 101(6) 2371-2379 Jun 2016 [Refereed]

Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.

Sato M, Harada M, Oishi H, Wada-Hiraike O, Hirata T, Nagasaka K, Koga K, Fujii T, Osuga Y

Journal of lower genital tract disease 20(2) e11-3 Apr 2016 [Refereed]

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells.

Taguchi A, Koga K, Kawana K, Makabe T, Sue F, Miyashita M, Yoshida M, Urata Y, Izumi G, Tkamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y

American journal of reproductive immunology (New York, N.Y. : 1989) 75(4) 486-492 Apr 2016 [Refereed]

The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI.

Takahashi N, Yoshino O, Hiraike O, Maeda E, Nakamura M, Hori M, Harada M, Koga K, Saito S, Fujii T, Osuga Y

SpringerPlus 5(1) 1907 2016 [Refereed]

Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis.

Takamura M, Koga K, Izumi G, Hirata T, Harada M, Hirota Y, Hiraike O, Fujii T, Osuga Y

American journal of reproductive immunology (New York, N.Y. : 1989) 74(6) 480-486 Dec 2015 [Refereed]

Elective single-embryo transfer improves cumulative pregnancy outcome in young patients but not in women of advanced reproductive age.

Fujimoto A, Morishima K, Harada M, Hirata T, Osuga Y, Fujii T

Journal of assisted reproduction and genetics 32(12) 1773-1779 Dec 2015 [Refereed]

Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation.

Harada M, Nose E, Takahashi N, Hirota Y, Hirata T, Yoshino O, Koga K, Fujii T, Osuga Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 31(10) 783-787 Oct 2015 [Refereed]

Four Cases of Postoperative Pneumothorax Among 2814 Consecutive Laparoscopic Gynecologic Surgeries: A Possible Correlation Between Postoperative Pneumothorax and Endometriosis.

Hirata T, Nakazawa A, Fukuda S, Hirota Y, Izumi G, Takamura M, Harada M, Koga K, Wada-Hiraike O, Fujii T, Osuga Y

Journal of minimally invasive gynecology 22(6) 980-984 Sep 2015 [Refereed]

Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.

Miyashita M, Koga K, Izumi G, Makabe T, Hasegawa A, Hirota Y, Hirata T, Harada M, Fujii T, Osuga Y

Fertility and sterility 104(1) 217-24.e2 Jul 2015 [Refereed]

Cyclic stretch augments production of neutrophil chemokines, matrix metalloproteinases, and activin a in human endometrial stromal cells.

Izumi G, Koga K, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Ogawa K, Inoue S, Fujii T, Osuga Y

American journal of reproductive immunology (New York, N.Y. : 1989) 73(6) 501-506 Jun 2015 [Refereed]

Laparoscopic excision of ovarian endometrioma does not exert a qualitative effect on ovarian function: insights from in vitro fertilization and single embryo transfer cycles.

Harada M, Takahashi N, Hirata T, Koga K, Fujii T, Osuga Y

Journal of assisted reproduction and genetics 32(5) 685-689 May 2015 [Refereed]

IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells.

Urata Y, Koga K, Hirota Y, Akiyama I, Izumi G, Takamura M, Nagai M, Harada M, Hirata T, Yoshino O, Kawana K, Fujii T, Osuga Y

American journal of reproductive immunology (New York, N.Y. : 1989) 72(5) 496-503 Nov 2014 [Refereed]

Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study.

Hirata T, Izumi G, Takamura M, Saito A, Nakazawa A, Harada M, Hirota Y, Koga K, Fujii T, Osuga Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 30(10) 726-729 Oct 2014 [Refereed]

Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis.

Miyashita M, Koga K, Takamura M, Izumi G, Nagai M, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 30(9) 644-648 Sep 2014 [Refereed]

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer.

Fujimoto A, Ichinose M, Harada M, Hirata T, Osuga Y, Fujii T

Journal of assisted reproduction and genetics 31(9) 1189-1194 Sep 2014 [Refereed]

The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.

Akiyama I, Yoshino O, Osuga Y, Shi J, Takamura M, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S

Reproductive sciences (Thousand Oaks, Calif.) 21(6) 772-777 Jun 2014 [Refereed]

Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells.

Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S

Reproductive sciences (Thousand Oaks, Calif.) 21(4) 477-482 Apr 2014 [Refereed]

Individualized management of umbilical endometriosis: a report of seven cases.

Saito A, Koga K, Osuga Y, Harada M, Takemura Y, Yoshimura K, Yano T, Kozuma S

The journal of obstetrics and gynaecology research 40(1) 40-45 Jan 2014 [Refereed]

Predictive factors for recurrence of ovarian mature cystic teratomas after surgical excision.

Harada M, Osuga Y, Fujimoto A, Fujimoto A, Fujii T, Yano T, Kozuma S

European journal of obstetrics, gynecology, and reproductive biology 171(2) 325-328 Dec 2013 [Refereed]

Follistatin is induced by IL-1β and TNF-α in stromal cells from endometrioma.

Akiyama I, Yoshino O, Osuga Y, Izumi G, Urata Y, Hirota Y, Hirata T, Harada M, Koga K, Ogawa K, Kozuma S

Reproductive sciences (Thousand Oaks, Calif.) 20(6) 675-679 Jun 2013 [Refereed]

The significance of serum anti-Müllerian hormone (AMH) levels in patients over age 40 in first IVF treatment.

Tokura Y, Yoshino O, Ogura-Nose S, Motoyama H, Harada M, Osuga Y, Shimizu Y, Ohara M, Yorimitsu T, Nishii O, Kozuma S, Kawamura T

Journal of assisted reproduction and genetics 30(6) 821-825 Jun 2013 [Refereed]

Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinases-1 (MMP-1) from human decidual cells, and the production was reduced by progesterone.

Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Inoue S, Fujii T, Kozuma S

American journal of reproductive immunology (New York, N.Y. : 1989) 69(5) 454-462 May 2013 [Refereed]

Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells.

Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S

The Journal of clinical endocrinology and metabolism 98(4) 1583-1590 Apr 2013 [Refereed]

Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells.

Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Fujii T, Kozuma S

American journal of reproductive immunology (New York, N.Y. : 1989) 69(3) 240-247 Mar 2013 [Refereed]

The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary.

Akiyama I, Yoshino O, Osuga Y, Shi J, Hirota Y, Hirata T, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y

American journal of reproductive immunology (New York, N.Y. : 1989) 68(6) 491-498 Dec 2012 [Refereed]

Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells.

Takamura M, Osuga Y, Izumi G, Yoshino O, Koga K, Saito A, Hirata T, Hirota Y, Harada M, Hasegawa A, Taketani Y

Fertility and sterility 98(5) 1218-24.e1 Nov 2012 [Refereed]

Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia.

Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y

Fertility and sterility 98(4) 917-921 Oct 2012 [Refereed]

Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis.

Urata Y, Osuga Y, Izumi G, Takamura M, Koga K, Nagai M, Harada M, Hirata T, Hirota Y, Yoshino O, Taketani Y

Human reproduction (Oxford, England) 27(10) 3028-3035 Oct 2012 [Refereed]

Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss.

Tsutsumi R, Fujimoto A, Osuga Y, Harada M, Takemura Y, Koizumi M, Yano T, Taketani Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 28(6) 460-462 Jun 2012 [Refereed]

Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.

Shi J, Yoshino O, Osuga Y, Akiyama I, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y

Fertility and sterility 97(4) 979-983 Apr 2012 [Refereed]

Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts.

Wang B, Koga K, Osuga Y, Cardenas I, Izumi G, Takamura M, Hirata T, Yoshino O, Hirota Y, Harada M, Mor G, Taketani Y

Endocrinology 152(12) 4984-4992 Dec 2011 [Refereed]

Dienogest, a new conservative strategy for extragenital endometriosis: a pilot study.

Harada M, Osuga Y, Izumi G, Takamura M, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 27(9) 717-720 Sep 2011 [Refereed]

High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia.

Wang B, Koga K, Osuga Y, Hirata T, Saito A, Yoshino O, Hirota Y, Harada M, Takemura Y, Fujii T, Taketani Y

American journal of reproductive immunology (New York, N.Y. : 1989) 66(2) 143-148 Aug 2011 [Refereed]

TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6.

Saito A, Osuga Y, Yoshino O, Takamura M, Hirata T, Hirota Y, Koga K, Harada M, Takemura Y, Yano T, Taketani Y

Human reproduction (Oxford, England) 26(7) 1892-1898 Jul 2011 [Refereed]

Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis.

Hirata T, Osuga Y, Takamura M, Saito A, Hasegawa A, Koga K, Yoshino O, Hirota Y, Harada M, Taketani Y

Fertility and sterility 96(1) 113-117 Jul 2011 [Refereed]

Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma.

Yoshino O, Izumi G, Shi J, Osuga Y, Hirota Y, Hirata T, Harada M, Nishii O, Koga K, Taketani Y

Fertility and sterility 96(1) 118-121 Jul 2011 [Refereed]

The function of bone morphogenetic proteins in the human ovary.

Yoshino O, Shi J, Osuga Y, Harada M, Nishii O, Yano T, Taketani Y

Reproductive medicine and biology 10(1) 1-7 Mar 2011 [Refereed]

Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells.

Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, Yoshino O, Harada M, Takemura Y, Yano T, Taketani Y

Endocrinology 151(11) 5468-5476 Nov 2010 [Refereed]

Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells.

Fisseha S, Towns R, Harada M, Peegel H, Menon KM

Endocrine 37(1) 187-193 Feb 2010 [Refereed]

Case of chronic ectopic pregnancy diagnosed in which the complete shape of the fetus was visible by ultrasonography.

Harada M, Hiroi H, Fujiwara T, Fujimoto A, Kikuchi A, Osuga Y, Momoeda M, Kugu K, Yano T, Taketani Y

The journal of obstetrics and gynaecology research 36(2) 462-465 Apr 2010 [Refereed]

Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism.

Menon KM, Menon B, Wang L, Gulappa T, Harada M

Molecular and cellular endocrinology 329(1-2) 26-32 Nov 2010 [Refereed]

Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells.

Kodama A, Yoshino O, Osuga Y, Harada M, Hasegawa A, Hamasaki K, Takamura M, Koga K, Hirota Y, Hirata T, Takemura Y, Yano T, Taketani Y

Human reproduction (Oxford, England) 25(3) 751-756 Mar 2010 [Refereed]

Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary.

Harada M, Peegel H, Menon KM

Molecular and cellular endocrinology 328(1-2) 28-33 Oct 2010 [Refereed]

Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells.

Hasegawa A, Osuga Y, Hirota Y, Hamasaki K, Kodama A, Harada M, Tajima T, Takemura Y, Hirata T, Yoshino O, Koga K, Yano T, Taketani Y

Human reproduction (Oxford, England) 24(2) 408-414 Feb 2009 [Refereed]

Interleukin (IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8.

Hirota Y, Osuga Y, Hasegawa A, Kodama A, Tajima T, Hamasaki K, Koga K, Yoshino O, Hirata T, Harada M, Takemura Y, Yano T, Tsutsumi O, Taketani Y

Endocrinology 150(1) 350-356 Jan 2009 [Refereed]

Interleukin-4 stimulates proliferation of endometriotic stromal cells.

OuYang Z, Hirota Y, Osuga Y, Hamasaki K, Hasegawa A, Tajima T, Hirata T, Koga K, Yoshino O, Harada M, Takemura Y, Nose E, Yano T, Taketani Y

The American journal of pathology 173(2) 463-469 Aug 2008 [Refereed]

Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells.

Hirata T, Osuga Y, Hamasaki K, Yoshino O, Ito M, Hasegawa A, Takemura Y, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Saito S, Yano T, Taketani Y

Endocrinology 149(3) 1260-1267 Mar 2008 [Refereed]

Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.

Takemura Y, Osuga Y, Yoshino O, Hasegawa A, Hirata T, Hirota Y, Nose E, Morimoto C, Harada M, Koga K, Tajima T, Yano T, Taketani Y

The Journal of clinical endocrinology and metabolism 92(8) 3213-3218 Aug 2007 [Refereed]

Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle.

Hirata T, Osuga Y, Hamasaki K, Hirota Y, Nose E, Morimoto C, Harada M, Takemura Y, Koga K, Yoshino O, Tajima T, Hasegawa A, Yano T, Taketani Y

Journal of reproductive immunology 74(1-2) 53-60 Jun 2007 [Refereed]

Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia.

Takemura Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y

Journal of reproductive immunology 73(1) 60-65 Feb 2007 [Refereed]

The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium.

Hirota Y, Osuga Y, Koga K, Yoshino O, Hirata T, Morimoto C, Harada M, Takemura Y, Nose E, Yano T, Tsutsumi O, Taketani Y

Journal of immunology (Baltimore, Md. : 1950) 177(12) 8813-8821 Dec 2006 [Refereed]

Expression of adiponectin receptors and its possible implication in the human endometrium.

Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, Morimoto C, Hirota Y, Yoshino O, Koga K, Yano T, Kadowaki T, Taketani Y

Endocrinology 147(7) 3203-3210 Jul 2006 [Refereed]

Mechanical stretch upregulates IGFBP-1 secretion from decidualized endometrial stromal cells.

Harada M, Osuga Y, Takemura Y, Yoshino O, Koga K, Hirota Y, Hirata T, Morimoto C, Yano T, Taketani Y

American journal of physiology. Endocrinology and metabolism 290(2) E268-72 Feb 2006 [Refereed]

Serum adiponectin concentrations are decreased in women with endometriosis.

Takemura Y, Osuga Y, Harada M, Hirata T, Koga K, Morimoto C, Hirota Y, Yoshino O, Yano T, Taketani Y

Human reproduction (Oxford, England) 20(12) 3510-3513 Dec 2005 [Refereed]

Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells.

Hirota Y, Osuga Y, Hirata T, Harada M, Morimoto C, Yoshino O, Koga K, Yano T, Tsutsumi O, Taketani Y

Human reproduction (Oxford, England) 20(12) 3547-3553 Dec 2005 [Refereed]

GnRH II as a possible cytostatic regulator in the development of endometriosis.

Morimoto C, Osuga Y, Yano T, Takemura Y, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kugu K, Taketani Y

Human reproduction (Oxford, England) 20(11) 3212-3218 Nov 2005 [Refereed]

Sciatic endometriosis diagnosed by computerized tomography-guided biopsy and CD10 immunohistochemical staining.

Koga K, Osuga Y, Harada M, Hirota Y, Yamada H, Akahane M, Kugu K, Taketani Y

Fertility and sterility 84(5) 1508 Nov 2005 [Refereed]

Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis.

Takemura Y, Osuga Y, Harada M, Hirata T, Koga K, Yoshino O, Hirota Y, Morimoto C, Yano T, Taketani Y

American journal of reproductive immunology (New York, N.Y. : 1989) 54(4) 217-221 Oct 2005 [Refereed]

Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein.

Hirata T, Osuga Y, Yoshino O, Hirota Y, Harada M, Takemura Y, Morimoto C, Koga K, Yano T, Tsutsumi O, Taketani Y

Human reproduction (Oxford, England) 20(8) 2092-2096 Aug 2005 [Refereed]

Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis.

Hirota Y, Osuga Y, Hirata T, Yoshino O, Koga K, Harada M, Morimoto C, Nose E, Yano T, Tsutsumi O, Taketani Y

The Journal of clinical endocrinology and metabolism 90(6) 3673-3679 Jun 2005 [Refereed]

Possible implication of midkine in the development of endometriosis.

Hirota Y, Osuga Y, Koga K, Yoshino O, Hirata T, Harada M, Morimoto C, Yano T, Tsutsumi O, Sakuma S, Muramatsu T, Taketani Y

Human reproduction (Oxford, England) 20(4) 1084-1089 Apr 2005 [Refereed]

Evidence for the presence of protease-activated receptor 2 and its possible implication in remodeling of human endometrium.

Hirota Y, Osuga Y, Hirata T, Koga K, Yoshino O, Harada M, Morimoto C, Nose E, Yano T, Tsutsumi O, Taketani Y

The Journal of clinical endocrinology and metabolism 90(3) 1662-1669 Mar 2005 [Refereed]

Misc

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広基性に単角子宮と連続している非交通性副角子宮に対して,腹腔鏡下副角子宮切除術を行った1例

泉玄太郎, 森嶋かほる, 山本直子, 原田美由紀, 平田哲也, 甲賀かをり, 平池修, 大須賀穣, 藤井知行

臨床婦人科産科 72(8) 823-826 Aug 2018

＜文献概要＞非交通性副角子宮を伴う単角子宮は,副角切除術の適応になる.低侵襲性や整容性から腹腔鏡下手術も選択肢になるが,その手術難易度は副角子宮と単角子宮の位置関係によって大きく変わる.われわれは,単角子宮と広基性に連続している副角子宮を腹腔鏡下に切除したので報告する.術前に造影CTによる血管走行の評価を行い,子宮頸部への血流を極力残すことに留意した.また,子宮鏡を術中に使用して,子宮筋層を透見することで,切除範囲の確認を行った.そして,術前には子宮筋腫摘出術を想定した準備を行った.術中術...

当院における妊孕性温存療法の現状

森嶋かほる, 原田美由紀, 大井なぎさ, 賀来明音, 眞田裕子, 宮下真理子, 平野茉来, 原口広史, 秋山育美, 金谷真由子, 能瀬さやか, 高村将司, 平田哲也, 廣田泰, 甲賀かをり, 平池修, 大須賀穣, 藤井知行

日本生殖医学会雑誌 63(3) 300-300 Aug 2018

腹腔鏡下子宮筋腫核出後にparasitic myomaを認めた一例

福田晋也, 高村将司, 平池修, 樋野貴宏, 森嶋かほる, 原田美由紀, 平田哲也, 廣田泰, 甲賀かをり, 大須賀穣, 藤井知行

日本産科婦人科内視鏡学会雑誌 34(Suppl.I) 176-176 Aug 2018

子宮筋腫合併高齢不妊患者に対するEmbryo cryopreservation before surgery(ECBS)の有効性についての検討

高橋望, 原田美由紀, 田邉良介, 賀来明音, 大井なぎさ, 泉玄太郎, 平田哲也, 大須賀穣, 藤井知行

日本生殖医学会雑誌 63(3) 322-322 Aug 2018

当院で悪性腫瘍を専門にする医師の日本産科婦人科内視鏡学会技術認定取得の現状と課題

大木慎也, 宮本雄一郎, 谷川道洋, 曾根献文, 鶴賀哲史, 原田美由紀, 松本陽子, 甲賀かをり, 平池修, 織田克利, 大須賀穣, 藤井知行

日本産科婦人科内視鏡学会雑誌 34(Suppl.I) 188-188 Aug 2018

Conference Activities & Talks

Plain Text

Accumulation of advanced glycation end products in follicles is associated with poor oocyte quality: inducing inflammation in granulosa cells via activation of unfolded protein response

Miyuki Harada

Jun 2019

ER Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS

Jerilee MK Azhary, Miyuki Harada et al.

101st The Endocrine Societys' Annual Meeting and Expo (ENDO) Mar 2019

Fertility Preservation for Cancer Patients in Japan ―Present and Future― [Invited]

Miyuki Harada

International Symposium 'Ferility Preservation for Cancer Patients in Asia' Dec 2018

Emerging Roles of Endoplasmic Reticulum Stress in the Ovary [Invited]

Miyuki Harada

Jerry Menon Career Celebration Symposium Apr 2018

A National Survey of Cryopreservation of Embryos, Oocytes, and Ovarian Tissue for Cancer Patients

Miyuki Harada, et al

69th Annual Congress of the Japan Society of Obstetrics and Gynecology Apr 2018

Aging and Reproductive Health －Perspectives for Ovarian Anti-Aging― [Invited]

Miyuki Harada

2018 Beijing Annual Meeting of Obstetrics and Gynecology Mar 2018

Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis

Nozomi Takahashi, Miyuki Harada, et al.

100th The Endocrine Society' Annual Meeting & EXPO (ENDO) Mar 2018

Keynote Address 'Fertility Preservation in Endometriosis' [Invited]

Miyuki Harada

2nd Annual Conference of Asian Society for Fertility Preservation Sep 2018

Association Memberships

Asia Pacific Initiative on Reproduction(1) , European Society of Human Reproduction and Embryology(5) , Endocrine Society(45) , JAPAN SOCIETY FOR IMMUNOLOGY OF REPRODUCTION(23) , JAPAN SOCIETY OF FERTILIZATION AND IMPLANTATION(50) , JAPAN SOCIETY OF CLINICAL ONCOLOGY(534) , JAPAN SOCIETY FOR OVA RESEARCH(42) , THE JAPAN SOCIETY FOR MENOPAUSE AND WOMEN'S HEALTH(60) , JAPAN SOCIETY OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY AND MINIMALLY INVASIVE THERAPY(70) , JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE(126) , JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY(202)