論文

査読有り
2015年9月1日

Retrospective study of laryngeal preservation treatment for hypopharyngeal carcinoma with transoral resection or induction chemotherapy

Journal of Otolaryngology of Japan
  • Takahiro Asakage
  • ,
  • Mizuo Ando
  • ,
  • Masafumi Yoshida
  • ,
  • Yuki Saito
  • ,
  • Go Omura
  • ,
  • Tatsuya Yamasoba

118
9
開始ページ
1118
終了ページ
1123
記述言語
日本語
掲載種別
研究論文(学術雑誌)
DOI
10.3950/jibiinkoka.118.1118
出版者・発行元
Oto-Rhino-Laryngological Society of Japan Inc.

We have performed transoral surgical resection for patients with T1/T2 hypopharyngeal cancer and induction chemotherapy with docetaxel for patients with T2/T3 disease. The patients were analyzed in order to determine the current situation of larynx preservation in patients with hypopharyngeal cancer. The data of a total of 83 patients with hypopharyngeal cancer were analyzed retrospectively. The primary subsites were: pyriform sinus (PS) in 61 patients, posterior wall (PW) in 13 patients, and postcricoid (PC) in 9 patients. The number of patients classified as having T1, T2, T3 and T4 disease were 14, 29, 23 and 17, respectively. The main therapies employed in the patients were as follows: transoral surgical resection plus radiation therapy for Tl disease, radiation therapy, induction chemotherapy, and partial resection for T2 disease, induction chemotherapy, radiation therapy, and pharyngo-laryngoesophagectomy for T3 disease, and pharyngo-laryngoesophagectomy plus induction chemotherapy for T4 disease. The 5-year larynx preservation rates in the patients with T1, T2, T3 and T4 disease were 100%, 73%, 39% and 35%, respectively. Our method was able to improve the larynx preservation rate without having any adverse effect on the survival rate. However, the strength of treatment for T 3 disease needs to be improved, because a large number of recurrences and deaths due to the primary disease were encountered in this patient group.

リンク情報
DOI
https://doi.org/10.3950/jibiinkoka.118.1118
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26615662
ID情報
  • DOI : 10.3950/jibiinkoka.118.1118
  • ISSN : 0030-6622
  • PubMed ID : 26615662
  • SCOPUS ID : 84946039355

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