論文

査読有り 国際誌
2020年

Controlling the degradation of cellulose scaffolds with Malaprade oxidation for tissue engineering

Journal of Materials Chemistry B
  • Wichchulada Chimpibul
  • ,
  • Tadashi Nakaji-Hirabayashi
  • ,
  • Xida Yuan
  • ,
  • Kazuaki Matsumura

8
35
開始ページ
7904
終了ページ
7913
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/D0TB01015D
出版者・発行元
Royal Society of Chemistry ({RSC})

This study was conducted to develop biodegradable cellulose scaffolds by oxidising porous cellulose sponges for tissue engineering applications. Cellulose powder was dissolved in ionic liquid using a salt leaching method, and porous cellulose scaffolds of various pore sizes were prepared. The scaffolds were oxidised with periodate to introduce aldehyde at a rate controlled by the periodate concentration. Oxidised scaffolds exhibited weight loss in cell culture medium, but not in phosphate buffer. Therefore, we confirmed that Schiff base formation between the aldehyde and amino groups through a Maillard reaction triggered cellulose molecular degradation. The degradation rate was controlled by the oxidation degree, whereas the aldehyde content controlled protein adsorption and cell proliferation. Additionally, in vivo implantation tests revealed that optimising the oxidation ratio not only improved biodegradability but also reduced inflammation. In conclusion, our results suggest that simple oxidised cellulose is useful as a low-toxicity biodegradable scaffold.

リンク情報
DOI
https://doi.org/10.1039/D0TB01015D
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32812617
ID情報
  • DOI : 10.1039/D0TB01015D
  • ORCIDのPut Code : 79049797
  • PubMed ID : 32812617

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