論文

査読有り
2017年6月

Age-dependent atypicalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD

NEUROSCIENCE RESEARCH
  • Yuko Okamoto
  • ,
  • Hirotaka Kosaka
  • ,
  • Ryo Kitada
  • ,
  • Ayumi Seki
  • ,
  • Hiroki C. Tanabe
  • ,
  • Masamichi J. Hayashi
  • ,
  • Takanori Kochiyama
  • ,
  • Daisuke N. Saito
  • ,
  • Hisakazu T. Yanaka
  • ,
  • Toshio Munesue
  • ,
  • Makoto Ishitobi
  • ,
  • Masao Omori
  • ,
  • Yuji Wada
  • ,
  • Hidehiko Okazawa
  • ,
  • Tatsuya Koeda
  • ,
  • Norihiro Sadato

119
開始ページ
38
終了ページ
52
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neures.2017.02.001
出版者・発行元
ELSEVIER IRELAND LTD

Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.neures.2017.02.001
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404696300005&DestApp=WOS_CPL
URL
http://www.sciencedirect.com/science/article/pii/S0168010216302437